Regulation of angiogenesis by FOXO transcription factors
| Project/Area Number |
21570229
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Kumamoto University |
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Principal Investigator |
OGAWA Minetaro 熊本大学, 発生医学研究所, 教授 (70194454)
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| Co-Investigator(Renkei-kenkyūsha) |
SAKAMOTO Hiroshi 熊本大学, 発生医学研究所, 助教 (00347014)
TAMURA Kiyomi 熊本大学, 発生医学研究所, 助教 (90399973)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 器官形成 / 血管新生 / Foxo1遺伝子 / 血管内皮細胞 / ES細胞 / 血管平滑筋細胞 / 試験管内分化 / 遺伝子発現 / 転写因子 / 微小管ネットワーク |
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| Research Abstract |
The function of Foxo1, a transcription factor which is essential for vascular development, was investigated by using an ES cell culture system. We found that Foxo1 modulates the morphological response of vascular endothelial cells to various angiogenic stimuli and the recruitment of vascular smooth muscle cells to the endothelium, thereby regulating angiogenesis and vascular maturation. A candidate of the Foxo1 target gene which might be involved in the morphological regulation of endothelial cells has been identified by using a functional screening analysis.
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Report
(4 results)
Research Products
(24 results)
