| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
During the mitotic phase of the mammalian cell cycle, DNA is tightly packaged in condensed chromosomes, transcription factors are displaced from DNA, and all genes are silenced. Accordingly, the condensed condition of mitotic chromosomes has been assumed to inhibit all kinds of DNA metabolism. In the present study, DNA repair activity in mitotic cells was investigated. Unexpectedly, it was observed that some modes of DNA repair were functional in mitotic cells, suggesting that the proteins involved in these DNA repair modes could function in condensed mitotic chromosomes.
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