| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
Inter-specific hybrids between female of Hd-rR strain of medaka and male Oryzias curvinotus, all XY fish developed into females, but when we used females of HO4C strain of medaka for hybridization, no sex-reversals appeared. Utilizing the polymorphism between HdrR and HO4C, we conducted a linkage analysis to uncover a locus(hml) on the linkage group 17 responsible for the sex reversal. The analysis of the expression of Dmy in the hybrid revealed that the sex-reversal resulted from the decrease of the expression of Dmy during the sex-determining stage, indicating that hml is related to the regulation of Dmy expression. Fine mapping for hml narrowed the region of the locus on the chromosome 17 to 624 KB. We are continuing the study for the identification of hml.
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