RESEARCH FOR THE MECHANISM OF MUCIN SECRETORY EFFECTS BY DIETARY FIBER AND ITS PHYSIOLOGICAL SIGNIFICANCE

• Project/Area Number: 21580136
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Food science
• Research Institution: Shizuoka University
• Principal Investigator: MORITA Tatsuya 静岡大学, 農学部, 教授 (90332692)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 栄養化学 / 食物繊維 / ムチン / 粘度 / 嵩 / 杯細胞 / アレルギー

Research Abstract

Mucin is a key component of the gut barrier that prevents potential pathogens and antigens from gaining access to the underlying epithelium. The study examined physicochemical properties of dietary fiber(DF) that determine small intestinal mucin secretion. It turned out that small intestinal mucins were secreted in proportion to the settling volume in water(bulk-forming properties) of water-insoluble DF or the viscosity of water-soluble DF. The stimulatory effects of both soluble and insoluble DF on mucin secretion appear to be linked to the subsequent increase in goblet cell number.

Research Products

• [Journal Article] Degree of polymerization of inulin-type fructans differentially affects number of lactic acid bacteria, intestinal immune functions, and immunoglobulin A secretion in the rat cecum (2011)
  • Author(s): Ito, H., Takemura, N., Sonoyama, K., Kawagishi, H., Topping, D.L., Conlon, M.A., Morita, T
  • Journal Title: J Agric Food Chem Volume: 59 Pages: 5771-5778
  • Peer Reviewed
• [Journal Article] Ameliorating Effects of Short-Chain Inulin-Like Fructans on the Healing Stage of Trinitrobenzene Sulfonic Acid-Induced Colitis in Rats (2011)
  • Author(s): Shingo Hino, Hiroyuki Ito, Hiroyuki Bito, Hirokazu Kawagishi, Tatsuya Morita
  • Journal Title: Bioscience, Biotechnology, and Biochemistry Volume: 75 Issue: 11 Pages: 2169-2174
  • DOI: 10.1271/bbb.110460
  • NAID: 10030396728
  • ISSN: 0916-8451, 1347-6947
  • Peer Reviewed
• [Journal Article] Degree of Polymerization of Inulin-Type Fructans Differentially Affects Number of Lactic Acid Bacteria, Intestinal Immune Functions, and Immunoglobulin A Secretion in the Rat Cecum (2011)
  • Author(s): Hiroyuki Ito, Naoki Takemura, Kei Sonoyama, Hirokazu Kawagishi, David Topping, Michael Conlon, Tatsuya Morita
  • Journal Title: J Agricultural Food Chemistry Volume: 59 Issue: 10 Pages: 5771-5778
  • DOI: 10.1021/jf200859z
  • Peer Reviewed
• [Journal Article] Comparison of gut microbiota and allergic reactions in BALB/c mice fed different cultivars of rice (2010)
  • Author(s): Sonoyama, K., Ogasawara, T., Goto, H., Yoshida, T., Takemura, N., Fujiwara, R., Watanabe, J., Ito, H., Morita, T, Tokunaga, Y., Yanagihara, T.
  • Journal Title: Brit J Nutr Volume: 103 Pages: 218-226
  • NAID: 120002693630
  • Peer Reviewed
• [Journal Article] トリニトロヘンセンスルホン酸を用いた再発大腸炎モテルの免疫学的解析 (2010)
