| Project/Area Number |
21580129
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | Kitasato University |
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Principal Investigator |
SHIOMI Kazuro 北里大学, 大学院・感染制御科学府, 教授 (40235502)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAHASHI Yoko 北里大学, 大学院・感染制御科学府, 教授 (80197186)
MASUMA Rokuro 北里大学, 大学院・感染制御科学府, 准教授 (90219353)
HANAKI Hideaki 北里大学, 北里生命科学研究所, 室長 (60286747)
IWATSUKI Masato 北里大学, 北里生命科学研究所, 上級研究員 (70353464)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 薬剤耐性克服 / MRSA / 抗生物質 / アルベカシン / 天然物化学 / アルベカシン耐性 / 微生物代謝産物 / アミノグリコシド抗生物質 |
|---|
| Research Abstract |
Arbekacin is used for MRSA, multi-drug resistant bacteria. However, arbekacin resistant MRSA emerged. It becomes resistant by possessing a bifunctional enzyme that modifies arbekacin by phosphorylation or acetylation. We found aranorosin and biverlactones as circumventors of arbekacin resistance in MRSA. Arbekacin with a combination of those compounds inhibits the growth of arbekacin resistant MRSA.
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