The molecular mechanism and the physiological role of vacuolar amino acid pool formation
| Project/Area Number |
21570200
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Ehime University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
FUJIKI Yuki 埼玉大学, 大学院・理工学研究科, 助教 (00414011)
KAKINUMA Yoshimi 愛媛大学, 農学部, 教授 (80134394)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 細胞機能 / 構造 / 液胞 / アミノ酸トランスポーター / VBAファミリー / AVTファミリー / Major Facilitator Superfamily |
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| Research Abstract |
This study suggests that Avt3 and Avt4 in Saccharomyces cerevisiae AVT transporter family are redundantly involved in the export of a broad range of neutral amino acids from vacuoles, and that Avt4 but not Avt3 functions to extrude vacuolar basic amino acids during nitrogen starvation. On the other hand, Avt1 was suggested to uptake various neutral amino acids and histidine into vacuoles. In addition, we newly identified 13 transporters localized to the vacuolar membrane, and found that some of these transporters may be involved in the vacuolar amino acid transport.
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Report
(4 results)
Research Products
(45 results)