  • Author(s): 伊藤弘幸、加藤俊彦、河田伊織、尾藤寛之、河岸洋和、桐山修八、森田達也
  • Journal Title: 日本食物繊維学会誌 Volume: 14 Pages: 33-44
  • Peer Reviewed
• [Journal Article] Inulin prolongs survival of intragastrically administered Lactobacillus plantarum No. 14 in the gut of mice fed a high-fat diet (2010)
  • Author(s): Takemura, N., Hagio, M., Ishizuka, S., Ito, H., Morita, T, Sonoyama, K.
  • Journal Title: J Nutr Volume: 141 Pages: 1963-1969
  • Peer Reviewed
• [Journal Article] Effects of fructo-oligosaccharide on DSS-induced colitis differ in mice fed non-purified and purified diets (2010)
  • Author(s): Goto, H., Takemura, N., Ogasawara, T., Sasajima, N., Watanabe, J., Ito, H., Morita, T, Sonoyama, K.
  • Journal Title: J Nutr Volume: 140 Pages: 2121-2127
  • Peer Reviewed
• [Journal Article] トリニトロベンゼンスルホン酸を用いた再発大腸炎モデルの免疫学的解析 (2010)
  • Author(s): 伊藤弘幸
  • Journal Title: 日本食物繊維学会誌 Volume: 14 Pages: 33-44
  • Peer Reviewed
• [Journal Article] Toxic isolectins from the mushroom Boletus venenatus (2010)
  • Author(s): Masashi Horibe
  • Journal Title: Phytochemistry Volume: 71 Pages: 618-657
  • Peer Reviewed
• [Journal Article] Effects of Fructo-Oligosaccharide on DSS-Induced Colitis Differ in Mice Fed Nonpurified and Purified Diets (2010)
  • Author(s): Haruka Goto
  • Journal Title: The Journal of Nutrition Volume: 140 Pages: 2121-2127
  • Peer Reviewed
• [Journal Article] Short-chain inulin-like fructansreduce endotoxin and bacterial translocations and attenuate the development of TNBS-induced colitis in rats (2009)
  • Author(s): Ito, H., Tanabe, H., Kawagishi, H., Wada, T., Sugiyama, K., Kiriyama, S., Morita, T
  • Journal Title: Dig Dis Sci Volume: 54 Pages: 2100-2108
  • Peer Reviewed
• [Journal Article] Soluble fiber viscosity affects both goblet cell number and small intestine mucin secretion in rats (2009)
  • Author(s): Ito, H., Eiko, A., Sugiyama, K., Sonoyama, K., Kiriyam, S., Morita, T
  • Journal Title: J Nutr Volume: 139 Pages: 1640-1647
  • Peer Reviewed
• [Journal Article] Response of Gut Microbiota to Fasting and Hibernation in Syrian Hamsters (2009)
  • Author(s): Sonoyama, K., Fujiwara, R., Takemura, N., Ogasawaram T., Watanabe, J., Ito, H., Morita, T
  • Journal Title: J Applied and Environmental Microbiology Volume: 75(20) Pages: 6451-6456
  • NAID: 120002045458
  • Peer Reviewed
• [Journal Article] ルミナコイトの嵩形成能および発酵性かラット小腸および盲腸でのムチン分泌に及ほす影響 (2009)
  • Author(s): 伊藤弘幸、加藤俊彦、河田伊織、森田達也、桐山修八
  • Journal Title: 日本食物繊維学会誌 Volume: 13 Pages: 107-117
  • Peer Reviewed
• [Journal Article] Short-chain inulin-like fructans reduce endotoxin and bacterial translocations and attenuate the development of TNBS-induced colitis in rats (2009)
  • Author(s): 伊藤弘幸
  • Journal Title: Digestive Diseases and Sciences 54 Pages: 2100-2108
  • Peer Reviewed
