• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Physiological functions of structured lipids

Research Project

Project/Area Number 21580145
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Food science
Research InstitutionSaga University

Principal Investigator

YANAGITA Teruyoshi  佐賀大学, 農学部, 教授 (00093980)

Co-Investigator(Kenkyū-buntansha) NAGAO Koji  佐賀大学, 農学部, 准教授 (10336109)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords脂質構造異性体 / 高脂血症 / 動脈硬化 / 糖尿病 / 高血圧
Research Abstract

The concept of a" structured-lipid" implies modification of the fatty acid composition and/ or their location in the glycerol backbone, and improvement of the physical and/ or physiological properties of dietary lipids. Our study demonstrated that bioactive lipids(such as conjugated linoleic acid and ozonized-olive oil) or structured lipids(such as dorphine-oil, n-3 structured lipids, and soy-PLs) displays at least two different physiological actions that alleviate obesity-induced diseases : one through the reduction of inflammatory damage by its suppression in productions of MCP-1 or PAI-1 and the other through an increase of adiponectin expression. Thus, possible findings on the effects of the form, such as PL, TAG or DAG, used for the administration of bioactive fatty acids, such as n-3 PUFA, CFA and MCFA, would be of great interest for future study.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (22 results)

All 2011 2010 2009

All Journal Article (15 results) (of which Peer Reviewed: 7 results) Presentation (2 results) Book (2 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] Suppressive effects of Bunashimeji(Hypsizigus marmoreus) on triacylglycerol accumulation in orotic acid-treated growing rats2011

    • Author(s)
      M. Ohtsuki, K. Morishima, K. Umeshita, N. Ohkubo, N. Niwa, T. Yanagita, Y. Furuichi
    • Journal Title

      J. Integ. Study Dietary Habits

      Volume: 22 Pages: 20-27

    • NAID

      10029399656

    • Related Report
      2011 Final Research Report
  • [Journal Article] New phenolic compounds from Camellia sinensis L. leaves fermented with Aspergillus sp2011

    • Author(s)
      RA. Wulandari, M. Amano, T. Yanagita, T. Tanaka, I. Kouno, D. Kawamura, K. Ishimaru
    • Journal Title

      J. Nat. Med.

      Volume: 65 Pages: 594-597

    • Related Report
      2011 Final Research Report
  • [Journal Article] Study on possible mechanism of orotic acid-induced fatty liver in rats2011

    • Author(s)
      YM. Wang, XQ Hu, Y. Xue, ZJ. Li, T. Yanagita, CH. Xue
    • Journal Title

      Nutrition

      Volume: 27 Pages: 571-575

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] New phenolic compounds from Camellia sinensis L.leaves fermented with Aspergillus sp2011

    • Author(s)
      RA.Wulandari, M.Amano, T.Yanagita, T.Tanaka, I.Kouno, D. Kawamura, K.Ishimaru
    • Journal Title

      J.Nat.Med.

      Volume: 65 Pages: 594-597

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppressive Effects of Bunashimeji (Hypsizigus marmoreus) on Triacylglycerol Accumulation in Orotic Acid-treated Growing Rats2011

    • Author(s)
      M.Ohtsuki, K.Morishima, K.Umeshita, N.Ohkubo, N.Niwa, T.Yanagita, Y.Furuichi
    • Journal Title

      Journal for the Integrated Study of Dietary Habits

      Volume: 22 Issue: 1 Pages: 20-27

    • DOI

      10.2740/jisdh.22.20

    • NAID

      130004493846

    • ISSN
      1346-9770, 1881-2368
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conjugated linoleic acid suppresses colon carcinogenesis in azoxymethane-pretreated rats with long-term feeding of diet containing beef tallow2010

    • Author(s)
      R. Shiraishi, R. Iwakiri, T. Fujise, T. Kuroki, T. Kakimoto, T. Takashima, Y. Sakata, S. Tsunada, Y. Nakashima, T. Yanagita, K. Fujimoto
    • Journal Title

      J. Gastroenterol.

      Volume: 45 Pages: 625-635

    • Related Report
      2011 Final Research Report
  • [Journal Article] Physiological effects of dietary PIPS soybean-derived phospholipid in obese Zucker(fa/ fa) rats2010

    • Author(s)
      B. Shirouchi, K. Nagao, K. Furuya, M. Shiojiri, X. Liu, T. Yanagita
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: 74 Pages: 2333-2335

    • NAID

      10027561920

    • Related Report
      2011 Final Research Report
  • [Journal Article] Physiological functions of iso-type short-chain fatty acid and omega 3 polyunsaturated fatty acids containing oil in obese OLETF rats2010

    • Author(s)
      B. Shirouchi, K. Nagao, K. Furuya, T. Nagai, K. Ichioka, S. Tokairin, Y. Iida, T. Yanagita
    • Journal Title

      J. Oleo Sci.

      Volume: 59 Pages: 299-305

    • NAID

      130000253587

    • Related Report
      2011 Final Research Report
  • [Journal Article] Physiological functions of iso-type short-chain fatty acid and omega 3 polyunsaturated fatty acids containing oil in obese OLETF rats.2010

    • Author(s)
      Shirouchi B., K.Nagao, K.Furuya, T.Nagai, K.Ichioka, S.Tokairin, Y.Iida, T.Yanagita
    • Journal Title

      J.Oleo Sci.

