Functional analysis of GGDEF/EAL proteins that control the stability of small RNA
| Project/Area Number |
21580088
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Research Collaborator |
TONY Romeo フロリダ大学, 微生物・細胞科学, 教授
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 大腸菌 / バイオフィルム / GGDEFドメイン / EALドメイン / c-di-GMP / Csrシステム / small RNA / c-fi-GMP |
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| Research Abstract |
To elucidate the mechanism of bacterial biofilm formation control, we analyzed the function of the GGDEF/EAL proteins in bacteria. GGDEF/EAL protein CsrD was not involved in c-di-GMP metabolism and altered the activity in each growth phase and controlled biofilm formation by regulating the stability of small RNA. On the other hand, YliF(GGDEF protein) and YliE(EAL protein) controlled biofilm formation by regulating the synthesis and degradation of c-di-GMP.
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Report
(4 results)
Research Products
(14 results)
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[Presentation] 大腸菌CsrB RNAの分解機構2010
Author(s)
鈴木一史,伊藤学,岡山明裕,水野孝彦,渡邉剛志, Tony Romeo
Organizer
日本農芸化学会2010年度大会
Place of Presentation
名城大学(名古屋市)
Year and Date
2010-03-28
Related Report
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