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Studies on the regulation of homocysteine metabolism by dietary factors

Research Project

Project/Area Number 21580137
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Food science
Research InstitutionShizuoka University

Principal Investigator

SUGIYAMA Kimio  静岡大学, 農学部, 教授 (00126781)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsホモシステイン / 含硫アミノ酸 / 動脈硬化 / 食餌因子 / betaine-homocysteine methyltransferase / methionine synthase / 葉酸 / ベタイン / 栄養学 / コリン / 動脈効果
Research Abstract

Plasma homocysteine(Hcy) is an independent risk factor for cardiovascular disease. This study was conducted to clarify the mechanism by which several dietary factors, such as protein, methionine, choline, folate, affect Hcy metabolism using rats as experimental animals. The results of the present study clearly showed that Hcy metabolism was largely influenced by several dietary factors through different mechanisms.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (28 results)

All 2012 2011 2010 2009

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (19 results)

  • [Journal Article] Effect of dietary supplementation with folate on choline deficiency-induced hyper homocysteinemia inrats2012

    • Author(s)
      Liu Y, Liu Y, Morita T, Mori M, and Sugiyama K
    • Journal Title

      J. Nutr Sci. Vitaminol.

      Volume: 58 Pages: 20-28

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of betaine supplementation andcholine deficiency on folate deficiency-induced hyper homocysteinemia in rats2012

    • Author(s)
      Liu Y, Liu Y, Morita T, and Sugiyama K
    • Journal Title

      J. Nutr. Sci. Vitaminol.

      Volume: 58 Pages: 69-77

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Factors contributing to the resistivity of a higher casein diet against choline deficiency-induced hyper homocyste inemia in rats2012

    • Author(s)
      Liu Y, Liu Y, Morita T, Mori M, and Sugiyama K
    • Journal Title

      J. Nutr. Sci. Vitaminol.

      Volume: 58 Pages: 78-87

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of dietary supplementation with folate on choline deficiency-induced hyperhomocysteinemia in rats2012

    • Author(s)
      Y.Liu, Y.Liu, T.Morita, M.Mori, K.Sugiyama
    • Journal Title

      J.Nutr.Sci.Vitaminol.

      Volume: 58 Pages: 20-28

    • NAID

      130002103059

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of betaine supplementation and choline deficiency on folate Deficiency-induced hyperhomocysteinemia in rats2012

    • Author(s)
      Y.Liu, Y.Liu, T.Morita, K.Sugiyama
    • Journal Title

      J.Nutr.Sci.Vitaminol.

      Volume: 58 Pages: 69-77

    • NAID

      130002103034

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Factors contributing to the resistivity of a higher casein diet against choline deficiency-induced hyperhomocysteinemia in rats2012

    • Author(s)
      Y.Liu, Y.Liu, T.Morita, M.Mori, K.Sugiyama
    • Journal Title

      J.Nutr.Sci.Vitaminol.

      Volume: 58 Pages: 78-87

    • NAID

      130002103035

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Motioning and serine synergistically suppress hyper homocysteinemia induced by choline deficiency, but not by guanidino aceticacid, in rats fed a low casein diet2011

    • Author(s)
      Liu Y, Liu Y, Morita T, and Sugiyama K
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: 75 Pages: 2333-2339

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Methionine and serine synergistically suppress hyperhomocysteinemia induced by choline deficiency, but not by guanidinoacetic acid, in rats fed a low casein diet2011

    • Author(s)
      Y.Liu, Y.Liu, T.Morita, K.Sugiyama
    • Journal Title

      Biosci.Biotechnol.Biochem.

      Volume: 75 Pages: 2333-2339

    • NAID

      10030397601

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High casein diet decreases plasma homocysteine concentration in rats2009

    • Author(s)
      K.Ohuichi, Y.Matsumoto, T.Morita, K.Sugiyama
    • Journal Title

      Journal of Nutritional Science and Vitaminology 55

      Pages: 22-30

    • NAID

      110007110612

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] BHMT活性に影響を及ぼす食餌因子とホモシステイン代謝2011

    • Author(s)
      劉軼群, 劉穎, 土屋諒, 杉山公男
    • Organizer
      日本栄養・食糧学会
    • Place of Presentation
      お茶の水女子大学(東京都)
    • Year and Date
      2011-05-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] コリン欠乏による高ホモシステイン血章に及ぼす葉酸の効果2011

    • Author(s)
      劉穎, 劉軼群, ドヴァンタイ, 杉山公男
    • Organizer
      日本栄養・食糧学会
    • Place of Presentation
      お茶の水女子大学(東京都)
    • Year and Date
      2011-05-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 低メチオニン食へのシステイン添加による脂肪肝の生成について2011

    • Author(s)
      土屋諒, 劉軼群, 石神有介, 杉山公男
    • Organizer
      日本栄養・食糧学会
    • Place of Presentation
      お茶の水女子大学(東京都)
    • Year and Date
      2011-05-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] 高タンパク質食が血漿ホモシステイン濃度を上昇させない機構について2010

