A study of the intrinsically photosensitive retinal ganglion cells : a functional role on non-image and image forming pathways

• Project/Area Number: 21570247
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied anthropology
• Research Institution: Kagoshima University
• Principal Investigator: TSUJIMURA Seiichi 鹿児島大学, 大学院・理工学研究科, 准教授 (10381154)
• Co-Investigator(Kenkyū-buntansha): NURUKI Atsuo 鹿児島大学, 大学院・理工学研究科, 助教 (50336319) ; YUNOKUCHI Kazutomo 鹿児島大学, 大学院・理工学研究科, 教授 (10094187) ; MORITA Takeshi 福岡女子大学, 人間環境学部, 教授 (20326474)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: メラノプシン神経節細胞 / 瞳孔反応潜時 / ERG / 瞳孔反応 / 多原色光源刺激装置

Research Abstract

We have investigated a functional role of the intrinsically photosensitive retinal ganglion cells(ipRGCs) to the non-image forming and image-forming pathways. It was found that the ipRGCs contribute to the steady-state pupillary control mechanism. The manuscript for a study of the contribution on the image-forming pathway is in press.

Research Products

• [Journal Article] Melanopsin-based brightness discrimination in mice and humans (2012)
  • Author(s): T. M. Brown, S. Tsujimura, A. E. Allen1, J. Wynne, R. Bedford, G. Vickery, A. Vugler, R. J. Lucas
  • Journal Title: Current Biology Volume: (in press) Issue: 12 Pages: 1134-1141
  • DOI: 10.1016/j.cub.2012.04.039
  • Peer Reviewed
• [Journal Article] Delayed response of human melanopsin retinal ganglion cells on the pupillary light reflex (2011)
  • Author(s): S. Tsujimura and Y. Tokuda
  • Journal Title: Ophthalmic and Physiological Optics Volume: 31 Issue: 5 Pages: 469-79
  • DOI: 10.1111/j.1475-1313.2011.00846.x
  • Peer Reviewed
• [Journal Article] The ERG responses to light stimuli of melanopsin-expressing retinal ganglion cells that are independent of rods and cones (2010)
  • Author(s): Y. Fukuda, S. Tsujimura, S. Higuchi, A. Yasukouchi and T. Morita
  • Journal Title: Neurosci Letter Volume: 479 Issue: 3 Pages: 282-286
  • DOI: 10.1016/j.neulet.2010.05.080
  • Peer Reviewed
• [Journal Article] Contribution of human melanopsin retinal ganglion cells to steady-state pupil responses (2010)
  • Author(s): S. Tsujimura, K. Ukai, D. Ohama, A. Nuruki & K. Yunokuchi
  • Journal Title: Proc. R. Soc. Lond. B Volume: 277(1693) Issue: 1693 Pages: 2485-2492
  • DOI: 10.1098/rspb.2010.0330
  • NAID: 120005303688
  • Peer Reviewed
• [Journal Article] The ERG responses to light stimuli of melanopsin-expressing retinal ganglion cells that are independent of rods and cones. (2010)
  • Author(s): Y.Fukuda, 他4名
  • Journal Title: Neurosci Letter Volume: 479 Pages: 282-286
  • Peer Reviewed
• [Journal Article] Contribution of human melanopsin retinal ganglion cells to steady-state pupil responses (2010)
  • Author(s): S.Tsujimura, K.Ukai, D.Ohama, A.Nuruki, K.Yunokuchi
  • Journal Title: Proc.R.Soc.Lond.B doi:10.1098/rspb.2010.0330
  • NAID: 120005303688
  • Peer Reviewed
• [Presentation] Rod and Cone pathways converging on the central targets of melanopsin ganglion cells (2012)
  • Author(s): T. M. Brown, A. E. Allen, S. Tsujimura, R. J. Lucas
  • Organizer: Society for neuroscience
  • Place of Presentation: Washington, DC, USA
• [Presentation] Rod and Cone pathways converging on the central targets of melanopsin ganglion cells (2011)
  • Author(s): T.M.Brown, A.E.Allen, S.Tsujimura, R.J.Lucas
  • Organizer: Society for neuroscience
  • Place of Presentation: San Diego, USA
  • Year and Date: 2011-11-12
• [Presentation] Diurnal variation in responses of melanopsin-expressing retinal ganglion cells to light in the human retina (2011)
  • Author(s): Y. Fukuda, S. Tsujimura, S. Higuchi, A. Yasukouchi, T. Morita
  • Organizer: WorldSleep2011
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2011-10-19
• [Presentation] Temporal properties of human melanopsin-containing retinal ganglion cells on the pupillary light reflex (2011)
  • Author(s): S. Tsujimura
  • Organizer: The 29th Pupil Colloquium
  • Place of Presentation: Tuebingen, Germany
  • Year and Date: 2011-09-27
• [Presentation] The contribution of the rod/melanopsin driven ganglion cells to the dynamic pupil light reflex response (2011)
  • Author(s): J. L. Barbur, W. Bi, S. Tsujimura, G. T. Plant
  • Organizer: The 29th Pupil Colloquium
