Physiological function of RegIV, an antimicrobial lectin secreted from intestinal epithelia

Research Project

Project/Area Number	21580159
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Food science
Research Institution	Meiji University
Principal Investigator	WATANABE Hirohito 明治大学, 農学部, 准教授 (20270895)
Project Period (FY)	2009 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000) Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords	食品安全性 / 感染防御 / 腸管上皮 / 自然免疫 / レクチン
Research Abstract	Function of RegIV, an antimicrobial lectin secreted from intestinal epithelia, was analyzed using recombinant human RegIV protein. Analysis of ligand binding property using sugar-coupled beads revealed that recombinant RegIV binds peptidoglycan form gram-positive bacteria. It was also shown that RegIV elicits bactericidal activity on E. coli through membrane permeabilization.

Report

(4 results)