• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The analysis of the regulation of PIKK by Tel2 family protein

Research Project

Project/Area Number 21570186
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Molecular biology
Research InstitutionKwansei Gakuin University

Principal Investigator

TANAKA Katsunori  関西学院大学, 理工学部, 教授 (60273926)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
KeywordsDNA複製 / DNA損傷 / チェックポイント / 細胞応答 / PIKKキナーゼ / 複製チェックポイント / 分裂酵母 / 細胞周期 / Tel2 / PIKK / ChIP法
Research Abstract

To understand how Tel2 protein regulates the PIKK family proteins conserved among eukaryotes, we tried to isolate conditionally lethal tel2 mutants of fission yeast and analyzed. We found that Tel1^<ATM>/Rad3^<ATR> or Tor1/Tor2^<TOR> were not destabilized in tel2 mutants defective in Tel1^<ATM>/Rad3^<ATR> or Tor1/Tor2^<TOR> pathway, suggesting that Tel2 is not involved in the stability of PIKKs and has a novel function in the regulation of PIKKs.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (34 results)

All 2012 2011 2010 2009 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (24 results) Remarks (4 results)

  • [Journal Article] Arabidopsis thaliana proliferating cell nuclear antigen has several potential sumoylation sites2012

    • Author(s)
      Katsunori Tanaka, Wojciech Strzalka
    • Journal Title

      Journal of Experimental Botany

      Volume: 63 Issue: 8 Pages: 1-13

    • DOI

      10.1093/jxb/ers002

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Arabidopsis thaliana proliferating cell nuclear antigen has several potential sumoylation sites2010

    • Author(s)
      Strzalka, W., Labecki, P., Bartnicki, F., Aggarwal, C., Rapala-Kozik, M., Tani, C., Tanaka, K., Gabrys, H.
    • Journal Title

      J Exp Bot

      Volume: 63(8) Pages: 2367-2373

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multiple Functions of S-phase Checkpoint Mediator2010

    • Author(s)
      Tanaka, K.
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: 74(12) Pages: 2367-2373

    • NAID

      10027727602

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multiple Functions of S-phase Checkpoint Mediator2010

    • Author(s)
      Tanaka K
    • Journal Title

      Biosci.Biotechnol.Biosci.

      Volume: 74 Pages: 2367-2373

    • NAID

      10027727602

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reconstitution of Arabidopsis thaliana SUMO pathways in E. coli : functional evaluation of SUMO machinery proteins and mapping of SUMOylation sites by mass spectrometry2009

    • Author(s)
      Okada, S., Nagabuchi, M., Takamura, Y., Nakagawa, T., Shinmyozu, K., Nakayama, J., Tanaka, K.
    • Journal Title

      Plant Cell Physiol

      Volume: 50(6) Pages: 1049-1061

    • NAID

      130006993917

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reconstitution of Arabidopsis thaliana SUMO pathways in E.coli : functional evaluation of SUMO machinery proteins and mapping of SUMOylation sites by mass spectrometry.2009

    • Author(s)
      Okada S
    • Journal Title

      Plant Cell Physiol. 50

      Pages: 1049-1061

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 分裂酵母Tel2によるPIKK制御機構の解明2011

    • Author(s)
      田中克典
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜市
    • Year and Date
      2011-12-15
    • Related Report
      2011 Final Research Report
  • [Presentation] Biochemical and Genetical Relation of Fission Yeast MCM-binding Protein Mcb1 and MCM Complex2011

    • Author(s)
      Venny Santosa
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜市
    • Year and Date
      2011-12-15
    • Related Report
      2011 Final Research Report
  • [Presentation] Biochemical and Genetical Relation of Fission Yeast MCM-binding Protein Mcb1 and MCM Complex2011

    • Author(s)
      Venny Santosa
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-12-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 分裂酵母Te12によるPIKK制御機構の解明2011

    • Author(s)
      田中克典
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-12-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Fission yeast MCM-binding protein Mcb1 is biochemically and genetically related to MCM complex2011

    • Author(s)
      田中克典
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都市
    • Year and Date
      2011-09-23
    • Related Report
      2011 Final Research Report
  • [Presentation] Fission yeast MCM-binding protein Mcb1 is biochemically and genetically related to MCM complex2011

    • Author(s)
      田中克典
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都国際会館
    • Year and Date
      2011-09-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] The Loading of the S-phase Checkpoint Mediators on Replication Origins2011

    • Author(s)
      田中克典
    • Organizer
      The 6th International Fission Yeast Meeting
    • Place of Presentation
      Boston、USA
    • Year and Date
      2011-06-28
    • Related Report
      2011 Final Research Report
  • [Presentation] The Loading of S-phase Checkpoint Mediators Rediators on Replication Origins2011

