| Project/Area Number |
21570234
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Hyogo University
Kobe University |
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Principal Investigator |
HONDA Hisao 神戸大学, 医学研究科, 学術推進研究員 (10289118)
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| Project Period (FY) |
2009-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | invagination / cell model / vertex dynamics / morphogenesis / 形態形成 / コンピュータシミュレーション / 細胞モデル / 上皮陥入 / 気管 / 神経管 / チューブ / コンピュータ・シミュレーション / 3次元細胞モデル / 細胞・組織 / 発生・分化 |
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| Research Abstract |
The process of morphogenesis of multi-cellular organisms can be expressed as "Genes-Cells-Shape". To elucidate the detailed process based on actual substances, I studied a latter half of the process from Cells to Shape using a mathematical cell model. A computer simulation was performed of an epithelial invagination of the trachea formation of Drosophila, referring to actual observations. The simulation of the invagination was succeeded based several assumptions of cell behaviors. However, one of the assumptions, cell migration toward the embryo inside is arguable. On the other hand, I studied a polygonal cellular pattern of invagination in the neural tube formation. Here, anisotropic localization of the planar cell polarity gene, celsr was elucidated to cause anisotropic localization of myosin molecules that generates morphogenetic force. Then, one of the routes from genes to shape was established.
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