| Project/Area Number |
21580369
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Rakuno Gakuen University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SAIDA Kaname 独立行政法人産業技術総合研究所, バイオニクス研究センター, 研究員 (00357055)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 獣医学 / 伴侶動物 / 内科学 / 呼吸循環器 / 腫瘍 / エンドセリン / 循環器 |
|---|
| Research Abstract |
Endothelin-1(ET-1) is a bioactive peptide derived from vascular endothelial cells. Although ET-1 has recently received a lot of attention in human medicine because of its involvement in the pathophysiology of many diseases including heart failure, pulmonary hypertension, renal failure and tumors, no detailed studies on the clinical importance of ET-1 have been performed in veterinary medicine. In this study we investigated the feasibility of using ET-1 as a novel clinical marker to diagnose or assess the prognosis in canine cardiopulmonary and neoplastic disease. Dogs affected with cardiopulmonary disease, mitral valve regurgitation, tricuspid valve regurgitation and pulmonary hypertension, showed a significant increase in serum ET-1 levels compared to healthy dogs. In dogs presenting with hemangiosarcoma, a tumor that originates from vascular endothelial cells, significantly higher serum levels of ET-1 were observed than in dogs with non-neoplastic diseases or with neoplastic diseases other than hemangiosarcoma. Our observations suggest that serum ET-1 levels could be a novel clinical marker for these diseases.
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