    • Author(s)
      呉育如、鈴木朋恵、大久保昭宏、杉山公男
    • Organizer
      日本栄養・食糧学会
    • Place of Presentation
      アスティー徳島(徳島市)
    • Year and Date
      2010-05-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 葉酸欠乏による高ホモシステイン血症に及ぼすベタインおよびコリンの効果2010

    • Author(s)
      劉穎、劉戟群、杉山公男
    • Organizer
      日本栄養・食糧学会
    • Place of Presentation
      アスティー徳島(徳島市)
    • Year and Date
      2010-05-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 血漿ホモシステイン濃度に及ぼすコリン欠乏の影響と食餌タンパク質レベルとの関係2010

    • Author(s)
      劉軟群、劉穎、杉山公男
    • Organizer
      日本栄養・食糧学会
    • Place of Presentation
      アスティー徳島(徳島市)
    • Year and Date
      2010-05-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 高タンパク質食摂取が血漿ホモシステイン濃度を上昇させない機構について2009

    • Author(s)
      呉育如 他
    • Organizer
      第64回日本栄養・食糧学会大会
    • Place of Presentation
      アクティー徳島
    • Year and Date
      2009-05-22
    • Related Report
      2011 Final Research Report
  • [Presentation] 葉酸欠乏による高ホモシステイン血症に及ぼすベタインおよびコリンの効果2009

    • Author(s)
      劉穎 他
    • Organizer
      第64回日本栄養・食糧学会大会
    • Place of Presentation
      アクティー徳島
    • Year and Date
      2009-05-22
    • Related Report
      2011 Final Research Report
  • [Presentation] 血漿ホモシステイン濃度に及ぼすコリン欠乏の影響と食餌タンパク質レベルとの関係2009

    • Author(s)
      劉軼群 他
    • Organizer
      第64回日本栄養・食糧学会大会
    • Place of Presentation
      アクティー徳島
    • Year and Date
      2009-05-22
    • Related Report
      2011 Final Research Report
  • [Presentation] ベタイン欠乏を伴う高ホモシステイン血症に及ぼすメチオニンとセリン添加の影響2009

    • Author(s)
      劉軼群 他
    • Organizer
      第64回日本栄養・食糧学会大会
    • Place of Presentation
      長崎ブリックホール
    • Year and Date
      2009-05-21
    • Related Report
      2011 Final Research Report
  • [Presentation] 血漿ホモシステイン濃度に及ぼす食餌タンパク質の種類と量の影響2009

    • Author(s)
      呉育如 他
    • Organizer
      第64回日本栄養・食糧学会大会
    • Place of Presentation
      長崎ブリックホール
    • Year and Date
      2009-05-21
    • Related Report
      2011 Final Research Report
  • [Presentation] タンパク質およびアミノ酸摂取量とラット肝臓CBS活性との関係2009

    • Author(s)
      大内誠也 他
    • Organizer
      第64回日本栄養・食糧学会大会
    • Place of Presentation
      長崎ブリックホール
    • Year and Date
      2009-05-21
    • Related Report
      2011 Final Research Report
  • [Presentation] タンパク質およびアミノ酸摂取量とラット肝臓CBS活性との関係2009

    • Author(s)
      大内誠也, 森誠, 高坂哲也, 杉山公男
    • Organizer
      日本栄養・食糧学会
    • Place of Presentation
      長崎ブリックホール
    • Year and Date
      2009-05-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] べたイン欠乏を伴う高ホモシステイン血症に及ぼす食餌へのメチオニンとセリン添加の影響2009

    • Author(s)
      劉軟群, 大内誠也, 杉山公男
    • Organizer
      日本栄養・食糧学会
    • Place of Presentation
      長崎ブリックホール
    • Year and Date
      2009-05-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] 血漿ホモシステイン濃度に及ぼす食餌タンパク質の種類と量の影響2009

    • Author(s)
      呉育如, 姚暁萍, 大内誠也, 杉山公男
    • Organizer
      日本栄養・食糧学会
    • Place of Presentation
      長崎ブリックホール
    • Year and Date
      2009-05-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] 食事因子による含硫アミノ酸代謝の制御に関する研究2009

    • Author(s)
      杉山公男
    • Organizer
      日本栄養・食糧
    • Place of Presentation
      長崎ブリックホール
    • Year and Date
      2009-05-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] BHMT活性に影響を及ぼす食餌因子とホモシステイン代謝2009

    • Author(s)
      劉軼群 他
    • Organizer
      第64回日本栄養・食糧学会大会
    • Place of Presentation
      お茶の水女子大学
    • Year and Date
      2009-05-15
    • Related Report
      2011 Final Research Report
  • [Presentation] コリン欠乏による高ホモシステイン血症に及ぼす葉酸の効果2009

    • Author(s)
      劉穎 他
    • Organizer
      第64回日本栄養・食糧学会大会
    • Place of Presentation
      お茶の水女子大学
    • Year and Date
      2009-05-15
    • Related Report
      2011 Final Research Report
  • [Presentation] 低メチオニン食へのシステイン添加による脂肪肝の生成について2009

    • Author(s)
      土屋諒 他
    • Organizer
      第64回日本栄養・食糧学会大会
    • Place of Presentation
      お茶の水女子大学
    • Year and Date
      2009-05-14
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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