• [Journal Article] Soluble fiber viscosity affects both goblet cell number and small intestine mucin secretion in rats (2009)
  • Author(s): 伊藤弘幸
  • Journal Title: Journal of Nutrition 139 Pages: 1640-1647
  • Peer Reviewed
• [Journal Article] ルミナコイドの嵩形成能および発酵性がラット小腸および盲腸でのムチン分泌に及ぼす影響 (2009)
  • Author(s): 伊藤弘幸
  • Journal Title: 日本食物繊維学会誌 13 Pages: 107-117
  • Peer Reviewed
• [Journal Article] Ameliorating effects of short-chain inulin-like fructans on the healing stage of trinitrobenzene sulfonic acid-induced colitis in rats
  • Author(s): Hino, S., Ito, H., Bito, H., Kawagishi, H., Morita, T.
  • Journal Title: Biosci Biotechnol Biochem Volume: (in press)
  • NAID: 10030396728
  • Peer Reviewed
• [Presentation] ペクチンの化学情報は,杯細胞からのムチン分泌を促進すると同時に,腸間膜リンパ節のTh-1/Th-2バランスを修飾する (2011)
  • Author(s): 尾藤寛之, 日野真吾, 園山慶, 森田達也
  • Organizer: 第16回日本食物繊維学会学術集会
  • Place of Presentation: 国立栄養科学研究所,(東京)
  • Year and Date: 2011-11-23
• [Presentation] 除菌ラットにおける食物繊維摂取時の杯細胞数増加作用;エンドトキシン関与の解析 (2011)
  • Author(s): 日野真吾, 最田裕善, 森田達也
  • Organizer: 第16回日本食物繊維学会学術集会
  • Place of Presentation: 国立栄養科学研究所,(東京)
  • Year and Date: 2011-11-23
• [Presentation] 食物繊維による杯細胞増加作用は中心静脈栄養,経管(胃瘻)栄養時にも観察される (2011)
  • Author(s): 伊藤文乃, 土井彩友美, 河田伊織, 日野真吾, 森田達也
  • Organizer: 第16回日本食物繊維学会学術集会
  • Place of Presentation: 国立栄養科学研究所,(東京)
  • Year and Date: 2011-11-23
• [Presentation] Novel nutritional aspects of oligosaccharides (2011)
  • Author(s): Tatsuya Morita
  • Organizer: CSIRO Conference, Dietary Fibre & Health
  • Place of Presentation: Adelaide, (Australia)(招待講演)
  • Year and Date: 2011-05-17
• [Presentation] キトサン摂取は杯細胞数の変動とは無関係に小腸ムチン分泌量を増加させる (2011)
  • Author(s): 半田圭, 尾藤寛之, 伊藤弘幸, 日野真吾, 森田達也
  • Organizer: 65回日本栄養・食糧学会大会
  • Place of Presentation: お茶の水女子大,(東京)
  • Year and Date: 2011-05-15
• [Presentation] 高体積・高粘度食物繊維の摂取による小腸杯細胞応答は期間非依存的なシアロムチン分泌型の増加による (2011)
  • Author(s): 河田伊織, 福田智紀, 伊藤弘幸, 日野真吾, 森田達也
  • Organizer: 65回日本栄養・食糧学会大会
  • Place of Presentation: お茶の水女子大,(東京)
  • Year and Date: 2011-05-15
• [Presentation] What happens in gut fermentation, and the role of short-chain fatty acids in gut health (2011)
  • Author(s): Tatsuya Morita
  • Organizer: Kellogg Advisory board meeting
  • Place of Presentation: Leuven, (Belgium)(招待講演)
  • Year and Date: 2011-04-09
• [Presentation] Physicochemical Properties of Luminacoids that Determine Small Intestine Mucin Secretion (2010)
  • Author(s): Tatsuya Morita
  • Organizer: 日本食品免疫学会(シンポジウム)
  • Place of Presentation: 東京、東京大学安田講堂
  • Year and Date: 2010-06-02
• [Presentation] ルミナコイド摂取による小腸ムチン分泌促進機構 (2009)
  • Author(s): 森田達也
  • Organizer: 日本栄養食糧学会 (シンポジウム)
  • Place of Presentation: 長崎、長崎シーボルト大学
  • Year and Date: 2009-05-22
• [Book] 消化管の栄養・生理と腸内細菌 (2011)
  • Author(s): 森田達也
  • Total Pages: 7
  • Publisher: 日本メディア社
• [Book] ルミナコイド研究のフロンティア (2010)
  • Author(s): 森田達也
  • Publisher: 建白社