PHYSIOLOGICAL FUNCTIONS OF WATER-SOLUBLE FLAVONOID DERIVATIVES IN OSTEOPOROTIC RODENTS

• Project/Area Number: 21580155
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Food science
• Research Institution: Tokyo University of Agriculture
• Principal Investigator: UEHARA Mariko 東京農業大学, 応用生物科学部, 教授 (20211071)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: イソフラボン / ヘスペリジン / 水溶性フラボノイド / サイクロデキストリン / 原発性骨粗鬆症 / 続発性骨粗鬆症 / 2型糖尿病 / 卵巣摘出骨粗鬆症モデルマウス / マグネシウム欠乏ラット / 糖尿病モデルラット

Research Abstract

Since native flavonoids are typical hydrophobic compounds, the compounds have not been frequently used as multipurpose food additives. Enzymatic modified-soy bean isoflavone and hesperidin, and cyclodextrin-clathrated(CD) hesperetin, a citrus bioflavonoid, have higher water-solubility than native corresponding flavonoids. Those water-soluble flavonoid derivates showed high bioavailability, and especially, CD-hesperetin improved secondary osteoporosis in both weanling and old type 2 diabetic rodents.

Research Products

• [Journal Article] Synergistic effect of isoflavone glycosides and fructooligosaccharides on postgastrectomy osteopenia in rats (2012)
  • Author(s): Kimira Y, Tajima K, Ohta A, Ishimi Y, Katsumata SI, Suzuki K, Adlercreutz H, Uehara M
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 51 Issue: 2 Pages: 156-160
  • DOI: 10.3164/jcbn.D-12-00010
  • NAID: 130004879305
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed
• [Journal Article] Effects of anthocyanin-rich tea "Sunrouge" on dextran sodium sulfate-induced colitis in mice (2012)
  • Author(s): Akiyama S, Nesumi A, Maeda-Yamamoto M, Uehara M, Murakami A
  • Journal Title: Biofactors Volume: (Epub ahead of print) Issue: 3 Pages: 226-233
  • DOI: 10.1002/biof.1008
  • Peer Reviewed
• [Journal Article] Resistant starch promotes equol production and inhibits tibialbone loss in ovariectomized mice treated with daidzein (2011)
  • Author(s): Tousen Y, Abe F, Ishida T, Uehara M, Ishimi Y
  • Journal Title: Metabolism Volume: 60 Issue: 10 Pages: 1425-1432
  • DOI: 10.1016/j.metabol.2011.02.009
  • Peer Reviewed
• [Journal Article] Combined effects of soy isoflavone andfish oil on ovariectomy-induced boneloss in mice (2011)
  • Author(s): Uchida R, Chiba H, Ishimi Y, Uehara M, Suzuki K, Kim H, Matsumoto A
  • Journal Title: JBone Miner Metab Volume: 29 Issue: 4 Pages: 404-413
  • DOI: 10.1007/s00774-010-0234-8
  • Peer Reviewed
• [Journal Article] 栄養素代謝におけるマグネシウムの重要性 (2010)
  • Author(s): 上原万里子、石島智子、松本一朗、岡田晋司、荒井綜一、阿部啓子、勝間田真一、松崎広志、鈴木和春
  • Journal Title: 日本海水学会誌 Volume: 29巻 Pages: 202-210
  • NAID: 10026551793
• [Journal Article] The frequency of magnesium consumption directly influences its serum concentration and the amount of elutable bone magnesium in rats (2010)
  • Author(s): Nakaya Y, Uehara M, Katsumata S, Suzuki K, Sakai K, Ohnishi R, Akiyama S, Ohta A
  • Journal Title: Magnes Res Volume: 23 Pages: 48-56
  • URL: http://www.jle.com/en/revues/bio_rech/mrh/e-docs/00/04/55/45/resume.phtml
  • Peer Reviewed
• [Journal Article] Dietary hesperidin exerts hypoglycemic and hypolipidemic effects in streptozotocininduced marginal type 1 diabetic rats (2010)
  • Author(s): Akiyama S, Katsumata S, Suzuki K, Ishimi Y, Wu J, Uehara M
  • Journal Title: J Clin Biochem Nutr Volume: 46 Pages: 87-9
  • NAID: 130004466600
  • URL: http://dx.doi.org/10.3164/jcbn.09-82
  • Peer Reviewed
• [Journal Article] Inability of magnesium-deficient rats to choose a diet with high magnesium content (2010)
  • Author(s): Nakaya Y, Uehara M, Katsumata SI, Suzuki K, Sakai K, Ohnishi R, Akiyama S, Ohta A
  • Journal Title: マグネシウム Volume: 29巻 Pages: 5-15
  • Peer Reviewed
• [Journal Article] 栄養素代謝におけるマグネシウムの重要性 (2010)
  • Author(s): 上原万里王、石島智子、松本一朗、岡田晋司、荒井綜一、阿部啓子、勝間田真一、松崎広志、鈴木和春
  • Journal Title: 日本海水学会誌 Volume: 64巻 Pages: 202-210
  • NAID: 10026551793
• [Journal Article] Plasma concentrations of oxidized low-density lipoprotein are related to blood glucose concentration but not to total peroxyl radical-trapping potential (2010)
  • Author(s): Ihara H, Oikawa Y, Kakinoki T, Morita N, Matsumoto N, Yoshino S, Takamiya K, Suzuki M, Katsumata SI, Uehara M, Hashizume N
  • Journal Title: Journal of Analytical Bio-Science Volume: Vol.33 Pages: 366-370
  • Peer Reviewed
• [Journal Article] Dietary hesperidin exerts hypoglycemic and hypolipidemic effects in streptozotocin-induced marginal type 1 diabetic rats. (2010)
  • Author(s): Akiyama S, Katsumata S, Suzuki K, Ishimi Y, Wu J, Uehara M.
