Mechanism of translational repression by uORF of thyroid hormone receptor a mRNA
| Project/Area Number |
21570182
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Molecular biology
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| Research Institution | Hiroshima University |
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Principal Investigator |
YAOITA Yoshio 広島大学, 大学院・理学研究科, 教授 (00166472)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAJIMA Keisuke 広島大学, 大学院・理学研究科, 助教 (60260311)
TAZAWA Ichirou 広島大学, 大学院・理学研究科, 助教 (10304388)
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| Research Collaborator |
OKADA Morihiro 広島大学, 大学院・理学研究科, 博士課程
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 翻訳 / 翻訳抑制 / 甲状腺ホルモンα / 5'-UTR / uORF / 甲状腺ホルモン受容体 / 5'-非翻訳領域(5'-UTR) / ツメガエル / 変態 / 両生類 |
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| Research Abstract |
During amphibian metamorphosis, thyroid hormone induces a series of dynamic morphological changes. We showed that the 5'-untranslated region(5'-UTR) reduces the translation of the thyroid hormone receptor(TR)αmRNA to one-twentieth. Five elements in TRα5'-UTR, which are composed of 15 to 24 nucleotides, possess translational repressive activity, and inhibit the translation of the downstream open reading frame in the 5'-UTRs of other mRNAs. There is a novel translational repressive sequence similar to the Sp1-binding site among elements.
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] NBRP databases : databases of biological resources in Japan2010
Author(s)
Yukiko Yamazaki, Ryo Akashi, Yutaka Banno, Takashi Endo, Hiroshi Ezura, KaoruFukami-Kobayashi, Kazuo Inaba, Tadashi Isa, Katsuhiko Kamei, Fumie Kasai, MasatomoKobayashi, Nori Kurata, Makoto Kusaba, TetsuroMatuzawa, Shohei Mitani, Taro Nakamura, YukioNakamura, Norio Nakatsuji, Kiyoshi Naruse, Hironori Niki, Eiji Nitasaka, Yuichi Obata, Hitoshi Okamoto, Moriya Okuma, Kazuhiro Sato, Tadao Serikawa, Toshihiko Shiroishi, HideakiSugawara, Hideko Urushibara, MasatoshiYamamoto, Yoshio Yaoita, Atsushi Yoshiki, and Yuji Kohara
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Journal Title
Nucleic Acids Research
Volume: 38
NAID
Related Report
Peer Reviewed
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