Analysis of the physiological significance of GPI flippase and synthesis

Research Project

Project/Area Number	21580094
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Applied microbiology
Research Institution	Hiroshima University
Principal Investigator	FUNATO Kouichi 広島大学, 大学院・生物圏科学研究科, 准教授 (30379854)
Project Period (FY)	2009 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000) Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	微生物機能 / 糖脂質 / 生体膜 / 細胞機能制御 / 脂質 / 糖 / 微生物
Research Abstract	Glycosylphosphatidylinositol(GPI) is a complex glycolipid that anchors proteins to the plasma membrane. In this study, using a deletion mutant of ARV1 gene that encodes a putative flippase required for the transport of a GPI intermediate to the ER lumen and other mutants defective in GPI synthesis, we found that GPI synthesis regulates aging and cell death in yeast, and the cell death is largely concerned with structure and function of telomere.

Report

(4 results)