Molecular and Cellular mechanisms of germline mother cell regeneration in colonial tunicates
| Project/Area Number |
21570227
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Kochi University |
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Principal Investigator |
KAWAMURA Kazuo 高知大学, 教育研究部・自然科学系, 教授 (30136361)
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| Co-Investigator(Kenkyū-buntansha) |
SUNANAGA Takeshi 高知大学, 教育研究部・自然科学系, 講師 (20448393)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 幹細胞 / 生殖細胞 / 再生 / 無性生殖 / ホヤ / 生殖系列幹細胞 / Vasa / Piwi / Myc / RACK1 / 群体ボヤ / NCR / 生殖系列 / non-coding RNA / キメラ |
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| Research Abstract |
Ascidians are the marine invertebrate that is most closely related to vertebrates. Colonial tunicates propagate by means of both sexual and asexual reproduction, and they can regenerate gonads and germ cells even though gonad components are completely extirpated from the colony. This study has disclosed that Myc/ Piwi-expressing cells are reserved in the hemocoel, and that they respond to BMP to express germline-specific gene Vasa, enabling the regeneration of germline cells and tissues.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Tunicate cytostatic factor TC14 induces the polycomb group gene Eed and histone modification through Ca^<2+> binding and protein dimerization2012
Author(s)
Kawamura, K., Takakura, K., Mori, D., Ikeda, K., Nakamura, A. and Suzuki, T.
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Journal Title
BMC Cell Biol
Volume: 13
Pages: 1-13
Related Report
Peer Reviewed
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[Journal Article] Tunicate cytostatic factor TC14-3 induces a polycomb group gene and histone modification through Ca2+ binding and protein dimerization2012
Author(s)
Kawamura, K., Takakura, K., Mori, D., Ikeda, K., Nakamura, A., Suzuki, T.
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Journal Title
BMC Cell.Biol.
Volume: 13
Issue: 1
Pages: 1-13
DOI
Related Report
Peer Reviewed
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[Journal Article] Germline cell formation and gonad regeneration in solitary and colonial ascidians2011
Author(s)
Kawamura, K., Tiozzo, S., Manni, L., Sunanaga, T., Burighel, P., DeTomaso, A.
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Journal Title
Dev.Dyn.
Volume: 240
Issue: 2
Pages: 299-308
DOI
Related Report
Peer Reviewed
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[Journal Article] Germline cell formation and gonad regeneration in solitary and colonial ascidians.2011
Author(s)
Kawamura, K., Tiozzo, S., Manni, L., Sunanaga, T., Burighel, P., DeTomaso, A.
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Journal Title
Dev.Dyn.
Volume: 240
Pages: 299-308
Related Report
Peer Reviewed
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[Journal Article] Looking for putative phenoloxidases of compound ascidians : haemocyanin-like proteins in Polyandrocarpa misakiensis and Botryllus schlosseri
Author(s)
Ballarin, L., Franchi, N., Schiavon, F., Tosatto, S. C. E, Mi. eti., I. and Kawamura, K.
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Journal Title
Related Report
Peer Reviewed
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