The analysis of the regulation of PIKK by Tel2 family protein
Project/Area Number |
21570186
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Molecular biology
|
Research Institution | Kwansei Gakuin University |
Principal Investigator |
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | DNA複製 / DNA損傷 / チェックポイント / 細胞応答 / PIKKキナーゼ / 複製チェックポイント / 分裂酵母 / 細胞周期 / Tel2 / PIKK / ChIP法 |
Research Abstract |
To understand how Tel2 protein regulates the PIKK family proteins conserved among eukaryotes, we tried to isolate conditionally lethal tel2 mutants of fission yeast and analyzed. We found that Tel1^<ATM>/Rad3^<ATR> or Tor1/Tor2^<TOR> were not destabilized in tel2 mutants defective in Tel1^<ATM>/Rad3^<ATR> or Tor1/Tor2^<TOR> pathway, suggesting that Tel2 is not involved in the stability of PIKKs and has a novel function in the regulation of PIKKs.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Arabidopsis thaliana proliferating cell nuclear antigen has several potential sumoylation sites2010
Author(s)
Strzalka, W., Labecki, P., Bartnicki, F., Aggarwal, C., Rapala-Kozik, M., Tani, C., Tanaka, K., Gabrys, H.
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Journal Title
J Exp Bot
Volume: 63(8)
Pages: 2367-2373
Related Report
Peer Reviewed
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[Journal Article] Reconstitution of Arabidopsis thaliana SUMO pathways in E. coli : functional evaluation of SUMO machinery proteins and mapping of SUMOylation sites by mass spectrometry2009
Author(s)
Okada, S., Nagabuchi, M., Takamura, Y., Nakagawa, T., Shinmyozu, K., Nakayama, J., Tanaka, K.
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Journal Title
Plant Cell Physiol
Volume: 50(6)
Pages: 1049-1061
NAID
Related Report
Peer Reviewed
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