| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
Overexpression of active ATF6 induces apoptosis in myoblast cells. ATF6 up-regulated WW domain binding protein 1(WBP1), which was found to be proapoptotic. Overexpression of active ATF6 or WBP1 caused a specific decrease in an antiapoptotic protein, myeloid cell leukemia sequence 1(Mcl-1). Cells treated with ER stressors underwent apoptosis and exhibited an up-regulation of WBP1 and decreased Mcl-1.These results suggest that ATF6 mediates apoptosis via specific reduction of Mcl-1 levels through the up-regulation of WBP1.
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