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Morpho-functional relationship between myostatin and muscle spindle in bovine skeletal muscles.

Research Project

Project/Area Number 21580341
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied animal science
Research InstitutionTohoku University

Principal Investigator

WATANABE Kouichi  東北大学, 大学院・農学研究科, 助教 (80261494)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords筋線維型 / 筋紡錘 / ミオスタチン / 筋運動制御 / ウシ / 筋小胞体カルシウムポンプ / カルパイン
Research Abstract

Morpho-functional relationship between myostatin and muscle spindle was investigated in bovine skeletal muscles, using double-muscled cattle"Grass-field shorthorn". Though this study was stricken seriously by the Great East Japan Earthquake, we found that slow muscles contained many type I myofibers exhibited lower expression of myostatin than fast muscle did. Furthermore our results suggested that a calcium ion signaling in myofiber might play a crucial role in myofiber type fast-to-slow transformation.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (29 results)

All 2012 2011 2010 2009 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (21 results) Book (1 results) Remarks (3 results)

  • [Journal Article] TIEG1 negatively controls the myoblast pool indispensable for fusion during myogenic differentiation of C2C12 cells2011

    • Author(s)
      Miyake M. Hayashi S., Iwasaki S., Uchida T., Watanabe K, Ohwada S., aso H., Yamaguchi T.
    • Journal Title

      Journal of Cellular Physiology

      Volume: 226-4巻 Pages: 1128-1136

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] TIEG1 negatively controls the myoblast pool indispensable for fusion during myogenic differentiation of C2C12 cells2011

    • Author(s)
      Miyake M.Hayashi S., Iwasaki S., Uchida T., Watanabe K, Ohwada S., Aso H., Yamaguchi T.
    • Journal Title

      Journal of Cellular Physiology

      Volume: 226 Pages: 1128-1136

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Myostatin down-regulates the IGF-2 expression via ALK-Smad signaling during myogenesis in cattle2009

    • Author(s)
      Miyake M., Hayashi S., Taketa Y., Iwasaki S., Watanabe K., Ohwada S., Aso H., Yamaguchi T.
    • Journal Title

      Animal Science Journal

      Volume: 81-2巻 Pages: 223-229

    • NAID

      10030374166

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Myostatin down-regulates the IGF-2 expression via ALK-Smad signaling during myogenesis in cattle2009

    • Author(s)
      Miyake M.
    • Journal Title

      Animal Science Journal 81

      Pages: 223-229

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] ウシ骨格筋筋線維型に依存した筋衛星細胞のミオスタチン発現2012

    • Author(s)
      北川絵理・三宅雅人・高橋秀之・櫻田隆大・白須直樹・渡邊康一・大和田修一・麻生久
    • Organizer
      第115回日本畜産学会大会
    • Place of Presentation
      名古屋大学東山キャンパス
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 筋線維型移行モデルにおける筋線維新生誘導2012

    • Author(s)
      櫻田隆大・白須直樹・北川絵理・大和田修一・山口高弘・麻生久・渡邊康一
    • Organizer
      第115回日本畜産学会大会
    • Place of Presentation
      名古屋大学東山キャンパス
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 放牧期の日本短角種および肉用交雑種における筋線維型移行と血液性状2012

    • Author(s)
      小笠原英毅・畔柳正・北川絵理・渡邊康一・渡邉一史・高橋秀之・小野泰・大和田修一・麻生久・寳示戸雅之
    • Organizer
      第115回日本畜産学会大会
    • Place of Presentation
      名古屋大学東山キャンパス
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 新たな肉用牛資源としての草原短角牛の産肉能力2011

    • Author(s)
      渡邊康一
    • Organizer
      東北大学農学研究科先端農学研究センター第25回先端農学セミナー(招待講演)
    • Place of Presentation
      東北大学大学院農学研究科
    • Year and Date
      2011-11-24
    • Related Report
      2011 Final Research Report
  • [Presentation] 新たな肉用牛資源としての草原短角牛の産肉能力2011

    • Author(s)
      渡邊康一
    • Organizer
      東北大学農学研究科先端農学研究センター第25回先端農学セミナー
    • Place of Presentation
      東北大学大学院農学研究科(招待講演)
    • Year and Date
      2011-11-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 粗飼料多給肥育による草原短角牛の肉質特性2011

    • Author(s)
      佐藤裕尚・岩月俊樹・内田江一朗・渡邊康一・麻生久・山口高弘
    • Organizer
      第49回肉用牛研究会
    • Place of Presentation
      山形県山形市
    • Year and Date
      2011-11-17
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] ウシ骨格筋線維型における筋小胞体カルシウムイオンポンプの発現様式2011

    • Author(s)
      櫻田隆大・白須直樹・北川絵理・三宅雅人・大和田修一・山口高弘・麻生久・渡邊康一
    • Organizer
      第61回東北畜産学会
    • Place of Presentation
      青森県青森市
    • Year and Date
      2011-09-09
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 放牧など自給粗飼料100%で生産した日本短角種および北里八雲牛の枝肉成績と筋線維型構成2011

