Investigation for physiological roles of glucocorticoid in the periovulatory follicle
| Project/Area Number |
21580357
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Obihiro University of Agriculture and Veterinary Medicine |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 排卵 / 炎症 / 糖質コルチコイド / サイトカイン / 卵母細胞 / 11β-HSD / 糖質コルチコイド受容体 / 生理学 / 細胞・組織 / 酵素 |
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| Research Abstract |
Ovulation in mammal is an inflammatory reaction and the oocyte undergoes this process is likely to be influenced by various inflammatory factors. In this study we investigated the presence and action of enzymes that catalyze anti-inflammatory glucocorticoid (G) and inflammatory cytokine IL-1 in the bovine cumulus-oocyte complex (COC). Expression and action of enzymes that activate/inactivate G as well as IL-1 and its functional receptor are demonstrated in COC. These results suggest that G and IL-1 act together to regulate functions of periovulatory bovine COC.
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Report
(4 results)
Research Products
(12 results)
