| Project/Area Number |
21580381
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied veterinary science
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKAI Shinji 北里大学, 獣医学部, 教授 (80137900)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | カンピロバクター / アメーバ / 伝播 / 細胞内生存 |
|---|
| Research Abstract |
Campylobacter jejuniis a leading cause of food poisoning all over the world. Contaminated chicken meats are major source of infection in human. Therefore, reduction of C. jejuni-burden in chickens is an important factor for reduction of risk of infection. However, infection route of C. jejuniamong chickens has not been fully understood. Recently, it is suggested that amoeba could be reservoir of C. jejuni. In this study, we tried to identify the genes involving in growth inside of amoeba by using transposon mutagenesis. As results, it was suggested that internalization of C. jejuniinto amoeba depended on flagellar motility but was not necessary for proliferation of bacteria in co-culture with ameba.
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