The relationship of collagen fiber content and hepatic stellate cell function in the liver.

• Project/Area Number: 21580364
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Basic veterinary science/Basic zootechnical science
• Research Institution: Kyushu University
• Principal Investigator: NISHIMURA Shotaro 九州大学, 大学院・農学研究院, 准教授 (70237725)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: 肝臓 / 肝星細胞 / コラーゲン線維 / ニワトリ / 免疫組織化学 / コラーゲン

Research Abstract

This study was performed to clarify the relationship of the collagen fiber content and the characteristics of hepatic stellate cells(HSCs) in the chicken liver. The collagen fiber content, distribution and activity of HSCs in the liver were larger in cocks than in hens. These differences between the sexes were not observed during the embryonic stage and confirmed at 8 weeks of age of post-hatching stage. It is suggested that estradiol may be affected to inhibit the collagen fiber synthesis in the HSCs in the female chicken liver.

Research Products

• [Journal Article] Changes in collagen fiber content and hepatic stellate cell distribution in the liver of chick embryos and growing chickens (2012)
  • Author(s): Nishimura, et al
  • Journal Title: Animal Science Journal Volume: (In press) Issue: 6 Pages: 499-503
  • DOI: 10.1111/j.1740-0929.2011.00986.x
  • Peer Reviewed
• [Journal Article] The comparison of the collagen fiber contents and hepatic stellate cell distribution in male and female chicken livers (2011)
  • Author(s): Nishimura, S., A. Sagara, A. Teshima and S. Tabata
  • Journal Title: Animal Science Journal Volume: 82 Pages: 759-763
  • NAID: 10030566866
• [Journal Article] The comparison of the collagen fiber contents and hepatic stellate cell distribution in male and female chicken livers (2011)
  • Author(s): Nishimura, et al.
  • Journal Title: Animal Science Journal Volume: (印刷中)
  • NAID: 10030566866
  • Peer Reviewed
• [Journal Article] Immunohistochemical and scanning electron microscopic comparison of the collagen network constructions between pig, goat and chicken livers (2009)
  • Author(s): Nishimura, S., A. Sagara, I. Oshima, Y. Ono, H. Iwamoto, K. Okano, H. Miyachi and S. Tabata
  • Journal Title: Animal Science Journal Volume: 80 Pages: 451-459
  • NAID: 10027887119
• [Journal Article] Immunohistochemical and scanning electron microscopic comparison of the collagen network constructions between pig, goat and chicken livers (2009)
  • Author(s): Nishimura, et al.
  • Journal Title: Animal Science Journal 80 Pages: 451-459
  • NAID: 10027887119
  • Peer Reviewed
• [Journal Article] Changes in collagen fiber content and hepatic stellate cell distribution in the liver of chick embryos and growing chickens
  • Author(s): Nishimura, S., A. Teshima, V. S. Chowdhury and S. Tabata
  • Journal Title: Animal Science Journal, in press
• [Presentation] The influence of different nutritional feeding on the histological properties of the liver in the Japanese Black steers-An evaluation using cloned animals- (2011)
  • Author(s): Nishimura, et al
  • Organizer: The 8th International AFAS Joint Symposium between Japan and Korea
  • Place of Presentation: Yonago, Japan
  • Year and Date: 2011-11-16
• [Presentation] 異なる栄養条件が黒毛和種クローン去勢雄牛の肝臓の組織特性に及ぼす影響 (2011)
  • Author(s): 西村正太郎, ら
  • Organizer: 第4回日本暖地畜産学会沖縄大会
  • Place of Presentation: 沖縄産業支援センター(沖縄)
  • Year and Date: 2011-10-30
• [Presentation] ブロイラー肝臓のコラーゲン線維量と肝星細胞分布における雌雄差の出現とその要因について (2011)
  • Author(s): 西村正太郎, ら
  • Organizer: 日本畜産学会第114回大会
  • Place of Presentation: 北里大学(青森)
  • Year and Date: 2011-08-27
• [Presentation] 異なる栄養条件が黒毛和種クローン去勢雄牛の肝臓の組織特性に及ぼす影響 (2011)
  • Author(s): 西村正太郎・手島彰文・藤村亮佑・衛藤哲次・塩塚雄二・江原史雄・松田謙一郎・藤田達男・阿比留真吾・田畑正志・後藤貴文
  • Organizer: 第4回日本暖地畜産学会沖縄大会
• [Presentation] ブロイラー肝臓のコラーゲン線維量と肝星細胞分布における雌雄差の出現とその要因について (2011)
  • Author(s): 西村正太郎・舩津哲・手島彰文・宮地秀行・田畑正志
  • Organizer: 日本畜産学会第114回大会
• [Presentation] 初期成長過程におけるニワトリ肝臓のコラーゲン線維量の変化と肝星細胞の分布について (2010)
  • Author(s): 西村正太郎・手島彰文・田畑正志
  • Organizer: 第3回日本暖地畜産学会大分大会
• [Presentation] 胚発生過程におけるニワトリ肝臓のコラーゲン線維網の発達と肝星細胞の分布について (2010)
  • Author(s): 手島彰文・西村正太郎・田畑正志
  • Organizer: 日本家禽学会2010年度秋季大会
• [Presentation] 肝臓コラーゲン線維網を用いたニワトリ腺性下垂体単離細胞の三次元培養の試み (2009)
  • Author(s): 西村正太郎, 他
  • Organizer: 第34回鳥類内分泌研究会
  • Place of Presentation: 札幌市・定山渓グランドホテル
  • Year and Date: 2009-11-14
• [Presentation] ブロイラーの脂肪肝におけるコラーゲン線維含量および肝星細胞の分布密度 (2009)
  • Author(s): 西村正太郎, 他
  • Organizer: 第2回日本暖地畜産学会長崎大会
  • Place of Presentation: 長崎大学
  • Year and Date: 2009-10-25
• [Presentation] 胚発生期におけるニワトリ肝臓内コラーゲン線維の発達についての検討 (2009)
  • Author(s): 手島彰文, 他
  • Organizer: 日本畜産学会第111回大会
  • Place of Presentation: 琉球大学
  • Year and Date: 2009-09-29
• [Presentation] 肝臓コラーゲン線維網を用いたニワトリ腺性下垂体単離細胞の三次元培養の試み (2009)
  • Author(s): 酉村正太郎・田畑正志
  • Organizer: 第34回鳥類内分泌研究会
• [Presentation] ブロイラーの脂肪肝におけるコラーゲン線維含量および肝星細胞の分布密度 (2009)
  • Author(s): 西村正太郎・相良彩乃・手島彰文・宮地秀行・田畑正志
  • Organizer: 第2回日本暖地畜産学会長崎大会
• [Presentation] 胚発生期におけるニワトリ肝臓内コラーゲン線維の発達についての検討 (2009)
  • Author(s): 手島彰文・西村正太郎・宮地秀行・田畑正志
  • Organizer: 日本畜産学会第111回大会
• [Presentation] The Influence of Different Nutritional Feeding on the Histological Properties of the Liver in the Japanese Black Steers.-An Evaluation Using Cloned Animals-
  • Author(s): Nishimura S., A. Teshima, R. Fujimura, T. Etoh, Y. Shiotsuka, F. Ebara, K. Matsuda, T. Fujita, S. Abiru, S. Tabata, and T. Goto
  • Organizer: Abstracts of The 8th International AFAS Joint Symposium between Japan and Korea
  • Place of Presentation: November, Yonago, Japan