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Functional analysis of nuclear envelope targeting plasma membrane Proteins : using EGF family proteins

Research Project

Project/Area Number 21570196
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cell biology
Research InstitutionOsaka University

Principal Investigator

HIEDA Miki  大阪大学, 大学院・医学系研究科, 特任助教(常勤) (00380254)

Co-Investigator(Renkei-kenkyūsha) KIMURA Hiroshi  大阪大学, 大学院・生命機能研究科, 准教授 (30241392)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords細胞構造・機能 / 細胞核 / 転写調節 / 細胞遊走 / 癌細胞遊走 / amphiregulin / 核膜タンパク質 / SUN / nesprin / LINC complex / H3K9me3 / 細胞運動 / 核膜 / EGFファミリー
Research Abstract

An EGF family member, amphiregulin, which has been suggested to play role(s) in breast cancer, is expressed on the cell surface in pro-form. Shedding stimuli result in release of soluble EGFR ligand and migration of the pro-form to the nuclear envelope. This study demonstrates that nuclear envelope-localized proAREG activates breast cancer cell migration and the activation of cell migration does not require EGFR function, but does occur concomitantly with an alteration of histone modification.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (53 results)

All 2012 2011 2010 2009

All Journal Article (29 results) (of which Peer Reviewed: 29 results) Presentation (24 results)

  • [Journal Article] Nuclear envelope-localized EGF family protein amphiregulin activates breast cancer cell migration in an EGF-like domain independent manner2012

    • Author(s)
      Tanaka, H., Nishioka, Y., Yokoyama Y., Higashiyama S., Matsuura, N., Matsuura, S., Hieda, M.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 420 Issue: 4 Pages: 721-726

    • DOI

      10.1016/j.bbrc.2012.03.045

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Breaking the HAC Barrier : Histone H3K9 acetyl/ methyl balance regulates CENP-A assembly2012

    • Author(s)
      Ohzeki J-i, Bergmann JH, Kouprina N, Noskov VN, Nakano M, Kimura H, Earnshaw WC, Larionov V, and Masumoto H
    • Journal Title

      EMBO J

      Volume: (in press) Issue: 10 Pages: 2391-2402

    • DOI

      10.1038/emboj.2012.82

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transition of Chromatin Status During The Recovery Process from Drought Stress in Arabidopsis thaliana2012

    • Author(s)
      Kim J-M, To TK, Ishida J, Matsui A, Kimura H, Seki M
    • Journal Title

      Plant Cell Physiol

      Volume: 53 Issue: 5 Pages: 847-856

    • DOI

      10.1093/pcp/pcs053

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Roles of histone H3K9 methyltransferases during Drosophila spermatogenesis2012

    • Author(s)
      Ushijima Y, Inoue YH, Konishi T, Kitazawa D, Yoshida H, Shimaji K, Kimura H, Yamaguchi M
    • Journal Title

      Chromosome Research

      Volume: 3 Issue: 3 Pages: 319-31

    • DOI

      10.1007/s10577-012-9276-1

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic Engineering : Histone H3K9 acetylation is compatible with kinetochore structure and function2012

    • Author(s)
      Bergmann JH, Jakubsche JN, Martins NM, Kagansky A, Nakano M, Kimura H, Kelly DA, Turner BM, Masumoto H, Larionov V, and Earnshaw WC
    • Journal Title

      J Cell Sci

      Volume: 125 Issue: 2 Pages: 411-421

    • DOI

      10.1242/jcs.090639

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polycomb Associates Genome-wide with a Specific RNA Polymerase II Variant2012

    • Author(s)
      Brookes E, de Santiago I, Hebenstreit D, Morris KJ, Carroll T, Xie SQ, Stock JK, Heidemann M, Eick D, Nozaki N, Kimura H, Ragoussis J, Teichmann SA, and Pombo A
    • Journal Title

      and Regulates Metabolic Genes in ESCs. Cell Stem Cell

      Volume: 10 Issue: 2 Pages: 157-170

    • DOI

      10.1016/j.stem.2011.12.017

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fluorescence cell imaging and manipulation using conventional halogen lamp microscopy2011

