The study of the immune responses of the large intestine regulated by the commensal bacteria and the immunomodulation by foods
Project/Area Number |
21580158
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Food science
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Research Institution | Nihon University |
Principal Investigator |
HOSONO Akira 日本大学, 生物資源科学部, 准教授 (70328706)
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Co-Investigator(Kenkyū-buntansha) |
KAMINOGAWA Shuici 日本大学, 生物資源科学部, 教授 (50011945)
TAKAHASHI Kyoko 日本大学, 生物資源科学部, 講師 (70366574)
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Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 腸内細菌 / 大腸 / 免疫 / IgA / 共生 / 腸内共生菌 |
Research Abstract |
There are huge numbers of commensal bacteria in the large intestine. In this study, we have found the immunoregulatory mechanism of anti-infectious responses(e. g. IgA production and germinal center formation) and the hyporesponsiveness of mucosal immunocytes to commensal bacteria in the large intestine.
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Report
(4 results)
Research Products
(134 results)
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[Journal Article] Bacteroidesを定着させたノトバイオートマウスのパイエル板細胞は他の腸内共生菌の刺激に対しても効率的にIgA産生を誘導する2010
Author(s)
大山尭人, 細野朗, 鈴木あみ, 柳橋努, 津田真人, 八村敏志, 高橋宜聖, 伊藤喜久治, 平山和宏, 高橋恭子, 上野川修一
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Journal Title
無菌生物
Volume: 40
Pages: 64-68
NAID
Related Report
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[Journal Article] Bacteroidesを定着させたノトバイオートマウスのバイエル板細胞は他の腸内共生菌の刺激に対しても効率的にIgA産生を誘導する2010
Author(s)
大山尭人, 細野朗, 鈴木あみ, 柳橋努, 津田真人, 八村敏志, 高橋宜聖, 伊藤喜久治, 平山和宏, 直橋恭子, 上野川修一
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Journal Title
無菌生物
Volume: 40
Pages: 64-68
Related Report
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[Presentation] Lactobacillus mono-associated mice might be down-regulated the serum antibody levels induced by dietary antigen compared with Bacteroides mono-associated mice2012
Author(s)
Hamamoto Y, Hosono A, Tsuda M, Kamoi D, Hachimura S, Momose Y, Itoh K, Hirayama K, Takahashi K, Kaminogawa S
Organizer
The joint Meeting of the 17th International Symposium on Gnotobiology(ISG) and the 34th Congress of the Society for Microbial Ecology and Disease(SOMED)
Place of Presentation
Yokohama, Japan
Related Report
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[Presentation] Lactobacillus mono-associated mice might be down-regulated the serum antibody levels induced by dietary antigen compared with Bacteroides mono-associated mice2012
Author(s)
Yuji Hamamoto, Akira Hosono, Masato Tsuda, Daiki Kamoi, Satoshi Hachimura, Yoshika Momose, Kikuji Itoh, Kazuhiro Hirayama, Kyoko Takahashi, Shuichi Kaminogawa
Organizer
The joint Meeting of the 17th International Symposium on Gnotobiology (ISG) and the 34th Congress of the Society for Microbial Ecology and Disease (SOMED)
Place of Presentation
Yokohama, Japan
Related Report
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[Presentation] Bacteroidesを定着させたノトバイオートマウスのパイエル板細胞は他の腸内共生菌の刺激に対しても効率的にIgA産生を誘導する2010
Author(s)
大山尭人, 細野朗, 鈴木あみ, 柳橋努, 津田真人, 八村敏志, 高橋宜聖, 伊藤喜久治, 平山和宏, 高橋恭子, 上野川修一
Organizer
第43回日本無菌生物ノートバイオロジー学会総会
Place of Presentation
東京
Related Report
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[Presentation] Bacteroides を定着させたノトバイオートマウスのパイエル板細胞は他の腸内共生菌の刺激に対しても効率的にIgA産生を誘導する2010
Author(s)
大山尭人, 細野朗, 鈴木あみ, 柳橋努, 津田真人, 八村敏志, 高橋宜聖, 伊藤喜久治, 平山和宏, 高橋恭子, 上野川修一
Organizer
第43回日本無菌生物ノートバイオロジー学会総会
Place of Presentation
東京
Related Report
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[Presentation] 経口免疫寛容により誘導されるCD62L/CD44発現の異なる制御性T細胞の抑制機能2010
Author(s)
村上仁, 八村敏志, 田邊康祐, 足立(中嶋)はるよ, 津田真人, 若月芳雄, 佐藤隆一郎, 高橋恭子, 清野宏, 細野朗, 上野川修
Organizer
日本農芸化学会2010年度大会
Place of Presentation
東京
Related Report
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[Presentation] Bacteroides の刺激を受けたパイエル板細胞におけるIgA誘導の特徴2010
Author(s)
大山尭人, 細野朗, 鈴木あみ, 柳橋努, 津田真人, 八村敏志, 高橋宜聖, 伊藤喜久治, 平山和宏, 高橋恭子, 上野川修一
Organizer
日本農芸化学会2010年度大会
Place of Presentation
東京
Related Report
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[Presentation] CD3-IL-2R^+Peyer's patch cells respond to microbial stimuli, migrate to the lamina propria, secrete IL-5, and induce IgA production.2009
Author(s)
Umeda Y, Oawa S, Kaoka M, Takahashi Y, Itoh K, Yamada K, Kouro T, Tsuji N M, Hosono A, Totsuka M, Takatsu K, Kaminogawa S, Sato R, Hachimura S
Organizer
The 14th International Congress of Mucosal Immunology(ICMI 2009)
Place of Presentation
Boston, Massachusetts, USA
Related Report
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[Presentation] CD3^-IL-2R^+ Peyer's patch cells respond to microbial stimuli, migrate to the lamina propria, secrete IL-5, and induce IgA production2009
Author(s)
UMEDA Yukiko, OGAWA Shimpei, KURAOKA Masayuki, TAKAHASHI Yoshimasa, ITOH Kikuji, YAMADA Kiyoshi, KOURO Taku, TSUJI Noriko M, HOSONO Akira, TOTSUKA Mamoru, TAKATSU Kiyoshi, KAMINOGAWA Shuichi, SATO Ryuichiro, HACHIMURA Satoshi
Organizer
The 14th International Congress of Mucosal Immunoloev(ICMI 2009)
Place of Presentation
Boston, Massachusetts, USA
Related Report
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[Presentation] 抗原の経口摂取により誘導されるCD62L/CD44発現の異なる制御性T細胞の抑制機能/Regulatory function of T cells with different expression pattern of CD62L/CD44, induced by oral administration of antigen2009
Author(s)
村上仁, 八村敏志, 田邊康祐, 足立(中嶋)はるよ, 津田真人, 若月芳雄, 佐藤隆一郎, 高橋恭子, 細野朗, 上野川修
Organizer
第39回日本免疫学会総会・学術集会
Place of Presentation
大阪
Related Report
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