| Project/Area Number |
21580131
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ARAI Takao 東京理科大学, 理工学部・応用生物科学科, 教授 (60107422)
|
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| Co-Investigator(Renkei-kenkyūsha) |
KURAMOCHI Kouji 京都府立大学, 農学部, 准教授 (90408708)
KOBAYASHI Susumu 東京理科大学, 薬学部, 教授 (70101102)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 薬理学 / 痴呆 / 老化 / 抗生物質 / 神経科学 / ネオエキヌリンA / アルカロイド / 一酸化窒素 / ネオエキヌリン / 酸化ストレス / 変性神経疾患 / 活性酸素 / 活性窒素 |
|---|
| Research Abstract |
Cytotoxicity by reactive nitrogen species is suggested responsible for various neurodegenerative diseases. Treatment with neoechinulin A renders cells resistant to insults by reactive nitrogen species but the mechanism remained unclear. In this study, we clarified a novel mechanism underlying the cytoprotective action of neoechinulin A treatment ; neoechinulin A engenders an increase in cellular reserve capacity for NAD(P) H generation. We also established for the first time a cellular model of Alzheimer's disease, with which the effectiveness of neoechinulin A would be assessed.
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