  • Journal Title: Journal of Clinical Biochemistry and Nutrition VOL.46 Pages: 87-92
  • NAID: 130004466600
  • Peer Reviewed
• [Journal Article] The frequency of magnesium consumption directly influences its serum concentration and the amount of elutable bone magnesium in rats. (2010)
  • Author(s): Nakaya Y, Uehara M, Katsumata SI, Suzuki K, Sakai K, Ohnishi R, Akiytama S, Ohta A.
  • Journal Title: Magnesium Research VOL.23 Pages: 48-56
  • Peer Reviewed
• [Journal Article] Hypoglycemic and hypolipidemic effects of hesperidin and cyclodextrinclathrated hesperetin in Goto-Kakizaki rats with type 2 diabetes (2009)
  • Author(s): Akiyama S, Katsumata S, Suzuki K, Nakaya Y, Ishimi Y, Uehara M
  • Journal Title: Biosci Biotechnol Biochem Volume: 73 Pages: 2779-82
  • URL: http://dx.doi.org/10.1271/bbb.90576
  • Peer Reviewed
• [Journal Article] Distribution and major sources of flavonoid intakes in the middle-agedJapanese women (2009)
  • Author(s): Otaki N, Kimira M, Katsumata S, Uehara M, Watanabe S, Suzuki K
  • Journal Title: J Clin BiochemNutr Volume: 44 Pages: 231-238
  • URL: http://dx.doi.org/10.3177/jnsv.55.332
  • Peer Reviewed
• [Journal Article] ヘスペリジンの骨粗鬆症予防作用 (2009)
  • Author(s): 上原万里子
  • Journal Title: FOOD STYLE 21 Volume: 13巻 Pages: 32-34
• [Journal Article] 骨リモデリングと骨質を高める食品 (2009)
  • Author(s): 上原万里子、秋山聡子
  • Journal Title: 食品と開発 Volume: 44巻 Pages: 12-15
• [Journal Article] Distribution and major sources of flavonoid intakes in the middle-aged Japanese women. (2009)
  • Author(s): Otaki N, Kimira M, Katsumata S, Uehara M, Watanabe S, Suzuki K.
  • Journal Title: Journal of Clinical Biochemistry and Nutrition VOL.44 Pages: 231-238
  • NAID: 130004466545
  • Peer Reviewed
• [Journal Article] Hypoglycemic and hypolipidemic effects of hesperidin and cyclodextrin-clathrated hesperetin in Goto-Kakizaki rats with type 2 diabetes. (2009)
  • Author(s): Akiyama S, Katsumata SI, Suzuki K, Nakaya Y, Ishimi Y, Uehara M.
  • Journal Title: Bioscience, Biotechnology, and Biochemistry VOL.73 Pages: 2779-2782
  • NAID: 10027549558
  • Peer Reviewed
• [Journal Article] Absence of negative feedback on intestinal magnesium absorption on excessive magnesium administration in rats. (2009)
  • Author(s): Nakaya Y, Suzuki M, Uehara M, Katsumata SI, Suzuki K, Sakai K, Ohnishi R, Ohta A.
