Localization mechanisms of axon guidance molecules and their receptors in C. elegans
| Project/Area Number |
21570230
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
GOSHIMA Yoshio 横浜市立大学, 医学研究科, 教授 (00153750)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 発生遺伝 / 軸索ガイダンス / C.elegans / Netrin / 線虫 / UNC-5 / 局在機構 / 神経 / C. elegans |
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| Research Abstract |
A hypothesis that localizations of axon guidance molecules and their receptors cause variability of neural networks is proposed. However, the molecular mechanisms are largely unknown. By using a model organism C. elegans, we found molecules that regulate localization of an axon guidance molecule UNC-6/Netrin and its receptor UNC-5.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] A seven-transmembrane receptor that mediates avoidance response to dihydrocaffeic acid, a water-soluble repellent in Caenorhabditis elegans2011
Author(s)
Aoki R, Yagami T, Sasakura H, Ogura K, Kajihara Y, Ibi M, Miyamae T, Nakamura F, Asakura T, Kanai Y, Misu Y, Iino Y, Ezcurra M, Schafer WR, Mori I, Goshima Y. J Neurosci.
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Journal Title
J Neurosci
Volume: 31(46)
Pages: 16603-10
Related Report
Peer Reviewed
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