  • Place of Presentation: Tuebingen, Germany
  • Year and Date: 2011-09-27
• [Presentation] The contribution of the rod/melanopsin driven ganglion cells to the dynamic pupil light reflex response (2011)
  • Author(s): J.L.Barbur, W.Bi, S.Tsujimura, G.T.Plant
  • Organizer: The 29^<th> Pupil Colloquium
  • Place of Presentation: Tuebingen, Germany
  • Year and Date: 2011-09-25
• [Presentation] Temporal properties of human melanopsin-containing retinal ganglion cells on the pupillary light reflex (2011)
  • Author(s): S.Tsujimura
  • Organizer: The 29^<th> Pupil Colloquium
  • Place of Presentation: Tuebingen, Germany
  • Year and Date: 2011-09-25
• [Presentation] Delayed response of human melanopsin retinal ganglion cells on the pupillary light reflex (2011)
  • Author(s): S. Tsujimura
  • Organizer: Prof. Bernard Gilmartin Festschrift
  • Place of Presentation: Birmingham, UK
  • Year and Date: 2011-09-14
• [Presentation] Delayed response of human melanopsin retinal ganglion cells on the pupillary light reflex (2011)
  • Author(s): S.Tsujimura
  • Organizer: Prof.Bernard Gilmartin Festschrift
  • Place of Presentation: Birmingham, UK(招待講演)
  • Year and Date: 2011-09-14
• [Presentation] ERG responses of melanopsin-expressing retinal ganglion cells in the human retina (2011)
  • Author(s): Y. Fukuda, S. Tsujimura, S. Higuchi, A. Yasukouchi, T. Morita
  • Organizer: European Biological Rhythms Society
  • Place of Presentation: Oxford, UK
  • Year and Date: 2011-08-26
• [Presentation] Circadian Rhythm of Melanopsin-expressing Retinal Ganglion Cells in the Human Retina (2011)
  • Author(s): Y. Fukuda, S. Tsujimura, S. Higuchi, A. Yasukouchi, T. Morita
  • Organizer: Society for Light Treatment and Biological Rhythms(SLTBR) The 23rd Annual meeting
  • Place of Presentation: Montreal, Canada
  • Year and Date: 2011-07-11
• [Presentation] Circadian Rhythm of Melanopsin-expressing Retinal Ganglion Cells in the Human Retina (2011)
  • Author(s): Y.Fukuda, S.Tsujimura, S.Higuchi, A.Yasukouchi, T.Morita
  • Organizer: Society for Light Treatment and Biological Rhythms (SLTBR) The 23rd Annual meeting
  • Place of Presentation: Montreal, Canada
  • Year and Date: 2011-07-10
• [Presentation] Contribution of human melanopsin ganglion cells to the nonimage forming pathway (2010)
  • Author(s): S Tsujimura
  • Organizer: International Association of Physiological Anthropology(ICPA)
  • Place of Presentation: Fremantle, Australia
  • Year and Date: 2010-09-11
• [Presentation] The response of melanopsin-expressing retinal ganglion cells to light stimuli with frequency changes (2010)
  • Author(s): Y Fukuda, S Tsujimura, S Higuchi, A Yasukouchi, T Morita
  • Organizer: International Association of Physiological Anthropology(ICPA)
  • Place of Presentation: Fremantle, Australia
  • Year and Date: 2010-09-11
• [Presentation] Contribution of human melanopsin ganglion cells to the nonimage forming pathway (2010)
  • Author(s): Tsujimura S, 他4名
  • Organizer: 10th International Congress of Physiological Anthropology
  • Place of Presentation: Perth, Australia
  • Year and Date: 2010-09-11
• [Presentation] The response of melanopsin-expressing retinal ganglion cells to light stimuli with frequency changes (2010)
  • Author(s): Fukuda Y, 他4名
  • Organizer: 10th International Congress of Physiological Anthropology
  • Place of Presentation: Perth, Australia
  • Year and Date: 2010-09-11
• [Presentation] THE ERG RESPONSES TO LIGHT STIMULUS LEVELS OF MELANOPSIN-EXPRESSING RETINAL GANGLION CELLS WITH THE RECEPTOR-SILENT SUBSTITUTION TECHNIQUE (2010)
  • Author(s): Y. Fukuda, S. Tsujimura, S. Higuchi, A. Yasukouchi, T. Morita
  • Organizer: 2010 Society for Light Treatment and Biological Rhythms
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2010-07-01
• [Presentation] Contribution of melanopsin-expressing retinal ganglion cells to pupillary control pathway studied with a receptor-silent substitution technique (2009)
  • Author(s): S. Tsujimura, K. Ukai, A. Nuruki, K. Yunokuchi
  • Organizer: 20th Symposium of the International Colour Vision Society Braga
  • Place of Presentation: Portugal
  • Year and Date: 2009-07-26
• [Remarks]
• [Remarks]
  • URL: http://www.ibe.kagoshima-u.ac.jp/~t_lab/Publications.htm