Mechanism of inner ear and semicircular canalmorphogenesis
| Project/Area Number |
21570216
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 器官形成 / 形態形成 / ニワトリ / ゼブラフィッシュ / Sox5 / ニワトリ胚 / 三次元タイムラプス / トランスジェニック / 三次元タイムラプス解析 / gallery / ポジショナルクローニング |
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| Research Abstract |
Semicircular canals are intriguing model system to study the mechanism of morphogenesis. In this study, two model organisms, zebrafish and chick are used. Utilizing each of its own advantage, cellular and histological analysis was carried out with cutting edge imaging technology. In parallel to these analyses, cloning and functional analysis of the genes related to morphogenesis was done. As a result, it is revealed that Sox5 gene plays a critical roll in semicircular canal morphogenesis.
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Report
(4 results)
Research Products
(14 results)