    • Author(s)
      Yamagata K
    • Journal Title

      PLoS One

      Volume: 7 Issue: 2 Pages: e31638-e31638

    • DOI

      10.1371/journal.pone.0031638

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Platelet-Derived Growth Factor Regulates Breast Cancer Progression via・-Catenin Expression2011

    • Author(s)
      Yokoyama, Y., Mori, S., Hamada, Y., Hieda, M., Kawaguchi, N., Shaker, M., Tao, Y., Yoshidome, K., Tsujimoto, M., Matsuura, N.
    • Journal Title

      Pathobiology

      Volume: 78 Issue: 5 Pages: 253-260

    • DOI

      10.1159/000328061

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Submembranous septins as relatively stable components of actin-based membrane skeleton2011

    • Author(s)
      A.Hagiwara, Y.Tanaka, R.Hikawa, N.Morone, A.Kusumi, H.Kimura, M.Kinoshita
    • Journal Title

      Cytoskeleton

      Volume: 68 Issue: 9 Pages: 512-525

    • DOI

      10.1002/cm.20528

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tracking epigenetic histone modifications in single cells using Fab-based live endogenous modification labeling2011

    • Author(s)
      Hayashi-Takanaka Y
    • Journal Title

      Nucleic Acids Res

      Volume: 39 Issue: 15 Pages: 6475-6488

    • DOI

      10.1093/nar/gkr343

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Crystal structure of the human centromeric nucleosome containing CENP-A2011

    • Author(s)
      Tachiwana H, Kagawa W, Shiga T, Osakabe A, Miya Y, Saito K, Hayashi-Takanaka Y, Oda T, Sato M, Park SY, Kimura H, Kurumizaka H
    • Journal Title

      Nature

      Volume: 476 Issue: 7359 Pages: 232-235

    • DOI

      10.1038/nature10258

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structures of human nucleosomes containing major histone H3 variants2011

    • Author(s)
      Tachiwana H, Osakabe A, Shiga T, Miya Y, Kimura H, Kagawa W, Kurnmizaka H
    • Journal Title

      Acta Crystallogr.D Biol.Crystallogr.

      Volume: 67 Issue: 6 Pages: 578-583

    • DOI

      10.1107/s0907444911014818

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of myosin II/ actin turnover at the contractile ring induces slower furrowing in dividing HeLa cells2011

    • Author(s)
      Kondo T, Hamao K, Kamijo K, Kimura H, Morita M, Takahashi M, and Hosoya H
    • Journal Title

      Biochem J

      Volume: 435 Issue: 3 Pages: 569-576

    • DOI

      10.1042/bj20100837

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of claudin species-specific dynamics in reconstitution and remodeling of the zonula occludens2011

    • Author(s)
      Yamazaki, Y., Tokumasu, R., Kimura H., and Tsukita S.
    • Journal Title

      Mol. Biol. Cell

      Volume: 22 Issue: 9 Pages: 1495

    • DOI

      10.1091/mbc.e10-12-1003

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Arabidopsis HDA6 regulates locus-directed heterochromatin silencing in cooperation with MET12011

    • Author(s)
      To TK, Kim JM, Matsui A, Kurihara Y, Morosawa T, Ishida J, Tanaka M, Endo T, Kakutani T, Toyoda T, Kimura H, Yokoyama S, Shinozaki K, Seki M
    • Journal Title

      PLoS Genetics

      Volume: 7 Issue: 4 Pages: e1002055-e1002055

    • DOI

      10.1371/journal.pgen.1002055

    • NAID

      130006996644

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Broad chromosomal domains of histone modification patterns in C2011

