| Project/Area Number |
21580250
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Fisheries chemistry
|
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| Research Institution | Kagoshima University |
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Principal Investigator |
|
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| Co-Investigator(Kenkyū-buntansha) |
ANDO Seiichi 名寄市立大学, 栄養学科, 教授 (80131986)
|
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| Co-Investigator(Renkei-kenkyūsha) |
FURUKAWA Tatsuhiko 鹿児島大学, 大学院・医歯学総合研究科, 教授 (40219100)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | マイクロシスチンLR / p53 / 肝毒性 / 発がん / OATP1B1 / OATP1B3 / 化学予防 / マイクロシスチン / セラミド / ナリンジン / トランスポーター / 肝臓毒 / 天然化合物 / カルボキシルエステラーゼ / アオコ / アポトーシス / 細胞増殖 / pifithrin-α |
|---|
| Research Abstract |
This study demonstrates the importance of p53 in the regulation of cell fate after exposure to microcystin-LR. Our results suggest that, under conditions of p53 inactivation(including p53 mutation), chronic exposure to low doses of microcystin-LR may lead to cell proliferation through activation of Akt signaling. In addition, several compounds including naringin from grapefruit, stelliferin A from sponge, and ceramide aminoethylphosphonate from Hunboldt squid possessed the potent attenuation activity to the cytotoxicity of microcystin-LR. Results of this study may contribute to the development of chemoprevention and chemotherapeutic approaches to microcystin-LR poisoning.
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