Studies on the structure-activity relationship of flaxseed lignan, multifunctional physiologically active substance
| Project/Area Number |
21580142
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Ehime University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAUCHI Satoshi 愛媛大学, 農学部, 教授 (00243808)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | アマニ / セコイソラリシレジノール / マタイレジノール / リグナン / 抗アレルギー / 免疫促進 / 脂肪蓄積抑制 / 構造活性相関 / 脂肪蓄積抑制効果 / 抗糖尿病効果 / 脂肪肝抑制 / アマニリグナン / 免疫促進効果 |
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| Research Abstract |
One of flaxseed lignans, matairesinol(Mat), especially(-)-Mat suppressed IgE production, and allergy-suppressing effects in allergy model mice. In addition,(-)-secoisolariciresinol(SECO) strongly suppressed lipid accumulation in adipose cells, even though(-)-SECO strongly induced adipogenesis in pre-adipocyte cells.(-)-SECO enhanced adiponectin production in adipocytes. Moreover,(-)-SECO obviously suppressed fatty liver in diabetic model mice.
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Report
(4 results)
Research Products
(36 results)
