Mechanism of inner ear and semicircular canalmorphogenesis

• Project/Area Number: 21570216
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Developmental biology
• Research Institution: Tohoku University
• Principal Investigator: JUN-ICHI Funahashi 東北大学, 加齢医学研究所, 准教授 (00270827)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 器官形成 / 形態形成 / ニワトリ / ゼブラフィッシュ / Sox5 / ニワトリ胚 / 三次元タイムラプス / トランスジェニック / 三次元タイムラプス解析 / gallery / ポジショナルクローニング

Research Abstract

Semicircular canals are intriguing model system to study the mechanism of morphogenesis. In this study, two model organisms, zebrafish and chick are used. Utilizing each of its own advantage, cellular and histological analysis was carried out with cutting edge imaging technology. In parallel to these analyses, cloning and functional analysis of the genes related to morphogenesis was done. As a result, it is revealed that Sox5 gene plays a critical roll in semicircular canal morphogenesis.

Research Products

• [Journal Article] Electroporation: Past, present and future (2013)
  • Author(s): Harukazu Nakamura and Junichi Funahashi
  • Journal Title: Develop. Growth Differ Volume: 55 Issue: 1 Pages: 15-19
  • DOI: 10.1111/dgd.12012
  • NAID: 40019549265
  • Peer Reviewed
• [Presentation] Time-lapse imaging system with shell-less culture chamber (2012)
  • Author(s): 舟橋淳一 、仲村春和
  • Organizer: 7th International Chick meeting
  • Place of Presentation: 名古屋市
• [Presentation] Time-lapse imaging system with shell-less culture chamber (2012)
  • Author(s): 舟橋淳一、仲村春和（舟橋淳一）
  • Organizer: 7th International Chick meeting
  • Place of Presentation: 愛知県名古屋市
• [Presentation] 光るゼブラフィッシュで"観る"内耳の発生 (2011)
  • Author(s): 舟橋淳一
  • Organizer: 加齢研シンポジウム「発生生物学の適応放散」
  • Place of Presentation: 仙台市
• [Presentation] ssential roll of SOX5 in the semicircular canal development of zebrafish (2011)
  • Author(s): 谷野俊平、阿部玄武、川上浩一、仲村春和、舟橋淳一
  • Organizer: 第44回日本発生生物学 会年会
  • Place of Presentation: 宜野湾市
• [Presentation] 光るゼブラフィッシュで”観る”内耳の発生 (2011)
  • Author(s): 舟橋淳一
  • Organizer: 加齢研シンポジウム「発生生物学の適応放散」
  • Place of Presentation: 宮城県仙台市
• [Presentation] Essential roll of SOX5 in the semicircular canal development of zebrafish (2011)
  • Author(s): 谷野俊平、阿部玄武、川上浩一、仲村春和、舟橋淳一（舟橋淳一）
  • Organizer: 第４４回日本発生生物学会年会
  • Place of Presentation: 沖縄県宜野湾市
• [Presentation] 三半規管形成機構におけるSox5の機能解析 (2010)
  • Author(s): 谷野俊平, 阿部玄武, 川上浩一, 仲村春和, 舟橋淳一
  • Organizer: 第33回日本分子生物学会
  • Place of Presentation: 神戸国際展示場
  • Year and Date: 2010-12-10
• [Presentation] 共焦点三次元タイムラプス・イメージンク (2010)
  • Author(s): 舟橋淳一
  • Organizer: 第43回日本発生生物学会大会
  • Place of Presentation: 京都国際会館
  • Year and Date: 2010-06-23
• [Presentation] 三次元タイムラプスによるゼブラフィッシュ三半規管形態形成の解析 (2010)
  • Author(s): 舟橋淳一、川上浩一、仲村春和
  • Organizer: 第115回日本解剖学会
  • Place of Presentation: 盛岡
  • Year and Date: 2010-03-30
• [Presentation] Gene trap revealed a roll of Sox5 in the morphogenesis of the semicircular canal (2009)
  • Author(s): 谷野俊平, 阿部玄武, 川上浩一, 仲村春和, 舟橋淳一
  • Organizer: 第32回日本分子生物学会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-10
• [Book] ラーセン解剖学第4版、第17章視覚器と 聴覚器の発生 (2013)
  • Author(s): 舟橋淳一, 他11名(訳)、仲村春和、大谷浩(監訳)
  • Publisher: 西村書店
• [Remarks]
  • URL: http://www.idac.tohoku.ac.jp/dep/molneuro/
• [Remarks] 研究の概要（Research & News）
  • URL: http://www2.idac.tohoku.ac.jp/dep/molneuro/Dept_Mol_Neurobiol/Research_%26_News/Research_%26_News.html