| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
This study suggests that Avt3 and Avt4 in Saccharomyces cerevisiae AVT transporter family are redundantly involved in the export of a broad range of neutral amino acids from vacuoles, and that Avt4 but not Avt3 functions to extrude vacuolar basic amino acids during nitrogen starvation. On the other hand, Avt1 was suggested to uptake various neutral amino acids and histidine into vacuoles. In addition, we newly identified 13 transporters localized to the vacuolar membrane, and found that some of these transporters may be involved in the vacuolar amino acid transport.
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