PHYSIOLOGICAL FUNCTIONS OF WATER-SOLUBLE FLAVONOID DERIVATIVES IN OSTEOPOROTIC RODENTS
Project/Area Number |
21580155
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Food science
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Research Institution | Tokyo University of Agriculture |
Principal Investigator |
UEHARA Mariko 東京農業大学, 応用生物科学部, 教授 (20211071)
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Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | イソフラボン / ヘスペリジン / 水溶性フラボノイド / サイクロデキストリン / 原発性骨粗鬆症 / 続発性骨粗鬆症 / 2型糖尿病 / 卵巣摘出骨粗鬆症モデルマウス / マグネシウム欠乏ラット / 糖尿病モデルラット |
Research Abstract |
Since native flavonoids are typical hydrophobic compounds, the compounds have not been frequently used as multipurpose food additives. Enzymatic modified-soy bean isoflavone and hesperidin, and cyclodextrin-clathrated(CD) hesperetin, a citrus bioflavonoid, have higher water-solubility than native corresponding flavonoids. Those water-soluble flavonoid derivates showed high bioavailability, and especially, CD-hesperetin improved secondary osteoporosis in both weanling and old type 2 diabetic rodents.
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Report
(4 results)
Research Products
(44 results)
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[Journal Article] Plasma concentrations of oxidized low-density lipoprotein are related to blood glucose concentration but not to total peroxyl radical-trapping potential2010
Author(s)
Ihara H, Oikawa Y, Kakinoki T, Morita N, Matsumoto N, Yoshino S, Takamiya K, Suzuki M, Katsumata SI, Uehara M, Hashizume N
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Journal Title
Journal of Analytical Bio-Science
Volume: Vol.33
Pages: 366-370
Related Report
Peer Reviewed
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