Functional elucidation of IRBIT, a master regulator in the central nervous system
| Project/Area Number |
21570190
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Molecular biology
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| Research Institution | Showa Pharmaceutical University (2011)
The Institute of Physical and Chemical Research (2009-2010) |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | IRBIT / 多重リン酸化領域 / 細胞外環境応答 / ストレス反応 / 多重リン酸化 / 細胞外環境センサー / IP3レセプター / マスター調節因子 |
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| Research Abstract |
IRBIT is highly expressed in the glial processes facing and/or ensheathing synaptic clefts. IRBIT interacts with both IP3 receptor and NBC1 in its phosphorylation dependent manner, and modulates their functions. The phosphorylated residues on IRBIT which binds to IP3R with high affinity were revealed to differ from those of IRBIT which binds to NBC1.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Inositol 1, 4, 5-triphosphate receptor-binding protein released with Inositol 1, 4, 5-triphosphate(IRBIT), associates with components of the mRNA 3' processing machinery in a phosphorylation-dependent manner and inhibits polyadenylation2009
Author(s)
Kiefer H, Mizutani A, Iemura A, Natsume T, Ando H, Kuroda Y, Mikoshiba K
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Journal Title
J.Biol.Chem. 284
Pages: 10694-10705
Related Report
Peer Reviewed
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