| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Research Abstract |
We have reported previously that Fbs1 and Fbs2 are glycoprotein-specific F-box proteins, which are identified as the endoplasmic reticulum-associated degradation(ERAD)-linked ubiquitin ligase component. Here we report that Fbxo44b, which does not have sugar-binding activity, is involved in ubiquitylation of glycoproteins under the ERAD pathway. In addition, we analyzed the third F-box protein recognizing N-glycoproteins, Fbs3.Fbs3 can interact with glycoproteins modified with not only high-mannose but also complex-type glycans, suggesting that participates in unknown function of glycoproteins endocytosed from the cell surface but not through the ERAD pathway.
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