    • Author(s)
      Liu T, Rechtsteiner A, Egelhofer TA, Vielle A, Latorre I, Cheung MS, Ercan S, Ikegami K, Jensen M, Kolasinska-Zwierz P, Rosenbaum H, Shin H, Taing S, Takasaki T, Iniguez AL, Desai A, Dernburg AF, Kimura H, Lieb JD, Ahringer J, Strome S, and Liu XS
    • Journal Title

      elegans. Genome Res

      Volume: 21 Issue: 2 Pages: 227-236

    • DOI

      10.1101/gr.115519.110

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic engineering shows H3K4me2 is required for HJURP targeting and CENP-A assembly on a synthetic human kinetochore2011

    • Author(s)
      Bergmann JH, Rodriguez MG, Martins NM, Kimura H, Kelly DA, Masumoto H, Larionov V, Jansen LE, and Earnshaw WC
    • Journal Title

      EMBO J

      Volume: 30 Issue: 2 Pages: 328-340

    • DOI

      10.1038/emboj.2010.329

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Autocatalytic differentiation of epigenetic modifications within the Arabidopsis genome2010

    • Author(s)
      Inagaki S, Miura-Kamio A, Nakamura Y, Lu F, Cui X, Cao X, Kimura H, Saze H, and Kakutani T
    • Journal Title

      EMBO J

      Volume: 29 Issue: 20 Pages: 3496-3506

    • DOI

      10.1038/emboj.2010.227

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Survivin reads phosphorylated histone H3 threonine 3 to activate the mitotic kinase Aurora B2010

    • Author(s)
      Kelly AE, Ghenoiu C, Xue JZ, Zierhut C, Kimura H, and Funabiki H
    • Journal Title

      Science

      Volume: 330 Issue: 6001 Pages: 235-239

    • DOI

      10.1126/science.1189505

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The histone H3K36 methyltransferase MES-4 acts epigenetically to transmit the memory of germline gene expression to progeny2010

    • Author(s)
      Rechtsteiner A, Ercan S, Takasaki T, Phippen TM, Egelhofer TA, Wang W, Kimura H, Lieb JD, and Strome S
    • Journal Title

      PLoS Genet

      Volume: 6 Issue: 9 Pages: e1001091-e1001091

    • DOI

      10.1371/journal.pgen.1001091

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oncogenesis by sequestration of CBP/ p300 in transcriptionally inactive hyperacetylated chromatin domains2010

    • Author(s)
      Reynoird N, Schwartz BE, Delvecchio M, Sadoul K, Meyers D, Mukherjee C, Caron C, Kimura H, Rousseaux S, Cole PA, Panne D, French CA, and Khochbin S
    • Journal Title

      EMBO J.

      Volume: 29 Issue: 17 Pages: 2943-2952

    • DOI

      10.1038/emboj.2010.176

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Trans-generational epigenetic regulation of C. elegans primordial germ cells2010

    • Author(s)
      Furuhashi H, Takasaki T, Rechtsteiner A, Li T, Kimura H, Checchi PM, Strome S, and Kelly WG
    • Journal Title

      Epigenetics Chromatin

      Volume: 3 Issue: 1 Pages: 15-15

    • DOI

      10.1186/1756-8935-3-15

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation2010

    • Author(s)
      Nozawa R, Nagao K, Masuda H, Iwasaki O, Hirota T, Nozaki N, Kimura H. and Obuse C
    • Journal Title

      Nat. Cell Biol

      Volume: 12 Issue: 7 Pages: 719-727

    • DOI

      10.1038/ncb2075

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structural basis of instability of the nucleosome containing a testis-specific histone variant, human H3T2010

    • Author(s)
      Tachiwana H, Kagawa W, Osakabe A, Kawaguchi K, Shiga T, Hayashi -Takanaka Y, Kimura H, and Kurumizaka H
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 107 Issue: 23 Pages: 10454-10459

    • DOI

      10.1073/pnas.1003064107

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Histone H1 null vertebrate cells exhibit altered nucleosome architecture2010

    • Author(s)
      Hashimoto H, Takami Y, Sonoda E, Iwasaki T, Iwano H, Tachibana M, Takeda S, Nakayama T, Kimura H, and Shinkai Y
    • Journal Title