    • Author(s)
      田中克典
    • Organizer
      The 6th International Fission Yeast Meeting
    • Place of Presentation
      ボストン アメリカ
    • Year and Date
      2011-06-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Fission yeast MCM-binding protein Mcb1 is biochemically and genetically related to MCM complex2011

    • Author(s)
      Venny Santosa
    • Organizer
      The 6th International Fission Yeast Meeting
    • Place of Presentation
      Boston、USA
    • Year and Date
      2011-06-26
    • Related Report
      2011 Final Research Report
  • [Presentation] Fission yeast MCM-binding protein Mcb1 is biochemically and genetically related to MCM complex2011

    • Author(s)
      Venny Santosa
    • Organizer
      The 6th International Fission Yeast Meeting
    • Place of Presentation
      ボストン アメリカ
    • Year and Date
      2011-06-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] Characterization of Fission Yeast MCM-Binding Protein2011

    • Author(s)
      Venny Santosa
    • Organizer
      International Symposium on the Physicochemical Field for Genetic Activities
    • Place of Presentation
      淡路市
    • Year and Date
      2011-01-24
    • Related Report
      2011 Final Research Report
  • [Presentation] Characterization of Fission Yeast MCM-Binding Protein2011

    • Author(s)
      Venny Santosa
    • Organizer
      International Symposium on the Physicochemical Field for Genetic Activities
    • Place of Presentation
      淡路夢舞台
    • Year and Date
      2011-01-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 分裂酵母HP1ホモログSwi6のSUMO化修飾の意義の解明2011

    • Author(s)
      田中克典
    • Organizer
      第28回染色体ワークショップ
    • Place of Presentation
      加賀市
    • Year and Date
      2011-01-12
    • Related Report
      2011 Final Research Report
  • [Presentation] 分裂酵母HP1ホモログSwi6のSUMO化修飾の意義の解明2011

    • Author(s)
      田中克典
    • Organizer
      第28回 染色体ワークショップ
    • Place of Presentation
      石川県加賀市
    • Year and Date
      2011-01-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] SUMO化修飾による分裂酵母Swi6の機能制御機構の解明2010

    • Author(s)
      山邊史貴
    • Organizer
      第33回日本分子生物学会年会/第83回日本生化学会大会
    • Place of Presentation
      神戸市
    • Year and Date
      2010-12-09
    • Related Report
      2011 Final Research Report
  • [Presentation] 分裂酵母Mrc1のDNA複製開始複合体への結合様式の解明2010

    • Author(s)
      坂井俊介
    • Organizer
      第33回日本分子生物学会年会/第83回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] SUMO化修飾による分裂酵母Swi6の機能制御機構の解明2010

    • Author(s)
      山邊史貴
    • Organizer
      第33回日本分子生物学会年会/第83回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 分裂酵母Mrc1のDNA複製開始複合体への結合様式の解明2010

    • Author(s)
      坂井俊介
    • Organizer
      第33回日本分子生物学会年会/第83回日本生化学会大会
    • Place of Presentation
      神戸市
    • Year and Date
      2010-12-07
    • Related Report
      2011 Final Research Report
  • [Presentation] 分裂酵母MCM-BPタンパク質の機能解析2010

    • Author(s)
      田中克典
    • Organizer
      第27回染色体ワークショップ
    • Place of Presentation
      三島市
    • Year and Date
      2010-01-21
    • Related Report
      2011 Final Research Report
  • [Presentation] 分裂酵母MCM-BPタンパク質の機能解析2010

    • Author(s)
      田中克典
    • Organizer
      第27回染色体ワークショップ
    • Place of Presentation
      御殿場高原時之栖 三島
    • Year and Date
      2010-01-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] 分裂酵母Mrc1のDNA複製フォークへの結合様式の解明2009

    • Author(s)
      坂井俊介
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜市
    • Year and Date
      2009-12-11
    • Related Report
      2011 Final Research Report
  • [Presentation] 分裂酵母Mrc1のDNA複製フォークへの結合様式の解明2009

    • Author(s)
      坂井俊介
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-12-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] THE MRC1 LOADING ONTO THE REPLICATION FORK IN FISSION YEAST2009

    • Author(s)
      Katsunori Tanaka
    • Organizer
      The 5th International Fission Yeast meeting Pombe2009
    • Place of Presentation
      Tokyo
    • Year and Date
      2009-10-29
    • Related Report
      2011 Final Research Report
  • [Presentation] THE MRC1 LOADING ONTO THE REPLICATION FORK IN FISSION YEAST2009

    • Author(s)
      Katsunori Tanaka
    • Organizer
      The 5th International Fission Yeast meeting Pombe2009
    • Place of Presentation
      国立オリンピック記念青少年総合センター, Tokyo
    • Year and Date
      2009-10-29
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://sci-tech.ksc.kwansei.ac.jp/~tanaka/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://sci-tech.ksc.kwansei.ac.jp/~tanaka/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://sci-tech.ksc.kwansei.ac.jp/~tanaka/

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi