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Basic research on development of functional cheese. Antioxidant ingredients of cheese and their structure

Research Project

Project/Area Number 21580337
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Zootechnical science/Grassland science
Research InstitutionTokai University

Principal Investigator

IGOSHI Keiji  東海大学, 農学部, 教授 (80148973)

Co-Investigator(Renkei-kenkyūsha) YASUDA Shin  東海大学, 農学部, 講師 (10512923)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywordsチーズ / 機能性 / 抗酸化 / ペプチド / ホゲンチジン酸 / ホモプロトカテク酸 / DPPHラジカル消去 / ホモゲンチジ / 抗酸化活性 / ラジカル消去活性 / 機能性チーズ / ポリフェノール / ブルーチーズ / Pen.roqueforti / アスパラギン酸プロテアーゼ / DPPHラジカル消去活性 / 尿酸 / CPP / Penicillium roqueforti / メタルプロテアーゼ
Research Abstract

Antioxidant activity and the structure of high-active ingredients in commercial cheeses were studied for development of functional cheese which can decrease oxidative stress. Antioxdant activities were observed in most of ripened cheeses, except of non-ripened cheeses. High activity was especially observed in Blue, Stilton, Epoisses, Pont-l' Eveque, Camembert and Brie cheese. The antioxidant ingredients were purified and isolated from the Blue cheese, and the structure of them was clarified. Consequently, the antioxidant peptides and also the polyphenols such as the homogentisic acid and the homoprotocatechuic acid were identified from the Blue cheese.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (18 results)

All 2012 2011 2010 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (11 results) Remarks (1 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] 市販ヤギ乳チーズの過酸化水素およびスーパーオキシドアニオンラジカルに対する消去作用2012

    • Author(s)
      河本佳奈江、井越敬司、門岡幸男、小林弘昌、安田伸
    • Journal Title

      東海大学紀要

      Volume: 31 Pages: 31-38

    • NAID

      40019205020

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of highly ripened cheeses in HL-60 human leukemia cells : Antiproliferative activity and induction of apoptotic DNA damage2010

    • Author(s)
      Shin Yasuda, Yukio Kadokoka, Keiji Igoshi(員数9名、9番目)
    • Journal Title

      Journal of Dairy Science

      Volume: 93 Pages: 1393-1400

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of highly ripened cheeses in HL-60 human leukemia cells : Antiproliferative activity and induction of apoptotic DNA damage.2010

    • Author(s)
      Shin.Yasuda
    • Journal Title

      Journal of Dairy Science

      Volume: VOL93 Pages: 1393-1400

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] ブルーチーズ熟成中に生成されるDPPHラジカル消去成分2012

    • Author(s)
      井越敬司
    • Organizer
      日本畜産学会
    • Place of Presentation
      名古屋大学
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 機能性チーズ創製のための基盤研究-チーズの機能性成分-2012

    • Author(s)
      井越敬司
    • Organizer
      日本畜産学会
    • Place of Presentation
      名古屋大学
    • Year and Date
      2012-03-29
    • Related Report
      2011 Final Research Report
  • [Presentation] 機能性チーズ創製の基盤研究-チーズの抗酸化成分-2012

    • Author(s)
      井越敬司
    • Organizer
      日本畜産学会
    • Place of Presentation
      名古屋大学(招待講演)
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] ブルータイプチーズ熟成中のDPPHラジカル消去活性2012

    • Author(s)
      井越敬司
    • Organizer
      熊本県産学官技術交流会実行委員会
    • Place of Presentation
      熊本県産業技術センター
    • Year and Date
      2012-01-18
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Penicillium roqueforti BSの脱脂乳培養過程中におけるミルクタンパク質の分解と抗酸化活性2010

    • Author(s)
      井越敬司
    • Organizer
      日本栄養・食糧学会九州・沖縄支部
    • Place of Presentation
      宮崎観光ホテル(宮崎)
    • Year and Date
      2010-09-25
    • Related Report
      2011 Final Research Report
  • [Presentation] Penicillium roqueforti Bsの脱脂乳培養過程中におけるミルクタンパク質の分解と抗酸化活性2010

    • Author(s)
      井越敬司
    • Organizer
      日本栄養・食糧学会九州・沖縄支部
    • Place of Presentation
      宮崎観光ホテル(宮崎)
    • Year and Date
      2010-09-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] ブルーチーズ中に含まれるDPPHラジカル消去成分について2010

    • Author(s)
      井越敬司
    • Organizer
      日本農芸化学西日本支部
    • Place of Presentation
      崇城大学(熊本)
    • Year and Date
      2010-09-18
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 各種チーズのDPPHラジカル消去活性の比較2010

    • Author(s)
      井越敬司
    • Organizer
      日本農芸化学西日本支部
    • Place of Presentation
      崇城大学(熊本)
    • Year and Date
      2010-09-18
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] チーズのビフィズス菌増殖活性とその成分2010

    • Author(s)
      井越敬司
    • Organizer
      日本酪農科学会
    • Place of Presentation
      共立女子大学(東京)
    • Year and Date
      2010-08-20
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Penicillium roquefortiの菌体外プロティナーゼの精製と性質2010

    • Author(s)
      井越敬司
    • Organizer
      日本畜産学会
    • Place of Presentation
      明治大学駿河台校舎キャンパス(東京)
    • Year and Date
      2010-03-28
    • Related Report
      2011 Final Research Report
  • [Presentation] Penicillium roquefortiの菌体外プロティナーゼの精製と性質2010

    • Author(s)
      井越敬司
    • Organizer
      日本畜産学会
    • Place of Presentation
      東京都明治大学駿河台校舎キャンパス
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] ペプチド2011

    • Inventor(s)
      井越敬司、川上浩、元賣睦美
    • Industrial Property Rights Holder
      学校法人東海大学、雪印メグミルク
    • Industrial Property Number
      2011-218853
    • Filing Date
      2011-10-03
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] ペプチド2011

    • Inventor(s)
      井越敬司、川上浩、元賣睦美
    • Industrial Property Rights Holder
      学校法人東海大学、雪印メグミルク(株)
    • Acquisition Date
      2011-10-21
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] ペプチド2011

    • Inventor(s)
      井越敬司
    • Industrial Property Rights Holder
      東海大学
    • Industrial Property Number
      2011-218853
    • Filing Date
      2011-10-03
    • Related Report
      2011 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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