Study on the prion protein functions and tumor control
| Project/Area Number |
21580361
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Kobe University |
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Principal Investigator |
SAEKI Keiichi 神戸大学, 農学研究科, 准教授 (10311630)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKEYAMA Natsumi 財団法人日本生物科学研究所 (20414089)
KUSAKABE Moriaki 東京大学, 農学生命科学研究科, 特任教授 (60153277)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 生理 / プリオン蛋白 / プリオン蛋白遺伝子 / 腫瘍 / 腫瘍細胞 / 遺伝子発現 / ヌードマウス / 移植腫瘍 / テネイシンC |
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| Research Abstract |
To understand the physiological function of prion protein(PrP), the expression level of PrP gene was investigated using various tumors transplanted in the nude mouse and tenascin C deficient nude mouse, respectively. PrP gene expression levels were varied in the implanted cancer cells. This study provided the information necessary to elucidate a link between PrP function and cancer cell surviving.
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Report
(4 results)
Research Products
(2 results)
