Effect of activin E on the prevention and therapy of metabolic syndrome.

• Project/Area Number: 21580370
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Basic veterinary science/Basic zootechnical science
• Research Institution: Kitasato University
• Principal Investigator: HASHIMOTO Osamu 北里大学, 獣医学部, 講師 (90317058)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: インスリン感受性 / エネルギー代謝 / メタボリックシンドローム / 肝臓 / トランスジェニックマウス / 肥満

Research Abstract

To assess the role of activin E, a member of the transforming growth factor-ss superfamily in glucose/energy metabolism, we investigated the transcriptional regulation of activin E in the liver cells and the phenotype of transgenic mice over-expressing activin E. Activin E plays a pathophysiologicalrole in glucose/energy metabolism. The results should help identify the target for the prevention and therapy of metabolic syndrome.

Research Products

• [Journal Article] Identification and characterization of canine growth differentiation factor-9 and its splicing variant (2012)
  • Author(s): Hashimoto, O. Takagi, R., Yanuma, F., Doi, S., Shindo, J., Endo, H., Hasegawa, Y. and Shimasaki, S.
  • Journal Title: Gene Volume: 499 Pages: 266-272
• [Journal Article] Identification and characterization of canine growth differentiation factor-9 and its splicing variant (2012)
  • Author(s): Hashimoto O.
  • Journal Title: Gene Volume: (In press) Issue: 2 Pages: 266-272
  • DOI: 10.1016/j.gene.2012.03.003
  • Peer Reviewed
• [Journal Article] Molecular cloning and expression of canine prolactin gene (2010)
  • Author(s): Hashimoto, O., Yonezawa, T., Sugiyama, Y., Kawaminami, M. and Hasegawa, Y.
  • Journal Title: Exp. Anim. Volume: 59 Pages: 643-646
  • NAID: 130000419260
• [Journal Article] Molecular cloning and expression of canine prolactin gene. (2010)
  • Author(s): Hashimoto O, Yonezawa T, Sugiyama Y, Kawaminami M, Hasegawa Y.
  • Journal Title: Experimental Animals Volume: 59 Pages: 643-646
  • NAID: 130000419260
  • Peer Reviewed
• [Journal Article] The role of activin E in glucose metabolism : Transcriptional regulation of the inhibin/activinss E subunit gene in the liver (2009)
  • Author(s): Hashimoto, O., Sekiyama, K., Matsuo, T. and Hasegawa, Y.
  • Journal Title: Life Sci. Volume: 85 Pages: 534-540
• [Journal Article] Impliction of activin E in glucose metabolism : Transcriptional regulation of the inhibin/activin βE subunit gene in the liver. (2009)
  • Author(s): Hashimoto O., Sekiyama K., Matsuo T., Hasegawa Y.
  • Journal Title: Life Sciences 85 Pages: 534-540
  • Peer Reviewed
• [Journal Article] Abnormalities in Aggression and Anxiety in Transgenic Mice Overexpressing Activin E (2009)
  • Author(s): Sekiyama K.Hashimoto O, Ushiro Y, Adachi C, Kikusui T, Tane mura K, Hasegawa Y.
  • Journal Title: Biochem Biophys Res Commun 385 Pages: 319-323
  • Peer Reviewed
• [Journal Article] Gene expression of the TGF-b family in rat brain infected with Borna disease virus. (2009)
  • Author(s): Nishino Y, Ooishi R, Kurokawa S, Fujino K, Murakami M, Madarame H, Hashimoto O, Sugiyama K, Funaba M.
  • Journal Title: Microbes Infect 11 Pages: 737-743
  • Peer Reviewed
• [Presentation] Roles of the TGF-b family in brown adipocyte differentiation (2011)
  • Author(s): Yoshida, T., Hashimoto, O., Kawada, T., Funaba, M. and Matsui, T.
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-16
• [Presentation] TGF-bファミリーによる褐色脂肪前駆細胞の分化制御 (2011)
  • Author(s): 吉田拓史, 橋本統, 河田照雄, 舟場正幸, 松井徹
  • Organizer: 日本畜産学会第114回大会
  • Place of Presentation: 十和田
  • Year and Date: 2011-08-27
• [Presentation] TGF-βファミリーによる褐色脂肪前駆細胞の分化制御 (2011)
  • Author(s): 吉田拓史
  • Organizer: 日本畜産学会第114回大会
  • Place of Presentation: 北里大学(青森県)
  • Year and Date: 2011-08-27
• [Presentation] Abnormalities in aggression and Anxiety in transgenic mice overexpressing activin E (2010)
  • Author(s): Sekiyama K, Hashimoto O, Hasegawa Y.
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会
  • Place of Presentation: 神戸ポートアイランド(神戸)
  • Year and Date: 2010-12-08
• [Presentation] アクチビンEの糖代謝への関与:肝臓におけるアクチビンE遺伝子の発現調節 (2009)
  • Author(s): 橋本統, 関山一成, 松尾剛, 長谷川喜久
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-02
• [Book] Activin in glucose metabolism (2011)
  • Author(s): Hashimoto, O. and Funaba, M.
  • Publisher: Academic Press
• [Book] Activins and Inhibins(Vitamins and Hormones, Vol.85) (2011)
  • Author(s): Hashimoto O., Funaba M.
  • Publisher: Academic Press