| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Research Abstract |
Maternal factor Mamo is autonomously required in pole cells to produce functional gametes in Drosophila. Mamo protein is predicted to regulate the expression of downstream genes as a chromatin regulator, since Mamo shares sequence homology with chromatin regulators that contain both a BTB/POZ domain and C_2H_2 zinc finger motifs. Using in vitro assays and genetic analysis, we show that Mamo protein directly binds to specific DNA consensus sequences in target downstream genes in order to regulate their expression.
|