      Volume: 59 Pages: 299-305

    • NAID

      130000253587

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Physiological effects of dietary PIPS soybean-derived phospholipid in obese Zucker (fa/fa) rats.2010

    • Author(s)
      Shirouchi B., K.Nagao, K.Furuya, M.Shiojiri, X.Liu, T.Yanagita
    • Journal Title

      Biosci.Biotechnol.Biochem

      Volume: 74 Pages: 2333-2335

    • NAID

      10027561920

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conjugated linoleic acid suppresses colon carcinogenesis in azoxymethan e-pretreated rats with long-term feeding of diet containing beef tallow.2010

    • Author(s)
      Shiraishi R., R.Iwakiri, T.Fujise, T.Kuroki, T.Kakimoto, T.Takashima, Y.Sakata, S.Tsunada, Y.Nakashima, T.Yanagita, K.Fujimoto
    • Journal Title

      J.Gastroenterol.

      Volume: 45 Pages: 625-635

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of three different highly purified n-3 series highly unsaturated fatty acids on lipid metabolism in C57BL/ KsJ-db/ db Mice2009

    • Author(s)
      N. Gotoh, K. Nagao, S. Onoda, B. Shirouchi, K. Furuya, T. Nagai, H. Mizobe, K. Ichioka, H. Watanabe, T. Yanagita, S. Wada
    • Journal Title

      J. Agric. Food Chem.

      Volume: 57 Pages: 11047-11054

    • Related Report
      2011 Final Research Report
  • [Journal Article] Linoleic acid-menthyl ester reduces the secretion of apolipoprotein B100 in HepG2 cells2009

    • Author(s)
      Inoue, Yamano, K. Sakata, K. Arao, T. Kobayashi, T. Nagao, Y. Shimada, K. Nagao, T. Yanagita
    • Journal Title

      J. Oleo Sci

      Volume: 58 Pages: 171-175

    • NAID

      130000437061

    • Related Report
      2011 Final Research Report
  • [Journal Article] Linoleic acid-menthyl ester reduces the secretion of apolipoprotein B100 in HepG2 cells.2009

    • Author(s)
      N.Inoue, N.Yamano, K.Sakata, K.Arao, T.Kobayashi, T.Nagao, Y.Shimada, K.Nagao, T.Yanagita
    • Journal Title

      J.Oleo Sci. 58

      Pages: 171-175

    • NAID

      130000437061

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Three Kinds of Highly Purified n-3 Series Highly Unsaturated Fatty Acids on Lipid Metabolism in C57BL/KsJ-db/db Mice.2009

    • Author(s)
      N.Gotoh, K.Nagao, S.Onoda, B.Shirouchi, K.Furuya, T.Nagai, H.Mizobe, K.Ichioka, H.Watanabe, T.Yanagita, S.Wada
    • Journal Title

      J.Agric.Food Chem. 57

      Pages: 11047-11054

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] オゾン化脂質摂取が肥満ラットの病態発症に及ぼす影響2011

    • Author(s)
      迫尾昌美、甲斐俊一、永尾晃治、小島浩一、永井利治、柳田晃良
    • Organizer
      平成23年度日本栄養・食糧学会九州・沖縄支部および日本食品科学工学会西日本支部合同大会
    • Place of Presentation
      佐賀市
    • Year and Date
      2011-09-04
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] リン脂質の塩基部分含有食が肥満ラットの病態発症に及ぼす影響2011

    • Author(s)
      古賀美里、甲斐俊一、永尾晃治、柳田晃良
    • Organizer
      平成23年度日本栄養・食糧学会九州・沖縄支部および日本食品科学工学会西日本支部合同大会
    • Place of Presentation
      佐賀市
    • Year and Date
      2011-09-04
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Book] Omega-3 Oils : Applications in Functional Foods, ed. by EM. Hernandez, M. Hosokawa2011

    • Author(s)
      B. Shirouchi, K. Nagao, T. Yanagita
    • Publisher
      AOCS press
    • Related Report
      2011 Final Research Report
  • [Book] Omega-3 Oils : Applications in Functional Foods(ed.by EM.Hernandez, M.Hosokawa)2011

    • Author(s)
      (分担執筆)B.Shirouchi, K.Nagao, T.Yanagita
    • Publisher
      AOCS press, USA
    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] 肝機能障害予防改善剤2011

    • Inventor(s)
      柳田晃良、永尾晃治、小島浩一、永井利治
    • Industrial Property Rights Holder
      佐賀大学、月島食品工業株式会社
    • Filing Date
      2011-08-18
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 脂質代謝改善用組成物2011

    • Inventor(s)
      柳田晃良、永尾晃治、荒尾慶介、井上奈穂、王玉明、岩田敏夫
    • Industrial Property Rights Holder
      佐賀大学、日清オイリオグループ
    • Acquisition Date
      2011-11-04
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 肝機能障害予防改善剤2011

    • Inventor(s)
      柳田晃良、永尾晃治、小島浩一、永井利治
    • Industrial Property Rights Holder
      佐賀大学、月島食品工業株式会社
    • Industrial Property Number
      2011-179202
    • Filing Date
      2011-08-18
    • Related Report
      2011 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi