Functional analysis of cis-and trans-acting factors to govern chromatin dynamisms in transcriptional regulation
| Project/Area Number |
21570185
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Molecular biology
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| Research Institution | Meisei University |
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Principal Investigator |
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| Research Collaborator |
KURUMIZAKA Hitoshi 早稲田大学, 理工学術院, 教授 (80300870)
MITCHELL Aaron P. 米国カーネーギーメロン大学, 教授
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 遺伝子 / 発現制御 / ゲノム / クロマチン / ヌクレオソーム / 転写制御 / DNA構造 / ヒストン / 出芽酵母 / 酵母 |
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| Research Abstract |
Mechanisms of nucleosome positioning and its dynamics are one of the central issues to understand gene expression in eukaryotes. In this study, we identified several DNA repeat sequences acting as cis-elements for nucleosome formation and transcriptional regulation in the yeast cells. Also, we investigated the roles of the chromatin remodeling Isw2 complex, the histone deacetylase Rpd3 and histone H3 variants as trans-acting factors fbr nucleosome positioning as well as transcription.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] 5-bromodeoxyuridine induces transcription of repressed genes with disruption of nucleosome positioning.2010
Author(s)
Miki, K., Shimizu, M., Fujii, M., Takayama, S., Hossain, M.N., Ayusawa, D.
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Journal Title
FEBS Journal
Volume: 277
Pages: 4539-4548
Related Report
Peer Reviewed
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