| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
To understand how Tel2 protein regulates the PIKK family proteins conserved among eukaryotes, we tried to isolate conditionally lethal tel2 mutants of fission yeast and analyzed. We found that Tel1^<ATM>/Rad3^<ATR> or Tor1/Tor2^<TOR> were not destabilized in tel2 mutants defective in Tel1^<ATM>/Rad3^<ATR> or Tor1/Tor2^<TOR> pathway, suggesting that Tel2 is not involved in the stability of PIKKs and has a novel function in the regulation of PIKKs.
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