Exploring of food components with neurotrophic activity
Project/Area Number |
21580140
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Food science
|
Research Institution | Okayama University |
Principal Investigator |
ITO Hideyuki 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (70253002)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | ポリフェノール / カテキン / キサントン / 海馬 / 神経突起伸展作用 / アルツハイマー型認知症 / 脳内移行 / アルツハイマー / マンゴスチン / アルツハイマー病 / 神経栄養因子 |
Research Abstract |
We have previously reported that chlorogenic acid, catechin and epicatechin were found to promote neuronal differentiation by using primary cultures of fetal rat hippocampal neurons in a serum-free medium. In this project, we evaluated brain absorption of these active compounds after oral administration to rat. Catechin was not detected in brain after catechin ingestion to rat, whereas its metabolite 3'-O-methylcatechin was observed by HPLC-ESI-MS/MS method. Our findings raise the possibility that studying the bioavailability of natural products is important to clarify the bioactive principles of their biological activities.
|
Report
(4 results)
Research Products
(81 results)
-
[Journal Article] Antioxidative properties of functional polyphenols and their metabolites assessed by an ORAC assay2012
Author(s)
Ishimoto, H., Tai, A., Yoshimura, M., Amakura, Y., Yoshida, T., Hatano, T., and Ito, H.
-
Journal Title
Biosci. Biotech. Biochem.
Volume: 76
Pages: 395-399
NAID
Related Report
Peer Reviewed
-
[Journal Article] Antioxidative Properties of Functional Polyphenols and Their Metabolites Assessed by an ORAC Assay2012
Author(s)
Ishimoto, H., Tai, A., Yoshimura, M., Amakura, Y., Yoshida, T., Hatano, T., Ito, H.
-
Journal Title
Bioscience, Biotechnology, and Biochemistry
Volume: 76
Issue: 2
Pages: 395-399
DOI
NAID
ISSN
0916-8451, 1347-6947
Related Report
Peer Reviewed
-
-
[Journal Article] UV and MS identification of urolithins and nasutins, the bioavailable metabolites of ellagitannins and ellagic acid in different mammals2011
Author(s)
Gonzalez-Barrio, R., Truchado, P., Ito, H., Espin, J. C., Tomas-Barberan, F. A.
-
Journal Title
J. Agric. Food. Chem.
Volume: 59
Pages: 1152-1162
Related Report
Peer Reviewed
-
[Journal Article] In vivo anti-inflammatory and antioxidant properties of ellagitannin metabolite urolithin A2011
Author(s)
Ishimoto, H., Shibata, M., Myojin, Y., Ito, H., Sugimoto, Y., Tai, A, Hatano, T.
-
Journal Title
Bioorg.Med.Chem.Lett.
Volume: 21
Issue: 19
Pages: 5901-5904
DOI
NAID
Related Report
Peer Reviewed
-
-
-
-
-
-
-
[Journal Article] Intramolecular acyl migration and enzymatic hydrolysis of a novel monoacylated ascorbic acid derivative, 6-0-dodecanoyl-2-0-α-D-glucopyranosyl-L-ascorbic acid2010
Author(s)
Tai, A., Mori, T., Urushihara, M., Ito, H., Kawasaki, D., Yamamoto, I.
-
Journal Title
Bioorg.Med.Chem.
Volume: 18
Pages: 6179-6183
Related Report
Peer Reviewed
-
-
-
[Journal Article] Quinolone analogues 10 : Synthesis of antimalarial quinolones having pyridyl moiety in N1-side chain2010
Author(s)
Kurasawa, Y., Yoshida, K., Yamazaki, N., Kaji, E., Sasaki, K., Hiwasa, Y., Tsukamoto, A., Ito, H.
-
Journal Title
J.Heterocyclic Chem.
Volume: 47
Pages: 657-663
Related Report
Peer Reviewed
-
-
[Journal Article] Production improvement of antifungal, antitrypanosomal nucleoside sinefungin by rpoB mutation and optimization of resting cell system of Streptomyces incarnatus NRRL 80892010
Author(s)
Fukuda, K., Tamura, T., Ito, H., Yamamoto, S., Ochi, K., Inagaki, K.
-
Journal Title
J.Biosci.Bioeng.
Volume: 109
Pages: 459-465
NAID
Related Report
Peer Reviewed
-
[Journal Article] New isoflavone glycosides from Iris spuria L. (Calizona)cultivated in Egypt2009
Author(s)
Farag, S.F., Kimura, Y., Ito, H., Takayasu, J., Tokuda, H., Hatano, T.
-
Journal Title
J. Nat. Med. 63
Pages: 91-95
NAID
Related Report
Peer Reviewed
-
[Journal Article] Interaction of polyphenols with proteins : Binding of(-)-epigallocatechin gallate to serum albumin, estimated by induced circular dichroism2009
Author(s)
Nozaki, A., Hori, M., Kimura, T., Ito, H., Hatano, T.
-
Journal Title
Chem. Pharm. Bull. 57
Pages: 224-228
NAID
Related Report
Peer Reviewed
-
[Journal Article] Effect of Polyphenol-Rich Extract from Walnut on Diet-Induced Hypertriglyceridemia in Mice via Enhancement of Fatty Acid Oxidation in the Liver2009
Author(s)
Shimoda, H., Tanaka, J., Kikuchi, M., Fukuda, T., Ito, H., Hatano, T., Yoshida, T.
-
Journal Title
J. Agric. Food Chem. 57
Pages: 1786-1792
Related Report
Peer Reviewed
-
[Journal Article] Different behavior of artemisinin and tetraoxane in the oxidative degradation of phospholipid2009
Author(s)
Kumura, N., Furukawa, H., Onyangob, A.N.Izumia, M., Nakajima, S., Ito, H., Hatano, T., Kim, H.-S., Wataya, Y., Baba, N.
-
Journal Title
Chem. Phys. Lipids 160
Pages: 114-120
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Book] Chemistry and biology of ellagitannins, Ellagitannins renewed the concept of tannins, An underestimated class of bioactive plant polyphenols-2009
Author(s)
Okuda, T., Yoshida, T., Hatano, T., and Ito, H., Quideau, S.
Publisher
World Scientific, Singapore
Related Report
-
[Book] Chemistry and biology of ellagitannins, Structural diversity and antimicrobial activities of ellagitannins, An underestimated class of bioactive plant polyphenols-2009
Author(s)
Yoshida, T., Hatano, T., Ito, H., and Okuda, T., Quideau, S.
Publisher
World Scientific, Singapore
Related Report
-
-