  • Journal Title: Journal of Nutritional Science and Vitaminology VOL.55 Pages: 332-337
  • NAID: 10025971717
  • Peer Reviewed
• [Journal Article] 骨の健康を考える「ヘスペリジンの骨粗鬆症予防作用」 (2009)
  • Author(s): 上原万里子
  • Journal Title: FOOD STYLE 21 13巻 Pages: 32-34
• [Journal Article] 骨リモデリングと骨質を高める食品成分 (2009)
  • Author(s): 上原万里子, 秋山聡子
  • Journal Title: 食品と開発 44巻 Pages: 12-15
• [Journal Article] Synergistic effect of isoflavoneglycosidesand fructooligosaccharides on postgastrectomyosteopenia in rats
  • Author(s): Kimira Y, Tajima K, Ohta A, Ishimi Y, Katsumata SI, Suzuki K, Adlercreutz H, Uehara M
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Combined effects of soy isoflavone and fish oil on ovariectomy-induced bone loss in mice.
  • Author(s): Uchida R, Chiba H, Ishimi Y, Uehara M, Suzuki K, Kim H, Matsumoto A.
  • Journal Title: Journal of Bone and Mineral Metabolism Volume: (Epub ahead of print)
  • NAID: 10029298838
  • Peer Reviewed
• [Presentation] 骨粗鬆症モデルマウスの骨量減少におけるequol鏡像異性体の効果の比較 (2012)
  • Author(s): 君羅好史、勝開田真一、鈴木和春、石見佳子、上原万里子
  • Organizer: 日本農芸化学会2012年大会
  • Place of Presentation: 京都女子大学(京都)
  • Year and Date: 2012-03-23
• [Presentation] Possible roles of phytochemicals onbone quality in rodent models of osteoporosis (2011)
  • Author(s): Uehara M, Kimira1 Y, Katsumata SI, Akiyama S, Ishimi Y, Chiba H, Suzuki K
  • Organizer: International Conference of Food Factors(ICoFF) 2011
  • Place of Presentation: International Conference Center(Taipei, Taiwan)
  • Year and Date: 2011-11-22
• [Presentation] Food diversification in Japan : Recent development in functional foods (2011)
  • Author(s): Uehara M
  • Organizer: International Societyfor Southeast Asian AgriculturalScience(ISSAAS) 2011
  • Place of Presentation: IPB International Convention Center(Bogor, Indonesia)
  • Year and Date: 2011-11-07
• [Presentation] Food diversification in Japan : Recent development in functional foods (2011)
  • Author(s): Uehara M
  • Organizer: International Society for Southeast Asian Agricultural Science (ISSAAS)2011
  • Place of Presentation: IPB International Convention Center (Bogor, Indonesia)(招待)
  • Year and Date: 2011-11-07
• [Presentation] Possible roles of phytochemicals on bone quality in rodent models of osteoporosis (2011)
  • Author(s): Uehara M, Kimiral Y, Katsumata SI, Akiyama S, Ishimi Y, Chiba H, Suzuki K
  • Organizer: International Conference of Food Factors (ICoFF)2011
  • Place of Presentation: International Conference Center (Taipei, Taiwan)(招待)
  • Year and Date: 2011-11-04
• [Presentation] フラクトオリゴ糖併用摂取による骨粗鬆症モデルマウスの骨量減少に対する大豆イソフラボン投与量低減の可能性 (2011)
  • Author(s): 君羅好史、勝間田真一、太田篤胤、石見佳子、鈴木和春、上原万里子
  • Organizer: 第65回日本栄養・食糧学会大会
  • Place of Presentation: お茶の水女子大学(東京)
  • Year and Date: 2011-05-15
• [Presentation] ダイゼインとレジスタントスターチの併用摂取が骨粗鬆症モデルマウスのエクオール産生および骨量減少に及ぼす影響 (2011)
  • Author(s): 東泉裕子、阿部文子、石田達也、上原万里子、石見佳子
  • Organizer: 第65回日本栄養・食糧学会大会
  • Place of Presentation: お茶の水女子大学(東京)
  • Year and Date: 2011-05-15
• [Presentation] Risk-benefit assessment of soy isoflavones and their metabolites (2010)
