I dentification and characterization of the genes involved in generation or quenching of reactive oxygen species
Project/Area Number |
21580115
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Applied biochemistry
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Research Institution | Yokohama City University |
Principal Investigator |
FUJII Michihiko 横浜市立大学, 生命ナノシステム科学研究科, 准教授 (80285155)
|
Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 代謝生理 / 活性酸素 |
Research Abstract |
Oxygen is essential for aerobic organisms, but generates reactive oxygen species(ROS), which can cause cellular dysfunction that would accelerate aging and diseases. We have studied the genes involved in the generation or the quenching of ROS with use of the nematode Caenorhabditis elegans as a model organism. In this study, we analyzed the expression patterns of OXY-5 and RAD-8 in C. elegans, and identified genes that, when down regulated, cause an increased sensitivity to ROS by systematic screening of the genes located on linkage group I.
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Report
(4 results)
Research Products
(43 results)
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[Journal Article] Sublethal Doses of Surfactants Induce Premature Senescence in Normal Human Skin Cells2011
Author(s)
Y. Yamakami, K. Miki, M. Endoh, R. Yonekura, R. Ukekawa, Y. Kobayashi, M. Fujii, D. Ayusawa
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Journal Title
Bioscience, Biotechnology, and Biochemistry
Volume: 75
Issue: 7
Pages: 1395-1398
DOI
NAID
ISSN
0916-8451, 1347-6947
Related Report
Peer Reviewed
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[Journal Article] 5-bromodeoxyuridine induces transcription of repressed genes with disruption of nucleosome positioning2010
Author(s)
Milki, K., Shimizu, M., Fujii, M., Takayama, S., Hossain, M.N., Ayusawa, D.
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Journal Title
Febs J.
Volume: 277
Pages: 4539-48
Related Report
Peer Reviewed
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[Journal Article] (2009)Coordinate expression of the human pregnancy-specific glycoprotein gene family during induced and replicative senescence2009
Author(s)
Endoh, M., Kobayashi, Y., Yamakami, Y, Yonekura, R., Fujii, M., Ayusawa, D.
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Journal Title
Biogerontology 10
Pages: 213-221
Related Report
Peer Reviewed
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