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Biological role of condensin in chromosome condensation

Research Project

Project/Area Number 21570188
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Molecular biology
Research InstitutionNational Institute for Basic Biology

Principal Investigator

JOHZUKA Katsuki  基礎生物学研究所, 多様性生物学研究室, 助教 (40291893)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords染色体構造 / クロマチン / 組換え / 転写 / サイレンシング / 分子生物学 / 遺伝学 / 酵母 / ゲノム動態 / 染色体 / 細胞周期 / 細胞分裂 / 染色体分配 / リボソーム遺伝子 / ゲノムダイナミクス / コンデンシン / 合成致死 / リボソームRNA遺伝子 / 蛋白質複合体
Research Abstract

Chromosome condensation is a basic cellular process that ensure the faithful segregation of chromosomes during cell division. This process is required not only for shrinking the length of chromosome arms, but also for resolving entanglements between sister-chromatids that created during DNA replication. In addition, chromosome condensation plays an important role in maintenance of the stability of repetitive structure in genome such as rDNA repeat. Studies in the past decade have demonstrated that chromosome condensation is mainly achieved by condensin, a multi-subunit protein complex widely conserved from yeast to human. In this study, we showed that condensin contributes for transcriptional-and recombinational-repressions within the rDNA repeat in Saccharomyces cerevisiae.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (26 results)

All 2012 2011 2010 2009 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (20 results) Remarks (5 results)

  • [Journal Article] The cis element and factors required for condensing recruitment to chromosomes2009

    • Author(s)
      Johzuka K., Horiuchi T.
    • Journal Title

      Mol Cell

      Volume: 34 Pages: 26-35

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] コンデンシンによるクロマチン折りたたみ2012

    • Author(s)
      定塚勝樹
    • Organizer
      第29回染色体ワークショップ
    • Place of Presentation
      仙台市秋保温泉
    • Year and Date
      2012-01-27
    • Related Report
      2011 Final Research Report
  • [Presentation] コンデンシンによるクロマチン折りたたみ2012

    • Author(s)
      定塚勝樹
    • Organizer
      第29回染色体ワークショップ
    • Place of Presentation
      岩手県・仙台秋保温泉
    • Year and Date
      2012-01-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Condensin-dependent chromatin folding2011

    • Author(s)
      Johzuka K.
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      横浜市パシフィコ横浜
    • Year and Date
      2011-12-15
    • Related Report
      2011 Final Research Report
  • [Presentation] Condensin-dependent chromatin folding2011

    • Author(s)
      定塚勝樹
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      神奈川県・パシフィコ横浜
    • Year and Date
      2011-12-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] コンデンシンによる染色体凝縮の分子機構2011

    • Author(s)
      定塚勝樹
    • Organizer
      DNA複製組換ワークショップ
    • Place of Presentation
      福岡市サンピア福岡
    • Year and Date
      2011-10-27
    • Related Report
      2011 Final Research Report
  • [Presentation] コンデンシンによる染色体凝縮の分子機構2011

    • Author(s)
      定塚勝樹
    • Organizer
      DNA複製・組換・修復ワークショップ
    • Place of Presentation
      福岡県・サンピア福岡
    • Year and Date
      2011-10-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] コンデンシンによる転写と組換え抑制2010

    • Author(s)
      定塚勝樹
    • Organizer
      BMB2010シンポジウム
    • Place of Presentation
      神戸市神戸国際展示場
    • Year and Date
      2010-12-10
    • Related Report
      2011 Final Research Report
  • [Presentation] コンデンシンによる転写と組換え抑制2010

    • Author(s)
      定塚勝樹
    • Organizer
      BMB2010
    • Place of Presentation
      神戸ポートピアホテル(兵庫県)
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Condensin-Dependent Transcriptional Silencing2010

    • Author(s)
      Masako Itazu, Katsuki Johzuka
    • Organizer
      International 3R symosium 2010
    • Place of Presentation
      富山国際会議場(富山県)
    • Year and Date
      2010-10-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] Condensin-dependent transcriptional silencing2010

