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Elucidation of functionality of equol-producing bacteria

Research Project

Project/Area Number 21580168
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Food science
Research InstitutionNational Agriculture and Food Research Organization

Principal Investigator

TAMURA Motoi  独立行政法人農業・食品産業技術総合研究機構, 食品総合研究所・食品機能研究領域, 上席研究員 (70353943)

Co-Investigator(Kenkyū-buntansha) NAKAGAWA Hiroyuki  独立行政法人農業・食品産業技術総合研究機構, 食品総合研究所・食品安全研究領域, 主任研究員 (30308192)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsエコール / 腸内フローラ / ダイゼイン / エストロゲン / マウス / β-エストロラジオール / エストロン / 脂質代謝 / βエストラジオール
Research Abstract

Equol is a metabolite of daidzein that is produced by the intestinal flora in the gut. Life style disease prevention of equol has been expected. In our research, In in vitro anaerobic incubation of equol-producing bacteria with estriol, estrone, andβ-estradiol, we firstly elucidated that equol-producing bacteria strongly converted estrone toβ-estradiol. Administration of equol-producing bacteria to mice fed the 0.05%-daidzein-10% lard diet affected the lipid metabolism and fecal bile acid concentration. The urinary amounts ofβ-estradiol were significantly lower in the mice administrated of equol-producing bacteria than in the mice administrated of physiological saline.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (12 results)

All 2011 2010 2009

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (3 results) Book (2 results)

  • [Journal Article] Lactobacillus rhamnosus JCM 2771 : Impact on metabolism of isoflavonoids in the fecal flora from a male equol producer2011

    • Author(s)
      Tamura M, Hori S, Nakagawa H.
    • Journal Title

      Curr Microbiol

      Volume: 62(5) Pages: 1632-1637

    • URL

      http://www.springerlink.com/content/6q6607211103677m/?MUD=MP

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Apple pectin affects the efficacy of epigallocatechin gallate on oral sucrose tolerance test in adult mice2011

    • Author(s)
      Tamura M, Hori S.
    • Journal Title

      Int J Vitam Nutr Res

      Volume: 81(6) Pages: 372-377

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lactobacillus rhamnosus JCM2771 : Impact on metabolism of isoflavonoids in the fecal flora from a male equol producer.2011

    • Author(s)
      Tamura M, Hori S, Nakagawa H.
    • Journal Title

      Current Microbiology

      Volume: 62 Pages: 1632-1637

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] バイオジェニックス2010

    • Author(s)
      田村基
    • Journal Title

      日本食品科学工学会

      Volume: 57(10) Pages: 446-446

    • NAID

      130000442563

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] エクオール(equol)2010

    • Author(s)
      田村基
    • Journal Title

      日本食品科学工学会誌

      Volume: 57(11) Pages: 492-493

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lactobacillus collinoides JCM1123^T : effects on mouse plasma cholesterol and isoflavonoids in the caecum2009

    • Author(s)
      Tamura M, Hori S, Nakagawa H.
    • Journal Title

      Antonie van Leeuwenhoek

      Volume: 96(4) Pages: 621-626

    • URL

      http://www.springerlink.com/content/w261261n133n3241/?MUD=MP

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lactobacillus collinoides JCM1123T : effects on mouse plasma cholesterol and isoflavonoids in the caecum.2009

    • Author(s)
      Tamura M, Hori S, Nakagawa H.
    • Journal Title

      Antonie van Leeuwenhoek 96

      Pages: 621-626

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Impact of dihydrodaidzein-producing Clostridium-like intestinal bacterium, strain TM-40 on in vitro metabolism of daidzein by equol-producing bacterium and fecal microbiota from human2011

    • Author(s)
      Tamura M, Hori S, Kurusu Y, Nakagawa H
    • Organizer
      The Joint Meeting of the 17th International Symposium on Gnotobiology(ISG) and the 34th Congress of Society for Microbial Ecology and Disease(SOMED)
    • Place of Presentation
      ナビオス横浜
    • Year and Date
      2011-11-23
    • Related Report
      2011 Final Research Report
  • [Presentation] Impact of dihydrodaidzein-producing Clostridium-like intestinal bacterium, strain TM-40 on in vitro metabolism of daidzein by equol-producing bacterium and fecal microbiota from human2011

    • Author(s)
      田村基、堀幸子、久留主幸江、中川博之
    • Organizer
      The Joint Meeting of the 17th International Symposium on Gnotobiology (ISG) and the 34th Congress of Society for Microbial Ecology and Disease (SOMED)
    • Place of Presentation
      ナビオス横浜(神奈川県)
    • Year and Date
      2011-11-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] イソフラボン代謝と腸内細菌について2010

    • Author(s)
      田村基
    • Organizer
      Soy Nutrition Institute Japan第4回学術総会
    • Place of Presentation
      (独)国立健康・栄養研究所
    • Year and Date
      2010-02-19
    • Related Report
      2009 Annual Research Report
  • [Book] 免疫機能性食品の基礎と応用2010

    • Author(s)
      田村基、伊藤喜久治
    • Total Pages
      11
    • Publisher
      腸内フローラとその食物による変動シーエムシー出版
    • Related Report
      2011 Final Research Report
  • [Book] 免疫機能性食品の基礎と応用2010

    • Author(s)
      田村基、伊藤喜久治
    • Total Pages
      11
    • Publisher
      シーエムシー出版
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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