      Nucleic Acids Res

      Volume: 38 Issue: 11 Pages: 3533-3545

    • DOI

      10.1093/nar/gkq076

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proviral silencing in embryonic stem cells requires the histone methyltrans-ferase ESET2010

    • Author(s)
      Matsui, T., Leung, D., Miyashita, H., Maksakova, I.A., Miyachi, H., Kimura, H., Tachibana, M., Lorincz, M.C., Shinkai, Y
    • Journal Title

      Nature

      Volume: 464 Issue: 7290 Pages: 927-931

    • DOI

      10.1038/nature08858

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transduction of RNA-directed DNA methylation signals to repressive histone marks in Arabidopsis thaliana2010

    • Author(s)
      Numa H, Kim JM, Matsui A, Kurihara Y, Morosawa T, Ishida J, Mochizuki Y, Kimura H, Shinozaki K, Toyoda T, Seki M, Yoshikawa M, and Habu Y
    • Journal Title

      EMBO J

      Volume: 29 Issue: 2 Pages: 352-362

    • DOI

      10.1038/emboj.2009.374

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Visualizing histone modifications in living cells : spatiotemporal dynamics of H3 phosphorylation during interphase2009

    • Author(s)
      Hayashi-Takanaka Y, Yamagata K, Nozaki N, and Kimura H
    • Journal Title

      J Cell Biol

      Volume: 187 Issue: 6 Pages: 781-790

    • DOI

      10.1083/jcb.200904137

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inactive X chromosome-specific histone H3 modifications and CpG hypomethylation flank a chromatin boundary between an X-inactivated and an escape gene2009

    • Author(s)
      Goto Y and Kimura H
    • Journal Title

      Nucleic Acids Res

      Volume: 37 Issue: 22 Pages: 7416-7428

    • DOI

      10.1093/nar/gkp860

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] in vitro核膜内膜タンパク質局在化assay系の構築、(Development of an in vitro nuclear membrane protein targeting system)2011

    • Author(s)
      野村菜美子、西岡優、松浦成昭、松浦脩治、檜枝美紀
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜、神奈川県横浜市
    • Year and Date
      2011-12-15
    • Related Report
      2011 Final Research Report
  • [Presentation] in vitro核膜内膜タンパク質局在化assay系の構築2011

    • Author(s)
      野村菜美子、西岡優、松浦成昭、松浦脩治、檜枝美紀
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜、神奈川
    • Year and Date
      2011-12-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] in vitro膜タンパク質核膜局在化アッセイ系の構築2011

    • Author(s)
      野村菜美子、西岡優、松浦成昭、松浦脩治、檜枝美紀
    • Organizer
      第10回核ダイナミクス研究会
    • Place of Presentation
      クラッセホテル北広島、北海道北広島市
    • Year and Date
      2011-10-27
    • Related Report
      2011 Final Research Report
  • [Presentation] in vitro膜タンパク質核膜局在化アッセイ系の構2011

    • Author(s)
      野村菜美子、西岡優、松浦成昭、松浦脩治、檜枝美紀
    • Organizer
      第10回核ダイナミクス研究会
    • Place of Presentation
      クラッセホテル北広島、北海道北広島市
    • Year and Date
      2011-10-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Nuclear envelope localized EGF receptor ligand, amphiregulin activates the cell migration via chromatin reorganization2011

    • Author(s)
      Miki Hieda, Yuhki Yokoyama, Yu Nishioka, Hisae Tanaka, Shigeki Higashiyama, Nariaki Matsuura, Shuji Matsuura
    • Organizer
      EMBO Conference Series Nuclear Structure & Dynamics
    • Place of Presentation
      L' sle sur la Sorgue, France
    • Year and Date
      2011-09-30
    • Related Report
      2011 Final Research Report
  • [Presentation] Nuclear envelope localized EGF receptor ligand, amphiregulin activates the cell migration via chromatin reorganization2011

