| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
An EGF family member, amphiregulin, which has been suggested to play role(s) in breast cancer, is expressed on the cell surface in pro-form. Shedding stimuli result in release of soluble EGFR ligand and migration of the pro-form to the nuclear envelope. This study demonstrates that nuclear envelope-localized proAREG activates breast cancer cell migration and the activation of cell migration does not require EGFR function, but does occur concomitantly with an alteration of histone modification.
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