A potential role of mitochondria-mediated signaling in induction of malignancy and stemness by TGF.
| Project/Area Number |
21570205
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Showa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MORI Kazunori 昭和大学, 薬学部, 助教 (60349040)
ISHIKAWA Fumihiro 昭和大学, 薬学部, 助教 (60515667)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ミトコンドリア / CREB / HMGA2 / CHOP-10 / TGFβ / 膜電位 / 活性酸素 / チオレドキシン / プロテインキチーゼC / MMP9 |
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| Research Abstract |
cAMP-responsive element-binding protein(CREB) was found to be activated and cause morphological disruption of epithelial cells under mitochondrial dysfunction. Of note, activated CREB upregulated HMGA2, resulting in activation of epithelial-mesenchymal transition(EMT) program and modulation of integrin. 1 expression. Overall, the results suggest that mitochondrial dysfunction potentially mediates TGF-.-induced malignancy and contributes to neoplastic transformation of epithelial cells.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Importance of mitochondrial dysfunction in oxidative stress responses : A comparative study of gene expression profiles2011
Author(s)
Shibanuma, M., Inoue, A., Ushida, K., Uchida, T., Ishikawa, F., Mori, K., and Nose, K.
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Journal Title
Free Radic. Res
Volume: 45
Pages: 672-680
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[Journal Article] Gene expression profiling identifies a role for CHOP-10 during inhibition of the mitochondrial respiratory chain2009
Author(s)
Ishikawa, F., Akimoto, T., Yamamoto, H., Araki, Y., Yoshie, T., Mori, K., Hayashi, H., Nose, K., and Shibanuma, M.
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Journal Title
J. Biochem
Volume: 146
Pages: 123-132
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[Journal Article] Competitive nuclear export of cyclin D1 and Hic-5 regulates anchorage-dependence of cell growth and survival2009
Author(s)
Mori, K., Hirao, E., Toya, Y., Oshima, Y., Ishikawa, F., Nose, K., and Shibanuma, M.
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Journal Title
Mol. Biol Cell
Volume: 20
Pages: 218-232
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[Presentation] Mitochondria-mediated signaling cascade plays a role in the regulation of gene expression by TGF2010
Author(s)
Shibanuma, M., Kaneko, E., Sugimoto, T., Wakamatsu, M., Mori, K., Ishikawa, F.
Organizer
第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
Place of Presentation
神戸
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[Presentation] Transcriptional induction of MMP10 by TGF. mediated by MEF2 and class IIa HDACs2009
Author(s)
Ishikawa, F., Kaneko, E., Yoshie, T., Nose, K., Shibanuma, M.
Organizer
Keystone Symposia
Place of Presentation
Vancouver, British Columbia, Canada
Year and Date
2009-03-17
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