Effects of placental transfer of phytoestrogen on physiological function in mammals

• Project/Area Number: 21580328
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Zootechnical science/Grassland science
• Research Institution: Kyoto University
• Principal Investigator: KUME Shinichi 京都大学, 大学院・農学研究科, 教授 (90355454)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 植物エストロゲン / 新生仔マウス / 胎盤 / 哺乳動物 / 腸管免疫 / カルシウム代謝 / エストロゲン受容体

Research Abstract

Coumestrol administration decreases the ALP activity in intestine of pregnant mice and increases the numbers of IgA-secreting cells in mammary gland of lactating mice. Coumestrol administration to maternal mice during pregnancy and lactation affects renal Ca metabolism in neonatal mice, especially male neonatal mice via maternal milk. Phytoestrogens may act as both estrogen agonists and antagonists through estrogen receptor.

Research Products

• [Journal Article] Effects of bisphenol A administration to pregnant mice on serum Ca and intestinal Ca absorption (2012)
  • Author(s): Otsuka H, Sugimoto M, Ikeda S, Kume S.
  • Journal Title: Animal Science Journal Volume: 83 Issue: 3 Pages: 232-237
  • DOI: 10.1111/j.1740-0929.2011.00947.x
  • Peer Reviewed
• [Journal Article] Effects of coumestrol administration to maternal mice during pregnancy and lactation on renal Ca metabolism in neonatal mice (2011)
  • Author(s): Ueda M, Horiguchi Y, Sugimoto M, Ikeda S, Kume S.
  • Journal Title: Animal Science Journal Volume: (Web掲載) Issue: 6 Pages: 1-5
  • DOI: 10.1111/j.1740-0929.2011.00977.x
  • Peer Reviewed
• [Journal Article] Effects of coumestrol administration to pregnant and lactating mice on intestinal alkaline phosphatase activit (2011)
  • Author(s): Kirihata Y, Horiguchi Y, Ueda M, Sugimoto M, Ikeda S, Kume S.
  • Journal Title: Phytotherapy Research Volume: 25 Issue: 5 Pages: 654-658
  • DOI: 10.1002/ptr.3317
  • Peer Reviewed
• [Journal Article] 高泌乳牛の移行期の特徴と移行期におけるミネラル代謝の改善 (2011)
  • Author(s): 久米新一・宿院亨・北村祐太
  • Journal Title: 畜産の研究 Volume: 65 Pages: 793-803
  • NAID: 40018931316
• [Journal Article] Effects of Coumestrol Administration to Pregnant and Lactating Mice on Intestinal Alkaline Phosphatase Activity. (2010)
  • Author(s): Kirihata Y, Horiguchi Y, Ueda M, Sugimoto M, Ikeda S, Kume S
  • Journal Title: Phytotherapy Research Volume: (Online掲載)
  • NAID: 120005593600
  • Peer Reviewed
• [Presentation] 泌乳マウスの乳腺におけるIgA産生に及ぼすクメステロール投与の影響 (2011)
  • Author(s): 王蒙東・杉本実紀・池田俊太郎・久米新一
  • Organizer: 第61回関西畜産学会大会
  • Place of Presentation: 岡山大学
  • Year and Date: 2011-09-13
• [Presentation] Effects of Coumestrol Administration for Maternal Mice during Pregnancy on Ca Metabolism in Neonatal Mice (2010)
  • Author(s): Ueda M, Sugimoto M, Ikeda S, Kume S
  • Organizer: The 14th Animal Science Congress of the Asian-Australasian Association of Animal Production Societies
  • Place of Presentation: 台湾・高雄
  • Year and Date: 2010-08-26
• [Presentation] Effects of coumestrol administration for maternal mice during pregnancy on Ca metabolism in neonatal mice (2010)
  • Author(s): Ueda M, Sugimoto M, Ikeda S, Kume S.
  • Organizer: The 14th Animal Science Congress of the Asian-Australasian Association of Animal Production Societies
  • Place of Presentation: 台湾・高雄
  • Year and Date: 2010-08-22
• [Presentation] 新生仔マウスのカルシウム代謝に及ぼすクメステロール投与の影響 (2009)
  • Author(s): 上田道久・堀口善裕・池田俊太郎・杉本実紀・久米新一
  • Organizer: 第59回関西畜産学会大会
  • Place of Presentation: 鳥取大学
  • Year and Date: 2009-08-28
• [Presentation] 新生仔マウスのカルシウム代謝に及ぼすクメステロールの影響 (2009)
  • Author(s): 上田道久・堀口善広・池田俊太郎・杉本実紀・久米新一
  • Organizer: 第59回関西畜産学会大会
  • Place of Presentation: 鳥取大学
  • Year and Date: 2009-08-28