Chemoprevention for the microcystin-LR poisoning by natural compounds
| Project/Area Number |
21580250
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Fisheries chemistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ANDO Seiichi 名寄市立大学, 栄養学科, 教授 (80131986)
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| Co-Investigator(Renkei-kenkyūsha) |
FURUKAWA Tatsuhiko 鹿児島大学, 大学院・医歯学総合研究科, 教授 (40219100)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | マイクロシスチンLR / p53 / 肝毒性 / 発がん / OATP1B1 / OATP1B3 / 化学予防 / マイクロシスチン / セラミド / ナリンジン / トランスポーター / 肝臓毒 / 天然化合物 / カルボキシルエステラーゼ / アオコ / アポトーシス / 細胞増殖 / pifithrin-α |
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| Research Abstract |
This study demonstrates the importance of p53 in the regulation of cell fate after exposure to microcystin-LR. Our results suggest that, under conditions of p53 inactivation(including p53 mutation), chronic exposure to low doses of microcystin-LR may lead to cell proliferation through activation of Akt signaling. In addition, several compounds including naringin from grapefruit, stelliferin A from sponge, and ceramide aminoethylphosphonate from Hunboldt squid possessed the potent attenuation activity to the cytotoxicity of microcystin-LR. Results of this study may contribute to the development of chemoprevention and chemotherapeutic approaches to microcystin-LR poisoning.
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Report
(4 results)
Research Products
(63 results)
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[Journal Article] Environmental mutagens may be implicated in emergence 1 of drug-resistant microbesa2011
Author(s)
E. Miyahara, M. Nishie, S. Takumi, H. Miyanohara, J. Nishi, K. Yoshiie, H. Oda, M. Takeuchi, M. Komatsu, K. Aoyama, M. Horiuchi, and T. Takeuchi
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Journal Title
FEMS Microbiology Letters
Volume: 317
Pages: 109-116
Related Report
Peer Reviewed
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[Journal Article] Environmental mutagens may be implicated in emergence 1 of drug-resistant microbesa2011
Author(s)
E.Miyahara, M.Nishie, S.Takumi, H.Miyanohara, J.Nishi, K.Yoshiie, H.Oda, M.Takeuchi, M.Komatsu, K.Aoyama, M.Horiuchi, T.Takeuchi
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Journal Title
FEMS Microbiology Letters
Volume: 317
Issue: 2
Pages: 109-109
DOI
Related Report
Peer Reviewed
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[Journal Article] Environmental mutagens may be implicated in emergence 1 of drug-resistant microbesa2011
Author(s)
Emiko Miyahara, Makiko Nishie, Shota Takumi, Hiroaki Miyanohara, Jun-ichiro Nishi, Kiyotaka Yoshiie, Hiroshi Oda, Minoru Takeuchi, Masaharu Komatsu, Kohji Aoyama, Masahisa Horiuchi, Toru Takeuchi
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Journal Title
FEMS Microbiology Letters
Volume: (印刷中)
Related Report
Peer Reviewed
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[Journal Article] p53 plays an important role in cell fate determination after exposure to microcystin-LR2010
Author(s)
S. Takumi, M. Komatsu, T. Furukawa, R. Ikeda, T. Sumizawa, H. Akenaga, Y. Maeda, K. Aoyama, K. Arizono, S. Ando, and T. Takeuchi
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Journal Title
Environmental Health Perspectives
Volume: 118
Pages: 1292-1298
Related Report
Peer Reviewed
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[Journal Article] Cytotoxic Isomalabaricane Derivatives and a Monocytclic Triterpene Glycoside from the Sponge Rhabdastrella globostellata2010
Author(s)
M. Hirashima, K. Tsuda, T. Hamada, H. Okamura, T. Furukawa, S. Akiyama, Y. Tajitsu, R. Ikeda, M. Komatsu, M. Doe, Y. Morimoto, M. Shiro, R. W. M. van Soest, K. Takemura and T. Iwagawa
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Journal Title
Journal of Natural Products
Volume: 73
Pages: 1512-1518
Related Report
Peer Reviewed
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[Journal Article] p53 plays an important role in cell fate determination after exposure to microcystin-LR.2010
Author(s)
Shota Takumi, Masaharu Komatsu, Tatsuhiko Furukawa, Ryuji Ikeda, Tomoyuki Sumizawa, Hitomi Akenaga, Yuta Maeda, Kohji Aoyama, Koji Arizono, Seiichi Ando, Toru Takeuchi
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Journal Title
Environmental Health Perspectives
Volume: 118
Pages: 1292-1298
Related Report
Peer Reviewed
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