Destruction of niche and target-cells in autoimmune diseases by effector cells and molecules

• Project/Area Number: 21580362
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Basic veterinary science/Basic zootechnical science
• Research Institution: Yamaguchi University
• Principal Investigator: HAYASHI Toshiharu 山口大学, 農学部, 教授 (90111484)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 自己免疫疾患 / 1型糖尿病 / 全身性エリテマトーデス / シェーグレン症候群 / モデル / アレルギー性喘息 / 病理発生 / Niche / 遺伝子治療 / インターフェロンγ / ループス / 喘息 / 遅発型 / 腸 / 好酸球性血管炎 / 概念 / 環境因子 / 自己寛容 / メカニズム / β細胞

Research Abstract

One might expect that effector cells(and/ or effector molecules) encounter firstly micro-environmental component(niche) before the destruction of target-cells in autoimmune diseases. However, there is a little attention of destruction of niche morphologically and functionally in the pathogenesis in immune diseases. During the analysis of autoimmune diseases the importance of niche concept in the pathogenesis of autoimmune diseases was clarified.

Research Products

• [Journal Article] Destruction of salivary and lacrimal glands by T1 polarized reaction in a model of secondary Sjogren' s Syndrome in lupus-prone female NZB_xNZWF_1 mice. (2011)
  • Author(s): Hayashi T, Shimoyama N, Mizuno T.
  • Journal Title: Inflammation Volume: (In press) Issue: 2 Pages: 638-646
  • DOI: 10.1007/s10753-011-9356-y
  • Peer Reviewed
• [Journal Article] Dysfunction of lacrimal and salivary glands in Sjogren' s syndrome : non-immunologic injury in pre-inflammatory phase and mouse (2011)
  • Author(s): Hayashi T.
  • Journal Title: J Biomed Biotech Volume: 2011 Issue: 1
  • DOI: 10.1155/2011/407031
  • Peer Reviewed
• [Journal Article] Eosinophilic venulitis of intestine in a mouse model of late allergic rhinitis (2011)
  • Author(s): Linh BK, Hayashi T, Nakasima T, T. Horii Y.
  • Journal Title: Inflammation Volume: 34 Pages: 499-508
  • Peer Reviewed
• [Journal Article] Immunopathogenesis of distant manifestation in effector phase after a local airway allergy (2011)
  • Author(s): Hayashi T.
  • Journal Title: Research Trends Volume: 12 Pages: 67-76
• [Journal Article] Eosinophilic venulitis in intestines in a mouse model of late asthma (2011)
  • Author(s): Linh BK, et al
  • Journal Title: Inflammation Volume: 34 Pages: 499-508
  • Peer Reviewed
• [Journal Article] Therapeutic strategies for SLE involving cytokines : mechanism-oriented therapies especially IFN-γtargeting gene therapy (2010)
  • Author(s): Hayashi T.
  • Journal Title: J Biomed Biotech Volume: 2010 Pages: 1-19
  • DOI: 10.1155/2010/461641
  • Peer Reviewed
• [Journal Article] Therapeutic strategies for SLE involving cytokines : mechanism-oriented therapies especially IFN-γ targeting gene therapy (2010)
  • Author(s): Hayashi, T.
  • Journal Title: J.Biomed.Biotech.
  • Peer Reviewed
• [Journal Article] Eosinophilic venulitis in the small intestines in a mouse model of late asthma (2010)
  • Author(s): Linh, B.K., Hayashi, T., Nakasima, T., T.Horiii
  • Journal Title: Inflammation
  • Peer Reviewed
• [Book] Molecular mechanisms in allergic rhinitis : modulation by microbes, In : Advances in Medicine and Biology (2012)
  • Author(s): Hayashi T.
• [Book] In : Handbook of Type1 Diabetes Mellitus (2010)
  • Author(s): Hayashi T.
  • Publisher: Environmental factors and concepts in the induction of type 1 diabetes
• [Book] Environmental factors and concepts in the induction of type 1 diabetes (2010)
  • Author(s): Toshiharu Hayashi
  • Total Pages: 46
  • Publisher: Nova Science Publisheres, Inc.