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Molecular mechanism of centromere clustering at SPB in the fission yeast

Research Project

Project/Area Number 21570212
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cell biology
Research InstitutionNational Institute of Information and Communications Technology

Principal Investigator

MAEKAWA Hiromi  独立行政法人情報通信研究機構, 未来ICT研究所・バイオICT研究室, 専攻研究員 (80399683)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywords遺伝子 / シグナル伝達 / 発現制御 / 蛋白質
Research Abstract

We demonstrated that N-terminal domain of Sad1, an SPB component in S. pombe, is required for efficient re-accumulation of kinetochore components when cells return to mitotic cycle from meiotic cycle and thereby facilitate re-establishment of the centromere clustering at SPB. We also showed that inner nuclear membrane protein Ima1 has no apparent role in the centromere-SPB interaction, but instead is required for the formation and maintenance of nuclear membrane structure and the cell cycle progression.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (13 results)

All 2011 2010 2009 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (10 results) Remarks (2 results)

  • [Journal Article] Inner nuclear membrane protein Ima1 is dispensable for intranuclear positioning of centromeres2011

    • Author(s)
      Hiraoka Y, Maekawa H, Asakawa H, Chikashige Y, Kojidani T, Osakada H, Matsuda A, Haraguchi T
    • Journal Title

      Genes Cells

      Volume: 16 Issue: 10 Pages: 1000-1011

    • DOI

      10.1111/j.1365-2443.2011.01544.x

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Presentation] Inner nuclear membrane proteins in the fission yeast2011

    • Author(s)
      前川裕美
    • Organizer
      International Symposium Physicochemical Field for Genetic Activities
    • Place of Presentation
      淡路夢舞台国際会議場、兵庫県淡路市
    • Year and Date
      2011-01-24
    • Related Report
      2011 Final Research Report
  • [Presentation] Inner nuclear membrane proteins in the fission yeast.2011

    • Author(s)
      前川裕美
    • Organizer
      International Symposium Physicochemical Field for Genetic Activities
    • Place of Presentation
      淡路夢舞台国際会議場、兵庫県
    • Year and Date
      2011-01-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Inner nuclear membrane proteins required for positioning chromosomes in the nucleus2010

    • Author(s)
      平岡泰
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド、神戸市
    • Year and Date
      2010-12-09
    • Related Report
      2011 Final Research Report
  • [Presentation] Inner nuclear membrane proteins required for positioning chromocomes in the nucleus2010

    • Author(s)
      平岡泰
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド、兵庫県
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 分裂酵母の核内膜蛋白質の核構造維持における役割2010

    • Author(s)
      前川裕美
    • Organizer
      酵母遺伝学フォーラム第43回研究報告会
    • Place of Presentation
      ならまちセンター、奈良市
    • Year and Date
      2010-09-09
    • Related Report
      2011 Final Research Report
  • [Presentation] 分裂酵母の核内膜蛋白質の核構造維持における役割2010

    • Author(s)
      前川裕美
    • Organizer
      酵母遺伝学フォーラム第43回研究報告会
    • Place of Presentation
      ならまちセンター、奈良県
    • Year and Date
      2010-09-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] The inner nuclear membrane proteins influence nuclear envelope structure in the fission yeast2010

    • Author(s)
      前川裕美
    • Organizer
      日本細胞生物学会第62回大会
    • Place of Presentation
      大阪国際会議場、大阪市
    • Year and Date
      2010-05-21
    • Related Report
      2011 Final Research Report
  • [Presentation] The inner nuclear membrane proteins influence nuclear envelope structure in the fission yeast.2010

    • Author(s)
      前川裕美
    • Organizer
      日本細胞生物学会第62回大会
    • Place of Presentation
      大阪国際会議揚、大阪府
    • Year and Date
      2010-05-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 減数分裂期で相同染色体が相互認識する仕組み2010

    • Author(s)
      丁大橋
    • Organizer
      第27回染色体ワークショップ
    • Place of Presentation
      御殿場高原時之栖、静岡県
    • Year and Date
      2010-01-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] Large-scale localization of protein components of nuclear structures in fission yeast2009

    • Author(s)
      Yasushi Hiraoka
    • Organizer
      The 5th International Fission Yeast Meeting
    • Place of Presentation
      National Olympics Memorial Youth Center, Tokyo, Japan
    • Year and Date
      2009-10-30
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www-karc.nict.go.jp/w131103/CellMagic/index.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www-karc.nict.go.jp/w131103/CellMagic/index.html

    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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