Investigation of the mechanism of neuroprotection by neoechinulin A
| Project/Area Number |
21580131
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ARAI Takao 東京理科大学, 理工学部・応用生物科学科, 教授 (60107422)
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| Co-Investigator(Renkei-kenkyūsha) |
KURAMOCHI Kouji 京都府立大学, 農学部, 准教授 (90408708)
KOBAYASHI Susumu 東京理科大学, 薬学部, 教授 (70101102)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 薬理学 / 痴呆 / 老化 / 抗生物質 / 神経科学 / ネオエキヌリンA / アルカロイド / 一酸化窒素 / ネオエキヌリン / 酸化ストレス / 変性神経疾患 / 活性酸素 / 活性窒素 |
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| Research Abstract |
Cytotoxicity by reactive nitrogen species is suggested responsible for various neurodegenerative diseases. Treatment with neoechinulin A renders cells resistant to insults by reactive nitrogen species but the mechanism remained unclear. In this study, we clarified a novel mechanism underlying the cytoprotective action of neoechinulin A treatment ; neoechinulin A engenders an increase in cellular reserve capacity for NAD(P) H generation. We also established for the first time a cellular model of Alzheimer's disease, with which the effectiveness of neoechinulin A would be assessed.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Synthesis and Neuroprotective Action of Optically Pure Neoechinulin A and Its Analogs2010
Author(s)
Aoki T, Ohnishi K, Kimoto M, Fujieda S, Kuramochi K, Takeuchi T, Nakazaki A, Watanabe N, Sugawara F, Arai T, Kobayashi S
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Journal Title
Pharmaceuticals
Volume: 3
Pages: 1063-1069
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[Presentation] Neoechinulin A confers resistance against nitrosative stress despite inducing a significant depletion of cellular GSH2011
Author(s)
Watanabe N, Akashi S, Nakagawa T, Okada T, Takeuchi T, Kuramochi K, Sugawara F, Kobayashi S, Arai T
Organizer
18th Annual Meeting of the Society for Free Radical Biology and Medicine
Place of Presentation
Atlanta, GA, USA
Year and Date
2011-12-18
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[Presentation] Neoechinulin A confers cytoprotection against nitrosative stresses in PC12 cells while paradoxically decreasing GSH contents2011
Author(s)
Nakagawa T, Akashi S, Okada T, Konishi K, Ogura Y, Kuramochi K, Kobayashi S, Sugawara F, Takeuchi T, Watanabe N, Arai T
Organizer
5th Biannual Meeting of the Society for Free Radical Research-Asia
Place of Presentation
Kagoshima, Japan
Year and Date
2011-09-01
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