| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
Mechanisms of nucleosome positioning and its dynamics are one of the central issues to understand gene expression in eukaryotes. In this study, we identified several DNA repeat sequences acting as cis-elements for nucleosome formation and transcriptional regulation in the yeast cells. Also, we investigated the roles of the chromatin remodeling Isw2 complex, the histone deacetylase Rpd3 and histone H3 variants as trans-acting factors fbr nucleosome positioning as well as transcription.
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