Research on correlations between the intracellular composition of fatty acids and the protein degradation machinery of insulin secretion-related enzymes.
| Project/Area Number |
21580163
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Okayama University of Science (2011)
Doshisha University (2009-2010) |
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Principal Investigator |
ANDO Hideya 岡山理科大学, 工学部, 教授 (60454493)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 酵素 / 細胞 / 組織 / 脂質 / 蛋白質分解 / 糖尿病 / 細胞・組織 / 脂肪酸 / インシュリン / 培養細胞 / ユビキチン化 / タンパク質分解 |
|---|
| Research Abstract |
The effects of alterations of the intracellular composition of fatty acids on insulin secretion by cultured murine pancreatic β cells(MIN6 cells) was evaluated. The insulin secretion from MIN6 cells was enhanced most efficiently by oleic acid, followed by linoleic acid and α-linolenic acid, when each fatty acid was treated transiently at the same molar concentration. On the other hand, preincubation with each fatty acid for 72 hr in advance changed the intracellular composition of fatty acids and the most efficient effect of insulin secretion under this condition was elicited by α-linolenic acid. These results suggest that the insulin secreting activity of cultured MIN6 cells is affected by the intracellular composition of fatty acids.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] 1-(2, 4-Dihydroxyphenyl)-3-(2, 4-dimethoxy-3-methylphenyl) propane inhibits melanin synthesis by dual mechanisms2011
Author(s)
Niki Y, Yoshida M, Ando H, Wakamatsu K, Ito S, Harada N, Matsui M, Yarosh D, Ichihashi M.
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Journal Title
Journal of Dermatological Science
Volume: Vol.63
Pages: 115-121
Related Report
Peer Reviewed
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[Journal Article] 1-(2,4-Dihydroxyphenyl)-3-(2,4-dimethoxy-3-methylphenyl) propane inhibits melanin synthesis by dual mechanism2011
Author(s)
Niki, Y., Yoshida, M., Ando, H., Wakamatsu, K., et al
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Journal Title
J.Dermatol.Sci.
Volume: 63
Pages: 115-121
DOI
Related Report
Peer Reviewed
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[Journal Article] β-catenin regulates melanocyte dendricity through the modulation of PKCζand PKCδ2010
Author(s)
Kim J, Sohn K, Choi T, Kim M, Ando H, Choi S, Kim S, Lee Y, Lee J, Kim C, Yoon T.
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Journal Title
Pigment Cell and Melanoma Research
Volume: Vol.23
Pages: 385-393
Related Report
Peer Reviewed
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