  • Author(s): Uehara M, Kimira Y, Katsumata SI, Suzuki K, Ueno T, Uchiyama S, Adlercreutz H, Wu J, Ishimi, Y
  • Organizer: PACIFICHEM2010
  • Place of Presentation: Hawaii Convention Center(USA)
  • Year and Date: 2010-12-17
• [Presentation] Risk-benefit assessment of soy isoflavones and their metabolites (2010)
  • Author(s): Uehara M, Kimira Y, Katsumata SI, Suzuki K, Ueno T, Uchiyama S, Adlercreutz H, Wu J, Ishimi, Y
  • Organizer: PACIFICHEM2010
  • Place of Presentation: Hawaii Convention Center (USA)
  • Year and Date: 2010-12-17
• [Presentation] 閉経後骨粗鬆症モデルマウスの骨量減少に対するS体およびラセミ体equolの効果の差異 (2010)
  • Author(s): 君羅好史、勝間田真一、石見佳子、上野友美、内山成人、鈴木和春、上原万里子
  • Organizer: 第15回日本フードファクター学会学術集会
  • Place of Presentation: 仙台市民会館(宮城県)
  • Year and Date: 2010-10-04
• [Presentation] 閉経後骨粗髪症モデルマウスの骨量減少に対するキシロオリゴ糖投与の影響 (2010)
  • Author(s): 見城紗織、勝問田真一、鎌田育子、五木田智夫、大渕貴之、安住尚也、鈴木和春、上原万里子
  • Organizer: 第15回日本フードファクター学会学術集会
  • Place of Presentation: 仙台市民会館(宮城県)
  • Year and Date: 2010-10-04
• [Presentation] 日本における最近の機能性食品の展開 (2010)
  • Author(s): 上原万里子
  • Organizer: 日本食品科学工学会第57回大会ランチョンシンポジウム「アジアにおける機能性食品の展開-Part5-」
  • Place of Presentation: 東京農業大学(東京都)
  • Year and Date: 2010-09-02
• [Presentation] 糖転移ヘスペリジンと未処理ヘスペリジンによる骨代謝調整作用の差異 (2010)
  • Author(s): 千葉大成、上原万里子、石見佳子、鈴木和春、金賢珠、松本明世
  • Organizer: 第46回日本栄養・食糧学会大会
  • Place of Presentation: アスティ徳島(徳島県)
  • Year and Date: 2010-05-23
• [Presentation] 糖転移ヘスペリジンと未処理ヘスペリジンによる骨代謝調整作用の差異 (2010)
  • Author(s): 千葉大成、上原万里子、石見佳子、鈴木和春、金賢珠、松本明世
  • Organizer: 第64回日本栄養・食糧学会大会
  • Place of Presentation: アスティとくしま(徳島県)
  • Year and Date: 2010-05-23
• [Presentation] 成熟雌ラットにおける高用量イソフラボン投与とフラクトオリゴ糖の相互作用 (2010)
  • Author(s): 君羅好史, 勝間田真一, 鈴木和春, 太田篤胤, 石見佳子, 上原万里子
  • Organizer: 日本農芸化学会2010年度大会
  • Place of Presentation: 東京
  • Year and Date: 2010-03-30
• [Presentation] Hypoglycaemic and hypolipidaemic effects of hesperetin glycosides prevent diabetic osteopathy in type 2 diabetic rats (2009)
  • Author(s): Uehara M, Akiyama S, Katsumta SI, Ishimi Y, Suzuki K
  • Organizer: International Conference on Polyphenols and Health 2009(ICPH2009)
  • Place of Presentation: Harrogate, UK
  • Year and Date: 2009-12-09
• [Presentation] Hypoglycaemic and hypolipidaemic effects of hesperetin glycosides prevent diabetic osteopathy in type 2 diabetic rats. (2009)
  • Author(s): Uehara M, Akiyama S, Katsumta SI, Ishimi Y, Suzuki K.
  • Organizer: International Conference on Polyphenols and Health 2009 (ICPH2009)
  • Place of Presentation: Harrogate, UK
  • Year and Date: 2009-12-09
• [Presentation] Magnesium status affects nutrient metabolism (2009)
  • Author(s): Uehara M, Nemoto T, Matsumoto I, Okada S, Arai S, Abe K, Katsumata SI, Suzuki K
  • Organizer: 9th International Symposium on Salt
  • Place of Presentation: Beijing, China
  • Year and Date: 2009-09-06
• [Book] 機能性食品素材の骨と軟骨への応用 (2011)
  • Author(s): 上原万里子、石見佳子
  • Total Pages: 252
  • Publisher: シーエムシー出版
• [Book] 機能性食品素材の骨と軟骨への応用 (2011)
  • Author(s): 上原万里子・石見佳子監修(第II編第5章および第18章執筆)
  • Total Pages: 252
  • Publisher: シーエムシー出版
• [Book] 食品機能栄養学 (2010)
  • Author(s): 五十嵐喜治、上原万里子、長田恭一、駒井三千夫、八村敏志、福島道弘
  • Total Pages: 167
  • Publisher: 三共出版