Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Research Abstract |
Glycosylphosphatidylinositol(GPI) is a complex glycolipid that anchors proteins to the plasma membrane. In this study, using a deletion mutant of ARV1 gene that encodes a putative flippase required for the transport of a GPI intermediate to the ER lumen and other mutants defective in GPI synthesis, we found that GPI synthesis regulates aging and cell death in yeast, and the cell death is largely concerned with structure and function of telomere.
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