    • Author(s)
      Miki Hieda, Yuhki Yokoyama, Yu Nishioka, Hisae Tanaka, Shigeki Higashiyama, Nariaki Matsuura, Shuji Matsuura
    • Organizer
      EMBO Conference Series Nuclear Structure & Dynamics
    • Place of Presentation
      L'sle sur la Sorgue, France
    • Year and Date
      2011-09-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] Nuclear envelope localized EGF receptor ligand, amphiregulin activates the cell migration via chromatin reorganization2011

    • Author(s)
      Miki Hieda
    • Organizer
      EMBL Blue Seminar
    • Place of Presentation
      The European Molecular Biology Laboratory, Heidelberg, Germany
    • Year and Date
      2011-09-26
    • Related Report
      2011 Final Research Report
  • [Presentation] Nuclear envelope localized EGF receptor ligand, amphiregulin activates the cell migration via chromatin reorganization2011

    • Author(s)
      檜枝美紀
    • Organizer
      EMBL Blue Seminar
    • Place of Presentation
      The European Molecular Biology Laboratory, Heidelberg, Germany(招待講演)
    • Year and Date
      2011-09-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] 核細胞質間コミュニケーション・核からの情報発信2011

    • Author(s)
      檜枝美紀
    • Organizer
      第1回異分野融合ワークショップ
    • Place of Presentation
      情報通信研究機構未来ICT研究所(KARC)、兵庫県神戸市
    • Year and Date
      2011-09-08
    • Related Report
      2011 Final Research Report
  • [Presentation] 核細胞質間コミュニケーション・核からの情報発信2011

    • Author(s)
      檜枝美紀
    • Organizer
      第1回異分野融合ワークショップ
    • Place of Presentation
      情報通信研究機構未来ICT研究所(KARC)兵庫県神戸市(招待講演)
    • Year and Date
      2011-09-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] EGFファミリー増殖因子amphiregulinの核膜局在化による細胞遊走能の調節機構、(Nuclear envelope localized an EGFR ligand, amphiregulin regulates cell migration)2011

    • Author(s)
      檜枝美紀、横山雄起、西岡優、田中ひさえ、東山繁樹、松浦成昭、松浦脩治
    • Organizer
      第63回日本細胞生物学会大会
    • Place of Presentation
      北海道大学、北海道札幌市
    • Year and Date
      2011-06-27
    • Related Report
      2011 Final Research Report
  • [Presentation] EGFファミリー増殖因子amphiregulinの核膜局在化による細胞遊走能の調節機構2011

    • Author(s)
      檜枝美紀、横山雄起、西岡優、田中ひさえ、東山繁樹、松浦成昭、松浦脩治
    • Organizer
      第63回日本細胞生物学会大会
    • Place of Presentation
      北海道大学、札幌
    • Year and Date
      2011-06-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] amphiregulin is translocated from the plasma membrane to the nuclear envelope and regulates cell migration2011

    • Author(s)
      Miki Hieda, An EGFR ligand
    • Organizer
      6th Asian-Pacific Organization for Cell Biology Congress(第6回アジア太平洋国際細胞生物学会)
    • Place of Presentation
      Manila, Philippines
    • Year and Date
      2011-02-26
    • Related Report
      2011 Final Research Report
  • [Presentation] An EGFR ligand, amphiregulin is translocated from the plasma membrane to the nuclear envelope and regulates cell migration2011

    • Author(s)
      Miki Hieda
    • Organizer
      第6回アジア太平洋国際細胞生物学会
    • Place of Presentation
      マニラ、フィリッピン(招待講演)
    • Year and Date
      2011-02-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] A nuclear envelope localized EGFR ligand, amphiregulin, up-regulates the cancer cell migration2011

    • Author(s)
      Yuhki Yokoyama, Miki Hieda, Hisae Tanaka, Yu Nishioka, Shigeki Higashiyama, and Nariaki Matsuura
    • Organizer
      International Symposium Physicochemical Field for Cenetic Activities
    • Place of Presentation
      淡路夢舞台国際会議場、兵庫県淡路市
    • Year and Date
      2011-01-26
    • Related Report
      2011 Final Research Report
  • [Presentation] A nuclear envelope localized EGFR ligand, amphiregulin, up-regulates the cancer cell migration2011

