Connection between respiration and secondary metabolite formation in Streptomyces : An unknown role of the terminal respiratory enzymes
| Project/Area Number |
21580103
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | Nihon University |
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Principal Investigator |
UEDA Kenji 日本大学, 生物資源科学部, 准教授 (00277401)
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| Co-Investigator(Kenkyū-buntansha) |
TAKANO Hideaki 日本大学, 生物資源科学部, 助教 (50385994)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | Streptomyces / copper / cytochrome oxidase / Sco1 / antibiotics / cell differentiation / regulation / lysyloxidase / Scol / respiration / conservon |
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| Research Abstract |
We studied the connection between energy metabolism and secondary metabolism in Streptomyces, the bacteria renowned for the ability to produce useful biologically active substances such as antibiotics. By focusing on the role of enzymes involved in respiration, i. e. the important process at the terminus of energy metabolic flow, we revealed that the major respiratory enzyme termed cytochrome oxidase plays an important role in the signaling for the initiation of antibiotic production. The findings will be fundamental to the development of effective fermentation process for useful substances.
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Report
(4 results)
Research Products
(15 results)
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[Presentation] 放線菌細胞の凝集と沈降2010
Author(s)
藤本正浩、山田晃朗、高野英晃、上田賢志
Organizer
2010年度日本放線菌学会大会
Place of Presentation
タワーホール船堀(江戸川区船堀)
Year and Date
2010-09-03
Related Report
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