Mechanosensing system for regulating the cell morphology during cytokinesis
Project/Area Number |
21570199
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Cell biology
|
Research Institution | Yamaguchi University |
Principal Investigator |
|
Co-Investigator(Renkei-kenkyūsha) |
UYEDA Taro バイオメディシナル情報研究センター, 副研究センター長 (90356551)
IWADATE Yoshiaki 山口大学, 大学院・医学系研究科, 准教授 (40298170)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 細胞質分裂 / アクチン / ミオシン / 細胞分裂 / 細胞性粘菌 / メカノセンシング |
Research Abstract |
Cells always monitor their size and shape. The excess shape change, which may result in tearing the cell membrane, should be put back by a feedback mechanism. Such mechanism may guarantee the equal division of cell volume during cytokinesis. In this study, we found actin filaments act as a mechanosensor in Dictyostelium cells. Additionally, myosin and PTEN also participated this function. The defects of this mechanism induced abnormal cytokinesis.
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Report
(4 results)
Research Products
(32 results)