    • Author(s)
      Yuhki Yokoyama, Miki Hieda, Hisae Tanaka, Yu Nishioka, Shigeki Higashiyama, Nariaki Matsuura
    • Organizer
      International Symposium Physicochemical Field for Cenetic Activities
    • Place of Presentation
      淡路夢舞台国際会議場、兵庫
    • Year and Date
      2011-01-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cytoplasmic tail of EGFR ligand, amphiregulin regulates histone modification and induces the cell migration2010

    • Author(s)
      Hisae Tanaka, Miki Hieda, Yu Nishioka, Shigeki Higashiyama, Nariaki Matsuura
    • Organizer
      Nuclear Organization & Function, Cold Spring Harbr Symposium on Quantitative Biology
    • Place of Presentation
      Cold Spring Harbor Laboratory, NY, USA
    • Year and Date
      2010-06-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cytoplasmic tail of EGFR ligand, amphiregulin regulates histone modification and induces the cell migration2010

    • Author(s)
      Hisae Tanaka, Miki Hieda, Yu Nishioka, Shigeki Higashiyama, Nariaki Matsuura
    • Organizer
      75th Nuclear Organization & Function, Cold Spring Harbor Symposium
    • Place of Presentation
      Cold Spring Harbor Laboratory, NY, USA
    • Year and Date
      2010-06-04
    • Related Report
      2011 Final Research Report
  • [Presentation] Intracellular domain of an EGFR ligand, amphiregulin regulates cell migration2010

    • Author(s)
      Hisae Tanaka, Miki Hieda, Yu Nishioka, Shigeki Higashiyama, Nariaki Matsuura
    • Organizer
      第62回細胞生物学会大会
    • Place of Presentation
      大阪国際会議場、大阪
    • Year and Date
      2010-05-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Intracellular domain of an EGFR ligand, amphiregulin regulates cell migration2010

    • Author(s)
      Hisae Tanaka, Miki Hieda, Yu Nishioka, Shigeki Higashiyama, Nariaki Matsuura
    • Organizer
      第62回日本細胞生物学会大会
    • Place of Presentation
      大阪国際会議場、大阪府吹田市
    • Year and Date
      2010-05-19
    • Related Report
      2011 Final Research Report
  • [Presentation] Reverse signaling of an EGFR ligand, amphiregulin, suppresses breast cancer cell proliferation and induces the cellmigration2010

    • Author(s)
      Hisae Tanaka, Miki Hieda, Yu Nishioka, Shigeki Higashiyama, Nariaki Matsuura
    • Organizer
      AACR/ JCA Joint Conference : Cancer Genomics, Epigenomics, and the Development of Novel Therapeutics
    • Place of Presentation
      Waikoloa, Hawaii、USA
    • Year and Date
      2010-02-08
    • Related Report
      2011 Final Research Report
  • [Presentation] Reverse signaling of an EGFR ligand, amphiregulin, suppresses breast cancer cell proliferation and induces the cell migration2010

    • Author(s)
      檜枝美紀
    • Organizer
      AACR/JCA Joint Conference : Cancer Genomics, Epigenomics, and the Development of Novel Therapeutics
    • Place of Presentation
      Waikoloa, Hawaii, USA
    • Year and Date
      2010-02-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] HB-EGFの細胞膜-ER/核膜間メンブレントフィック経路の解析2009

    • Author(s)
      檜枝美紀
    • Organizer
      日本細胞生物学会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2009-06-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] HB-EGFの細胞膜-ER/核膜間メンブレントフィック経路の解析2009

    • Author(s)
      Miki Hieda, Michiko Koizumi, Tomohiko Taguchi, Taro Tachibana, Nariaki Matsuura, Shigeki Higashiyama
    • Organizer
      第61回日本細胞生物学会大会
    • Place of Presentation
      名古屋国際会議場、愛知県名古屋市
    • Year and Date
      2009-06-03
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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