Physiological function of RegIV, an antimicrobial lectin secreted from intestinal epithelia
Project/Area Number |
21580159
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Food science
|
Research Institution | Meiji University |
Principal Investigator |
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 食品安全性 / 感染防御 / 腸管上皮 / 自然免疫 / レクチン |
Research Abstract |
Function of RegIV, an antimicrobial lectin secreted from intestinal epithelia, was analyzed using recombinant human RegIV protein. Analysis of ligand binding property using sugar-coupled beads revealed that recombinant RegIV binds peptidoglycan form gram-positive bacteria. It was also shown that RegIV elicits bactericidal activity on E. coli through membrane permeabilization.
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Report
(4 results)
Research Products
(4 results)