Molecular network supporting chromosomal stability
| Project/Area Number |
21570193
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Tohoku University |
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Principal Investigator |
TANAKA Kozo 東北大学, 加齢医学研究所, 教授 (00304452)
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| Co-Investigator(Kenkyū-buntansha) |
YASUI Akira 東北大学, 加齢医学研究所, 教授 (60191110)
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| Research Collaborator |
ITOH Go 東北大学, 加齢医学研究所, 助教 (60607563)
KANNO Shinichiro 東北大学, 加齢医学研究所, 講師 (10400417)
TANAKA Tomoyuki 英国ダンディー大学, 生命科学科, 教授 (50227154)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 細胞周期 / 染色体分配 / 細胞分裂 / キネトコア / 微小管 |
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| Research Abstract |
We searched for molecules involved in chromosomal stability, and identified a novel molecule, CAMP(chromosome alignment-maintaining phosphoprotein ; C13orf8, ZNF828). CAMP is supposed to contribute to chromosome segregation through the maintenance of kinetochore-microtubule attachment. Mutations in CAMP were suggested to be related to oncogenesis.
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Report
(4 results)
Research Products
(47 results)
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[Journal Article] Kinetochore-dependent microtubule rescue ensures their efficient and sustained interactions in early mitosis2011
Author(s)
Gandhi, S, R, Gierlinski, M, Mino, A, Tanaka, K, Kitamura, E, Clayton, L, and Tanaka, T, U
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Journal Title
Dev Cell
Volume: 21
Pages: 920-933
Related Report
Peer Reviewed
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[Journal Article] Global analysis of core histones reveals nucleosomal surfaces required for chromosome bi-orientation2011
Author(s)
†Kawashima, S, †Nakabayashi, Y(†equally contributors), Matsubara, K, Sano, N, Enomoto, T, * Tanaka, K, * Seki, M, and * Horikoshi, M(* joint corresponding authors).
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Journal Title
EMBO J
Volume: 30
Pages: 3353-3367
Related Report
Peer Reviewed
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[Journal Article] CAMP(C13orf8, ZNF828)is a novel regulator of kinetochore-microtubule attachment2011
Author(s)
toh, G, Kanno, S, Uchida, K, S, K, Chiba, S, Sugino, S, Watanabe, K, Mizuno, K, Yasui, A, Hirota, T, and Tanaka, K
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Journal Title
EMBO J
Volume: 30
Pages: 130-144
Related Report
Peer Reviewed
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[Journal Article] Kinetochores generate microtubules with distal plus ends : their roles and limited lifetime in mitosis2010
Author(s)
Kitamura, E, Tanaka, K, Komoto, S(tequally contributors), Kitamura, Y, Antony, C, and Tanaka, T, U
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Journal Title
Dev Cell
Volume: 18
Pages: 248-259
Related Report
Peer Reviewed
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