| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
The effects of alterations of the intracellular composition of fatty acids on insulin secretion by cultured murine pancreatic β cells(MIN6 cells) was evaluated. The insulin secretion from MIN6 cells was enhanced most efficiently by oleic acid, followed by linoleic acid and α-linolenic acid, when each fatty acid was treated transiently at the same molar concentration. On the other hand, preincubation with each fatty acid for 72 hr in advance changed the intracellular composition of fatty acids and the most efficient effect of insulin secretion under this condition was elicited by α-linolenic acid. These results suggest that the insulin secreting activity of cultured MIN6 cells is affected by the intracellular composition of fatty acids.
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