Study on the prion protein functions and tumor control

• Project/Area Number: 21580361
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Basic veterinary science/Basic zootechnical science
• Research Institution: Kobe University
• Principal Investigator: SAEKI Keiichi 神戸大学, 農学研究科, 准教授 (10311630)
• Co-Investigator(Renkei-kenkyūsha): TAKEYAMA Natsumi 財団法人日本生物科学研究所 (20414089) ; KUSAKABE Moriaki 東京大学, 農学生命科学研究科, 特任教授 (60153277)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 生理 / プリオン蛋白 / プリオン蛋白遺伝子 / 腫瘍 / 腫瘍細胞 / 遺伝子発現 / ヌードマウス / 移植腫瘍 / テネイシンC

Research Abstract

To understand the physiological function of prion protein(PrP), the expression level of PrP gene was investigated using various tumors transplanted in the nude mouse and tenascin C deficient nude mouse, respectively. PrP gene expression levels were varied in the implanted cancer cells. This study provided the information necessary to elucidate a link between PrP function and cancer cell surviving.

Research Products

• [Presentation] 腫瘍組織におけるプリオン蛋白(PrP)遺伝子発現量の比較 (2010)
  • Author(s): 山崎智宏
  • Organizer: 日本獣医学会
  • Place of Presentation: 帯広畜産大学(北海道)
  • Year and Date: 2010-09-16
• [Presentation] 腫瘍組織におけるプリオン蛋白(PrP)遺伝子発現量み比較 (2010)
  • Author(s): 山崎智宏
  • Organizer: 日本獣医学会
  • Place of Presentation: 帯広畜産大学(北海道)
  • Year and Date: 2010-09-16