    • Author(s)
      Itazu M., Johzuka K.
    • Organizer
      International 3R Symposium
    • Place of Presentation
      富山市富山国際会議場
    • Year and Date
      2010-10-26
    • Related Report
      2011 Final Research Report
  • [Presentation] Association of condensin with chromosome mechanism : and its effect on transcriptional silencing2010

    • Author(s)
      Katsuki Johzuka
    • Organizer
      The 57th NIBB conference "Dynamic Genome"
    • Place of Presentation
      Okazaki Conference Center(愛知県)
    • Year and Date
      2010-10-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Association of condensin with chromosome : mechanism and its effect on transcriptional silencing2010

    • Author(s)
      Johzuka K.
    • Organizer
      57th NIBB Conference
    • Place of Presentation
      岡崎市岡崎カンファレンスセンター
    • Related Report
      2011 Final Research Report
  • [Presentation] Condensin contributes to the transcriptional silencing in the rDNA cluster2009

    • Author(s)
      定塚勝樹、板津昌子
    • Organizer
      日本分子生物学会第32回大会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2009-12-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] コンデンシンによるrDNAリピートでの転写抑制機構2009

    • Author(s)
      板津昌子、定塚勝樹
    • Organizer
      3Rワークショップ2009
    • Place of Presentation
      琵琶湖コンファレンスセンター(滋賀県)
    • Year and Date
      2009-11-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] コンデンシンによる転写サイレンシング2009

    • Author(s)
      定塚勝樹、板津昌子
    • Organizer
      酵母遺伝学フォーラム第41回研究報告会
    • Place of Presentation
      筑波・ノバホール(茨城県)
    • Year and Date
      2009-07-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] コンデンシンによる転写抑制2009

    • Author(s)
      定塚勝樹
    • Organizer
      日本遺伝学会第81回大会
    • Place of Presentation
      信州大学(長野県)
    • Year and Date
      2009-07-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Condensin contributes to the transcriptional silencing in the rDNA cluster2009

    • Author(s)
      Itazu M., Johzuka K.
    • Organizer
      日本分子生物学会
    • Place of Presentation
      横浜市パシフィコ横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] コンデンシンによるrDNAリピートでの転写抑制機構2009

    • Author(s)
      板津昌子、定塚勝樹
    • Organizer
      第20回DNA複製・組換え・修復ワークショップ
    • Place of Presentation
      彦根市琵琶湖コンファレンスセンター
    • Related Report
      2011 Final Research Report
  • [Presentation] コンデンシンによる転写抑制2009

    • Author(s)
      定塚勝樹
    • Organizer
      日本遺伝学会
    • Place of Presentation
      松本市信州大学
    • Related Report
      2011 Final Research Report
  • [Presentation] 出芽酵母セントロメア近傍での転写抑制2009

    • Author(s)
      定塚勝樹、板津昌子、石根直美
    • Organizer
      酵母遺伝学フォーラム
    • Place of Presentation
      筑波市ノバホール
    • Related Report
      2011 Final Research Report
  • [Remarks] (1)ホームページ等

    • URL

      http://www.nibb.ac.jp/sections/evolutionary_biology_and_biodiversity/diversity/AssisProf/johzuka.html

    • Related Report
      2011 Final Research Report
  • [Remarks] (2)報道関連情報(1)「たんぱく質と結合」日経産業新聞2009年4月10日11面

    • Related Report
      2011 Final Research Report
  • [Remarks] (2)「結合メカニズム解明」日刊工業新聞2009年4月16日23面

    • Related Report
      2011 Final Research Report
  • [Remarks] (3)「染色体凝縮の謎にメス」科学新聞2009年4月24日4面

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.nibb.ac.jp/sections/evolutionary_biology_and_biodiversity/diversity/AssisProf/johzuka.html

    • Related Report
      2011 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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