    • Author(s)
      小笠原英毅・畔柳正・米澤智洋・渡邊康一・三宅雅人・高橋秀之・小野泰・大和田修一・麻生久・山口高弘・寳示戸雅之
    • Organizer
      第114回日本畜産学会大会
    • Place of Presentation
      北里大学獣医学部
    • Year and Date
      2011-08-27
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 末梢セロトニンの骨格筋におけるエネルギー代謝亢進作用2011

    • Author(s)
      中野辰也・渡邉一史・齋藤和輝・齋藤遼・高橋遊・長澤裕哉・井上奈穂・池田郁男・大和田修一・渡邊康一・山口高弘・麻生久
    • Organizer
      第114回日本畜産学会大会
    • Place of Presentation
      北里大学獣医学部
    • Year and Date
      2011-08-26
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 国内外における赤身牛肉の評価の実情について2011

    • Author(s)
      渡邊康一
    • Organizer
      日本産肉研究会第8回学術集会(指名講演)
    • Place of Presentation
      北里大学獣医学部
    • Year and Date
      2011-08-24
    • Related Report
      2011 Final Research Report
  • [Presentation] 国内外における赤身牛肉の評価の実情について2011

    • Author(s)
      渡邊康一
    • Organizer
      日本産肉研究会第8回学術集会
    • Place of Presentation
      北里大学獣医学部(招待講演)
    • Year and Date
      2011-08-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] Early adaptation of sarcoplasmic reticulum Ca2+ pump in bovine myofiber under chronic low-frequency electrical stimulation2011

    • Author(s)
      Sakurada T., Kitagawa E., Miyake M., Ohwada S., Aso H., Watanabe K.
    • Organizer
      ADSA-ASAS 2011 Joint Annual Meeting
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2011-07-14
    • Related Report
      2011 Final Research Report
  • [Presentation] Early adaptation of sarcoplasmic reticulum Ca^<2+> pump in bovine myofiber under chronic low-frequency electrical stimulation2011

    • Author(s)
      Sakurada T., Kitagawa E., Miyake M., Ohwada S., Aso H., Watanabe K.
    • Organizer
      ADSA-ASAS 2011 Joint Annual Meeting
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2011-07-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] 牛骨格筋における筋衛星細胞の分布と挙動2010

    • Author(s)
      北川絵理、三宅雅人、今井由佳、岩崎俊輔、渡邊康一、大和田修一、麻生久、山口高弘
    • Organizer
      第60回東北畜産学会大会
    • Place of Presentation
      岩手県盛岡市
    • Year and Date
      2010-08-30
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 血小板由来セロトニンの骨格筋再生に及ぼす影響2010

    • Author(s)
      巣国正、三宅雅人、渡邉一史、北川絵理、中野辰也、高橋遊、大和田修一、渡邊康一、麻生久、山口高弘
    • Organizer
      第60回東北畜産学会大会
    • Place of Presentation
      岩手県盛岡市
    • Year and Date
      2010-08-30
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 牛肉としての骨格筋2010

    • Author(s)
      渡邊康一
    • Organizer
      日本産肉研究会第6回学術集会(招待講演)
    • Place of Presentation
      明治大学駿河台キャンパス
    • Year and Date
      2010-03-30
    • Related Report
      2011 Final Research Report
  • [Presentation] 牛肉としての骨格筋2010

    • Author(s)
      渡邊康一
    • Organizer
      日本産肉研究会第6回学術集会
    • Place of Presentation
      明治大学駿河台キャンパス
    • Year and Date
      2010-03-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] ウシ筋線維型におけるマイオスタチンmRNAの発現2010

    • Author(s)
      北川絵理・三宅雅人・高橋秀之・岩崎俊輔・渡邊康一・大和田修一・麻生久・山口高弘
    • Organizer
      日本畜産学会第111回大会
    • Place of Presentation
      明治大学駿河台キャンパス
    • Year and Date
      2010-03-29
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] 放牧飼養下におけるウシ腰最長筋中の筋機能関連因子mRNA発現動態2010

    • Author(s)
      木戸恭子・池田哲也・三宅雅人・北川絵里・渡邊康一・山口高弘
    • Organizer
      日本畜産学会第111回大会
    • Place of Presentation
      明治大学駿河台キャンパス
    • Year and Date
      2010-03-29
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] 放牧など自給粗飼料100%で生産した肥育牛の筋線維型構成2010

    • Author(s)
      小笠原英毅・畔柳正・渡邊康一・三宅雅人・岩崎俊輔・大和田修一・麻生久・山口高弘・萬田富治
    • Organizer
      日本畜産学会第111回大会
    • Place of Presentation
      明治大学駿河台キャンパス
    • Year and Date
      2010-03-29
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] Perspective of beef production in Japan and studies on muscle biology2009

    • Author(s)
      Watanabe K
    • Organizer
      China-Japan joint Seminar : Improvement of beef production and beef quality
    • Place of Presentation
      Beijing, China
    • Year and Date
      2009-10-10
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Book] 獣医組織学第5版2011

    • Author(s)
      山口高弘、渡邊康一
    • Publisher
      学窓社
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.agri.tohoku.ac.jp/keitai/index-j.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.agri.tohoku.ac.jp/keitai/index-j.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.agri.tohoku.ac.jp/keitai/index-j.html

    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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